YRC Public Data Repository - Protein Structure Prediction

Protein:	FABH_ECOLI
Organism:	Escherichia coli
Length:	317 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for FABH_ECOLI.

Description	E-value	Query Range	Subject Range
FABH_NITEU - 3-oxoacyl-[acyl-carrier-protein] synthase 3 OS=Nitrosomonas europaea (strain ATCC 19718 / NBRC 14298... FABH_NITEU - 3-oxoacyl-[acyl-carrier-protein] synthase 3 OS=Nitrosomonas europaea GN=fabH PE=3 SV=1	341.0	[0..1]	[317..1]
FABH_NITEC - 3-oxoacyl-[acyl-carrier-protein] synthase 3 OS=Nitrosomonas eutropha (strain C91) GN=fabH PE=3 SV=1	340.0	[0..1]	[317..3]
FABH_CALS8 - 3-oxoacyl-[acyl-carrier-protein] synthase 3 OS=Caldicellulosiruptor saccharolyticus (strain ATCC 434...	336.0	[0..2]	[317..4]
FABH_CLOAB - 3-oxoacyl-[acyl-carrier-protein] synthase 3 OS=Clostridium acetobutylicum GN=fabH PE=3 SV=1 FABH_CLOAB - 3-oxoacyl-[acyl-carrier-protein] synthase 3 OS=Clostridium acetobutylicum (strain ATCC 824 / DSM 792...	330.0	[0..1]	[317..1]
gi\|78363341, gi\|... - gi\|78485055\|ref\|YP_390980.1\| 3-oxoacyl-(acyl-carrier-protein) synthase III [Thiomicrospira crunogena...	328.0	[0..1]	[317..5]
FABH_NITMU - 3-oxoacyl-[acyl-carrier-protein] synthase 3 OS=Nitrosospira multiformis (strain ATCC 25196 / NCIMB 1...	328.0	[0..2]	[317..3]
gi\|166856536, gi... - gi\|76797521\|ref\|ZP_00779827.1\| Beta-ketoacyl-acyl carrier protein synthase III (FabH) [Thermoanaerob...	327.0	[0..1]	[317..5]
FABH_THETN - 3-oxoacyl-[acyl-carrier-protein] synthase 3 OS=Thermoanaerobacter tengcongensis GN=fabH PE=3 SV=1 FABH_CALS4 - 3-oxoacyl-[acyl-carrier-protein] synthase 3 OS=Caldanaerobacter subterraneus subsp. tengcongensis (s...	326.0	[0..1]	[317..5]
FABH_MARHV - 3-oxoacyl-[acyl-carrier-protein] synthase 3 OS=Marinobacter hydrocarbonoclasticus (strain ATCC 70049...	324.0	[0..2]	[317..3]
gi\|53759435, gi\|... - gi\|91775860\|ref\|YP_545616.1\| 3-oxoacyl-(acyl carrier protein) synthase III [Methylobacillus flagella...	323.0	[0..1]	[317..3]

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Predicted Domain #1

Region A:
Residues: [1-317]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MYTKIIGTGS YLPEQVRTNA DLEKMVDTSD EWIVTRTGIR ERHIAAPNET VSTMGFEAAT  60
   61 RAIEMAGIEK DQIGLIVVAT TSATHAFPSA ACQIQSMLGI KGCPAFDVAA ACAGFTYALS 120
  121 VADQYVKSGA VKYALVVGSD VLARTCDPTD RGTIIIFGDG AGAAVLAASE EPGIISTHLH 180
  181 ADGSYGELLT LPNADRVNPE NSIHLTMAGN EVFKVAVTEL AHIVDETLAA NNLDRSQLDW 240
  241 LVPHQANLRI ISATAKKLGM SMDNVVVTLD RHGNTSAASV PCALDEAVRD GRIKPGQLVL 300
  301 LEAFGGGFTW GSALVRF

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	87.69897
Match:	1hn9A
Description:	Ketoacyl-ACP synthase III (FabH)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
fatty acid synthase activity	3.79121338118181	bayes_pls_golite062009
3-oxoacyl-[acyl-carrier-protein] synthase activity	3.71249191203055	bayes_pls_golite062009
transferase activity, transferring acyl groups other than amino-acyl groups	3.14957464437124	bayes_pls_golite062009
acyltransferase activity	3.06879684191353	bayes_pls_golite062009
transferase activity, transferring acyl groups	2.86538671355391	bayes_pls_golite062009
catalytic activity	2.14505178497871	bayes_pls_golite062009
C-acyltransferase activity	2.11544453922463	bayes_pls_golite062009
acetyl-CoA C-acetyltransferase activity	1.50839304016514	bayes_pls_golite062009
transferase activity	1.45483382098717	bayes_pls_golite062009
C-acetyltransferase activity	1.19264084089277	bayes_pls_golite062009
acetyl-CoA C-acyltransferase activity	0.731877980143765	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: