YRC Public Data Repository - Protein Structure Prediction

Protein:	ECFE_ECOLI
Organism:	Escherichia coli
Length:	450 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ECFE_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|213163132 - gi\|213163132\|ref\|ZP_03348842.1\| zinc metallopeptidase [Salmonella enterica subsp. enterica serovar T... ECFE_SALTI, RSEP... - Regulator of sigma E protease OS=Salmonella typhi GN=rseP PE=3 SV=1, Protease ecfE - Salmonella typh... RSEP_SALTI - Regulator of sigma E protease OS=Salmonella typhi GN=rseP PE=3 SV=1 gi\|214000834 - gi\|214000834\|ref\|ZP_03411569.1\| zinc metallopeptidase [Salmonella enterica subsp. enterica serovar T... gi\|29136387, gi\|... - gi\|29140763\|ref\|NP_804105.1\| zinc metallopeptidase [Salmonella enterica subsp. enterica serovar Typh... gi\|213859519 - gi\|213859519\|ref\|ZP_03385223.1\| zinc metallopeptidase [Salmonella enterica subsp. enterica serovar T... gi\|213583003 - gi\|213583003\|ref\|ZP_03364829.1\| zinc metallopeptidase [Salmonella enterica subsp. enterica serovar T... gi\|213425949 - gi\|213425949\|ref\|ZP_03358699.1\| zinc metallopeptidase [Salmonella enterica subsp. enterica serovar T... gi\|16759213 - gi\|16759213\|ref\|NP_454830.1\| zinc metallopeptidase [Salmonella enterica subsp. enterica serovar Typh...	353.0	[0..1]	[450..1]
RSEP_SALT1 - Regulator of sigma-E protease RseP OS=Salmonella typhimurium (strain 14028s / SGSC 2262) GN=rsep PE=... gi\|204926960, gi... - gi\|204926960\|ref\|ZP_03218162.1\| RIP metalloprotease RseP [Salmonella enterica subsp. enterica serova... RSEP_SALTY - Regulator of sigma E protease OS=Salmonella typhimurium GN=rseP PE=3 SV=1 gi\|200388259, gi... - gi\|200388259\|ref\|ZP_03214871.1\| RIP metalloprotease RseP [Salmonella enterica subsp. enterica serova... gi\|205271341, gi... - gi\|205351560\|ref\|YP_002225361.1\| zinc metallopeptidase RseP [Salmonella enterica subsp. enterica ser... gi\|197249547, gi... - gi\|197249547\|ref\|YP_002145228.1\| RIP metalloprotease RseP [Salmonella enterica subsp. enterica serov... gi\|56126753, gi\|... - gi\|56412496\|ref\|YP_149571.1\| zinc metallopeptidase RseP [Salmonella enterica subsp. enterica serovar... gi\|194735257, gi... - gi\|194735257\|ref\|YP_002113246.1\| RIP metalloprotease RseP [Salmonella enterica subsp. enterica serov... gi\|197361431, gi... - gi\|197361431\|ref\|YP_002141067.1\| zinc metallopeptidase RseP [Salmonella enterica subsp. enterica ser... ECFE_SALTY, RSEP... - Regulator of sigma E protease OS=Salmonella typhimurium GN=rseP PE=3 SV=1, Protease ecfE - Salmonell... gi\|197243939, gi... - gi\|197265684\|ref\|ZP_03165758.1\| RIP metalloprotease RseP [Salmonella enterica subsp. enterica serova... gi\|194444218, gi... - gi\|194444218\|ref\|YP_002039463.1\| RIP metalloprotease RseP [Salmonella enterica subsp. enterica serov... gi\|168823252, gi... - gi\|205340483\|gb\|EDZ27247.1\| RIP metalloprotease RseP [Salmonella enterica subsp. enterica serovar We... gi\|194469383, gi... - gi\|194469383\|ref\|ZP_03075367.1\| RIP metalloprotease RseP [Salmonella enterica subsp. enterica serova... gi\|194407707, gi... - gi\|194449403\|ref\|YP_002044213.1\| zinc metallopeptidase RseP [Salmonella enterica subsp. enterica ser... gi\|168244990, gi... - gi\|205336216\|gb\|EDZ22980.1\| RIP metalloprotease RseP [Salmonella enterica subsp. enterica serovar He... gi\|197291779, gi... - gi\|197291779\|gb\|EDY31129.1\| RIP metalloprotease RseP [Salmonella enterica subsp. enterica serovar Sc... RSEP_SALTY - Regulator of sigma E protease OS=Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) GN=rse... gi\|168464213, gi... - gi\|195632931\|gb\|EDX51385.1\| RIP metalloprotease RseP [Salmonella enterica subsp. enterica serovar Ne... gi\|205347437, gi... - gi\|205347437\|gb\|EDZ34068.1\| RIP metalloprotease RseP [Salmonella enterica subsp. enterica serovar Ha... gi\|205322186, gi... - gi\|205322186\|gb\|EDZ10025.1\| RIP metalloprotease RseP [Salmonella enterica subsp. enterica serovar Sa... gi\|161361959, gi... - gi\|161612595\|ref\|YP_001586560.1\| zinc metallopeptidase [Salmonella enterica subsp. enterica serovar ... gi\|168230531, gi... - gi\|205335120\|gb\|EDZ21884.1\| RIP metalloprotease RseP [Salmonella enterica subsp. enterica serovar Ke... gi\|167990109, gi... - gi\|205331445\|gb\|EDZ18209.1\| RIP metalloprotease RseP [Salmonella enterica subsp. enterica serovar 4,...	352.0	[0..1]	[450..1]
gi\|224582071, gi... - gi\|224582071\|ref\|YP_002635869.1\| hypothetical protein SPC_0239 [Salmonella enterica subsp. enterica ... gi\|62178793, gi\|... - gi\|62178793\|ref\|YP_215210.1\| zinc metallopeptidase [Salmonella enterica subsp. enterica serovar Chol...	352.0	[0..1]	[450..1]
gi\|30039975, gi\|... - gi\|30061733\|ref\|NP_835904.1\| zinc metallopeptidase [Shigella flexneri 2a str. 2457T], gi\|30039975\|gb... gi\|56479619, gi\|... - gi\|56479619\|ref\|NP_706121.2\| zinc metallopeptidase [Shigella flexneri 2a str. 301], gi\|56383170\|gb\|A...	349.0	[0..1]	[450..1]
gi\|218363886, gi... - gi\|218557117\|ref\|YP_002390030.1\| zinc metallopeptidase RseP [Escherichia coli S88], gi\|218363886\|emb... gi\|191172791, gi... - gi\|75240235\|ref\|ZP_00724182.1\| COG0750: Predicted membrane-associated Zn-dependent proteases 1 [Esch... gi\|218425615, gi... - gi\|218688051\|ref\|YP_002396263.1\| zinc metallopeptidase RseP [Escherichia coli ED1a], gi\|218425615\|em... gi\|227838049, gi... - gi\|227884911\|ref\|ZP_04002716.1\| RIP metalloprotease RseP [Escherichia coli 83972], gi\|227838049\|gb\|E... gi\|110640395, gi... - gi\|110640395\|ref\|YP_668123.1\| zinc metallopeptidase RseP [Escherichia coli 536], gi\|110341987\|gb\|ABG... gi\|117622461, gi... - gi\|117622461\|ref\|YP_851374.1\| zinc metallopeptidase [Escherichia coli APEC O1], gi\|115511585\|gb\|ABI9...	349.0	[0..1]	[450..1]
gi\|218552757, gi... - gi\|218552757\|ref\|YP_002385670.1\| zinc metallopeptidase RseP [Escherichia coli IAI1], gi\|218359525\|em... gi\|75194386, gi\|... - gi\|75194386\|ref\|ZP_00704456.1\| COG0750: Predicted membrane-associated Zn-dependent proteases 1 [Esch...	348.0	[0..1]	[450..1]
gi\|26246122, gi\|... - gi\|26246122\|ref\|NP_752161.1\| zinc metallopeptidase [Escherichia coli CFT073], gi\|26106519\|gb\|AAN7870... gi\|226902247, gi... - gi\|237704335\|ref\|ZP_04534816.1\| zinc metallopeptidase [Escherichia sp. 3_2_53FAA], gi\|226902247\|gb\|E... gi\|91209246, gi\|... - gi\|91209246\|ref\|YP_539232.1\| zinc metallopeptidase [Escherichia coli UTI89], gi\|91070820\|gb\|ABE05701...	348.0	[0..1]	[450..16]
gi\|157156244, gi... - gi\|75189271\|ref\|ZP_00702538.1\| COG0750: Predicted membrane-associated Zn-dependent proteases 1 [Esch...	348.0	[0..1]	[450..1]
gi\|150841341, gi... - gi\|75434009\|ref\|ZP_00733177.1\| membrane-associated Zn-dependent proteases 1 [Actinobacillus succinog...	348.0	[0..2]	[450..1]
gi\|92112703, gi\|... - gi\|92112703\|ref\|YP_572631.1\| peptidase M50, putative membrane-associated zinc metallopeptidase [Chro...	347.0	[0..2]	[450..1]

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Predicted Domain #1

Region A:
Residues: [1-382]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLSFLWDLAS FIVALGVLIT VHEFGHFWVA RRCGVRVERF SIGFGKALWR RTDKLGTEYV  60
   61 IALIPLGGYV KMLDERAEPV VPELRHHAFN NKSVGQRAAI IAAGPVANFI FAIFAYWLVF 120
  121 IIGVPGVRPV VGEIAANSIA AEAQIAPGTE LKAVDGIETP DWDAVRLQLV DKIGDESTTI 180
  181 TVAPFGSDQR RDVKLDLRHW AFEPDKEDPV SSLGIRPRGP QIEPVLENVQ PNSAASKAGL 240
  241 QAGDRIVKVD GQPLTQWVTF VMLVRDNPGK SLALEIERQG SPLSLTLIPE SKPGNGKAIG 300
  301 FVGIEPKVIP LPDEYKVVRQ YGPFNAIVEA TDKTWQLMKL TVSMLGKLIT GDVKLNNLSG 360
  361 PISIAKGAGM TAELGVVYYL PF

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	26.09691
Match:	1ky9A
Description:	Protease Do (DegP, HtrA), C-terminal domains; Protease Do (DegP, HtrA), catalytic domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
peptidase activity	4.77028935267086	bayes_pls_golite062009
peptidase activity, acting on L-amino acid peptides	4.38506541212306	bayes_pls_golite062009
endopeptidase activity	3.78841204092284	bayes_pls_golite062009
serine hydrolase activity	3.40985043278892	bayes_pls_golite062009
serine-type peptidase activity	3.40724860044542	bayes_pls_golite062009
hydrolase activity	3.15103157395079	bayes_pls_golite062009
serine-type endopeptidase activity	3.13486560415684	bayes_pls_golite062009
catalytic activity	1.40927913545237	bayes_pls_golite062009
receptor activity	0.165051160476865	bayes_pls_golite062009
protein domain specific binding	0.0675941009743699	bayes_pls_golite062009
protein binding	0.0013332686405948	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [383-450]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LALISVNLGI INLFPLPVLD GGHLLFLAIE KIKGGPVSER VQDFCYRIGS ILLVLLMGLA  60
   61 LFNDFSRL

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: