YRC Public Data Repository - Protein Structure Prediction

Protein:	EUTE_ECOLI
Organism:	Escherichia coli
Length:	467 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for EUTE_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|20372798 - gi\|20372798\|emb\|CAD30313.1\| aldehyde dehydrogenase [Geobacillus stearothermophilus]	556.0	[0..1]	[462..24]
gi\|52785994, gi\|... - gi\|52785994\|ref\|YP_091823.1\| DhaS [Bacillus licheniformis ATCC 14580], gi\|52348496\|gb\|AAU41130.1\| Dh...	554.0	[0..1]	[463..27]
gi\|45523555, gi\|... - gi\|67925207\|ref\|ZP_00518574.1\| Aldehyde dehydrogenase (NAD+) [Crocosphaera watsonii WH 8501], gi\|678...	552.0	[0..1]	[461..20]
gi\|56961829, gi\|... - gi\|56961829\|ref\|YP_173551.1\| aldehyde dehydrogenase [Bacillus clausii KSM-K16], gi\|56908063\|dbj\|BAD6...	551.0	[0..1]	[462..28]
gi\|50756447 - gi\|50756447\|ref\|XP_415171.1\| PREDICTED: similar to Aldehyde dehydrogenase, mitochondrial precursor (...	548.0	[0..1]	[461..43]
gi\|89269880 - gi\|89269880\|emb\|CAJ83424.1\| aldehyde dehydrogenase 2 family (mitochondrial) [Xenopus tropicalis]	548.0	[0..1]	[461..45]
gi\|25284183 - pir\|\|C83717 NADP-dependent aldehyde dehydrogenase dhaS [imported] - Bacillus halodurans (strain C-12... gi\|10173152, gi\|... - gi\|15613102\|ref\|NP_241405.1\| NADP-dependent aldehyde dehydrogenase [Bacillus halodurans C-125], gi\|1...	547.0	[0..1]	[462..28]
gi\|70992355, gi\|... - gi\|70992355\|ref\|XP_751026.1\| aldehyde dehydrogenase AldA [Aspergillus fumigatus Af293], gi\|66848659\|... gi\|159124596 - gi\|159124596\|gb\|EDP49714.1\| aldehyde dehydrogenase AldA, putative [Aspergillus fumigatus A1163]	547.0	[0..1]	[463..85]

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Predicted Domain #1

Region A:
Residues: [1-467]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNQQDIEQVV KAVLLKMQSS DTPSAAVHEM GVFASLDDAV AAAKVAQQGL KSVAMRQLAI  60
   61 AAIREAGEKH ARDLAELAVS ETGMGRVEDK FAKNVAQARG TPGVECLSPQ VLTGDNGLTL 120
  121 IENAPWGVVA SVTPSTNPAA TVINNAISLI AAGNSVIFAP HPAAKKVSQR AITLLNQAIV 180
  181 AAGGPENLLV TVANPDIETA QRLFKFPGIG LLVVTGGEAV VEAARKHTNK RLIAAGAGNP 240
  241 PVVVDETADL ARAAQSIVKG ASFDNNIICA DEKVLIVVDS VADELMRLME GQHAVKLTAE 300
  301 QAQQLQPVLL KNIDERGKGT VSRDWVGRDA GKIAAAIGLK VPQETRLLFV ETTAEHPFAV 360
  361 TELMMPVLPV VRVANVADAI ALAVKLEGGC HHTAAMHSRN IENMNQMANA IDTSIFVKNG 420
  421 PCIAGLGLGG EGWTTMTITT PTGEGVTSAR TFVRLRRCVL VDAFRIV

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	156.0
Match:	1bxsA
Description:	Aldehyde reductase (dehydrogenase), ALDH
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
oxidoreductase activity	3.28348732035689	bayes_pls_golite062009
catalytic activity	3.17848695454129	bayes_pls_golite062009
oxidoreductase activity, acting on the aldehyde or oxo group of donors	1.87933603751128	bayes_pls_golite062009
oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	1.85799041482649	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: