YRC Public Data Repository - Protein Structure Prediction

Protein:	DHG_ECOLI
Organism:	Escherichia coli
Length:	796 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for DHG_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|192931080, gi... - gi\|75258883\|ref\|ZP_00730273.1\| COG4993: Glucose dehydrogenase [Escherichia coli E22], gi\|193063172\|r... gi\|75210451, gi\|... - gi\|75210451\|ref\|ZP_00710602.1\| COG4993: Glucose dehydrogenase [Escherichia coli B171], gi\|194428297\|... gi\|157065272, gi... - gi\|75194339\|ref\|ZP_00704409.1\| COG4993: Glucose dehydrogenase [Escherichia coli HS], gi\|157159592\|re...	672.0	[0..1]	[796..1]
gi\|91070766, gi\|... - gi\|91209192\|ref\|YP_539178.1\| glucose dehydrogenase [Escherichia coli UTI89], gi\|91070766\|gb\|ABE05647... gi\|226902192, gi... - gi\|237704280\|ref\|ZP_04534761.1\| glucose dehydrogenase [Escherichia sp. 3_2_53FAA], gi\|226902192\|gb\|E...	671.0	[0..1]	[796..7]
gi\|26246064, gi\|... - gi\|26246064\|ref\|NP_752103.1\| glucose dehydrogenase [Escherichia coli CFT073], gi\|26106461\|gb\|AAN7864...	671.0	[0..1]	[796..7]
gi\|110613733, gi... - gi\|110804185\|ref\|YP_687705.1\| glucose dehydrogenase [Shigella flexneri 5 str. 8401], gi\|110613733\|gb...	671.0	[0..1]	[796..7]
gi\|208739984, gi... - gi\|208819861\|ref\|ZP_03260181.1\| quinoprotein glucose dehydrogenase [Escherichia coli O157:H7 str. EC... gi\|208811973, gi... - gi\|208811973\|ref\|ZP_03253302.1\| quinoprotein glucose dehydrogenase [Escherichia coli O157:H7 str. EC... gi\|217326574, gi... - gi\|217326574\|ref\|ZP_03442658.1\| quinoprotein glucose dehydrogenase [Escherichia coli O157:H7 str. TW... gi\|209162240, gi... - gi\|209400840\|ref\|YP_002268732.1\| quinoprotein glucose dehydrogenase [Escherichia coli O157:H7 str. E... gi\|189360664, gi... - gi\|189360664\|gb\|EDU79083.1\| quinoprotein glucose dehydrogenase [Escherichia coli O157:H7 str. EC4486... gi\|83585443, gi\|... - gi\|83585443\|ref\|ZP_00924088.1\| COG4993: Glucose dehydrogenase [Escherichia coli 101-1], gi\|194439115... gi\|168764733, gi... - gi\|189365333\|gb\|EDU83749.1\| quinoprotein glucose dehydrogenase [Escherichia coli O157:H7 str. EC4501... gi\|157155401, gi... - gi\|75189223\|ref\|ZP_00702490.1\| COG4993: Glucose dehydrogenase [Escherichia coli E24377A], gi\|1571554... gi\|189000471, gi... - gi\|189000471\|gb\|EDU69457.1\| quinoprotein glucose dehydrogenase [Escherichia coli O157:H7 str. EC4076... gi\|191166356, gi... - gi\|75230511\|ref\|ZP_00716992.1\| COG4993: Glucose dehydrogenase [Escherichia coli B7A], gi\|191166356\|r... gi\|168776834, gi... - gi\|187767842\|gb\|EDU31686.1\| quinoprotein glucose dehydrogenase [Escherichia coli O157:H7 str. EC4196... gi\|188491790, gi... - gi\|75511999\|ref\|ZP_00734594.1\| COG4993: Glucose dehydrogenase [Escherichia coli 53638], gi\|188491790... gi\|169756450, gi... - gi\|170021522\|ref\|YP_001726476.1\| PQQ-dependent dehydrogenase glucose/quinate/shikimate family protei... gi\|189371066, gi... - gi\|189371066\|gb\|EDU89482.1\| quinoprotein glucose dehydrogenase [Escherichia coli O157:H7 str. EC869]... gi\|208728160, gi... - gi\|208808359\|ref\|ZP_03250696.1\| quinoprotein glucose dehydrogenase [Escherichia coli O157:H7 str. EC... gi\|195938194 - gi\|195938194\|ref\|ZP_03083576.1\| PQQ-dependent dehydrogenase glucose/quinate/shikimate family protein... gi\|15799808, gi\|... - gi\|15799808\|ref\|NP_285820.1\| glucose dehydrogenase [Escherichia coli O157:H7 EDL933], gi\|12512839\|gb... gi\|15829382, gi\|... - gi\|15829382\|ref\|NP_308155.1\| glucose dehydrogenase [Escherichia coli O157:H7 str. Sakai], gi\|1335958... gi\|242375957, gi... - gi\|251783684\|ref\|YP_002997988.1\| hypothetical protein B21_00122 [Escherichia coli BL21], gi\|24237595... gi\|124499113, gi... - gi\|124530586\|ref\|ZP_01701189.1\| Quinoprotein glucose dehydrogenase [Escherichia coli B], gi\|12449911... gi\|254287047, gi... - gi\|254287047\|ref\|YP_003052795.1\| glucose dehydrogenase [Escherichia coli BL21(DE3)], gi\|253976354\|gb... gi\|253972145, gi... - gi\|254160244\|ref\|YP_003043352.1\| glucose dehydrogenase [Escherichia coli B str. REL606], gi\|25397214... gi\|254791259, gi... - gi\|254791259\|ref\|YP_003076096.1\| glucose dehydrogenase [Escherichia coli O157:H7 str. TW14359], gi\|2... gi\|15829382, gi\|... - gi\|15829382\|ref\|NP_308155.1\| glucose dehydrogenase [Escherichia coli O157:H7], gi\|13359584\|dbj\|BAB33... gi\|209746218, gi... - pir\|\|H85495 glucose dehydrogenase [imported] - Escherichia coli (strain O157:H7, substrain EDL933),... gi\|168755735, gi... - gi\|189357082\|gb\|EDU75501.1\| quinoprotein glucose dehydrogenase [Escherichia coli O157:H7 str. EC4401...	670.0	[0..1]	[796..1]
gi\|75240284, gi\|... - gi\|75240284\|ref\|ZP_00724231.1\| COG4993: Glucose dehydrogenase [Escherichia coli F11], gi\|191172806\|r... gi\|110341935, gi... - gi\|110640343\|ref\|YP_668071.1\| glucose dehydrogenase [Escherichia coli 536], gi\|110341935\|gb\|ABG68172... gi\|218688002, gi... - gi\|218688002\|ref\|YP_002396214.1\| glucose dehydrogenase [Escherichia coli ED1a], gi\|218425566\|emb\|CAR... gi\|227884965, gi... - gi\|227884965\|ref\|ZP_04002770.1\| glucose dehydrogenase [Escherichia coli 83972], gi\|227838103\|gb\|EEJ4...	670.0	[0..1]	[796..1]
gi\|218557067, gi... - gi\|218557067\|ref\|YP_002389980.1\| glucose dehydrogenase [Escherichia coli S88], gi\|218363836\|emb\|CAR0... gi\|117622411, gi... - gi\|117622411\|ref\|YP_851324.1\| glucose dehydrogenase [Escherichia coli APEC O1], gi\|115511535\|gb\|ABI9...	670.0	[0..1]	[796..1]
gi\|81244138, gi\|... - gi\|82542727\|ref\|YP_406674.1\| glucose dehydrogenase [Shigella boydii Sb227], gi\|81244138\|gb\|ABB64846....	669.0	[0..1]	[796..1]
gi\|30039931, gi\|... - gi\|30061689\|ref\|NP_835860.1\| glucose dehydrogenase [Shigella flexneri 2a str. 2457T], gi\|30039931\|gb...	669.0	[0..1]	[796..1]
gi\|53689169 - gi\|53689169\|gb\|AAQ93677.2\| glucose dehydrogenase [Enterobacter asburiae]	669.0	[0..1]	[796..1]

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Predicted Domain #1

Region A:
Residues: [1-116]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAINNTGSRR LLVTLTALFA ALCGLYLLIG GGWLVAIGGS WYYPIAGLVM LGVAWMLWRS  60
   61 KRAALWLYAA LLLGTMIWGV WEVGFDFWAL TPRSDILVFF GIWLILPFVW RRLVIP

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2

Region A:
Residues: [117-796]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ASGAVAALVV ALLISGGILT WAGFNDPQEI NGTLSADATP AEAISPVADQ DWPAYGRNQE  60
   61 GQRFSPLKQI NADNVHNLKE AWVFRTGDVK QPNDPGEITN EVTPIKVGDT LYLCTAHQRL 120
  121 FALDAASGKE KWHYDPELKT NESFQHVTCR GVSYHEAKAE TASPEVMADC PRRIILPVND 180
  181 GRLIAINAEN GKLCETFANK GVLNLQSNMP DTKPGLYEPT SPPIITDKTI VMAGSVTDNF 240
  241 STRETSGVIR GFDVNTGELL WAFDPGAKDP NAIPSDEHTF TFNSPNSWAP AAYDAKLDLV 300
  301 YLPMGVTTPD IWGGNRTPEQ ERYASSILAL NATTGKLAWS YQTVHHDLWD MDLPAQPTLA 360
  361 DITVNGQKVP VIYAPAKTGN IFVLDRRNGE LVVPAPEKPV PQGAAKGDYV TPTQPFSELS 420
  421 FRPTKDLSGA DMWGATMFDQ LVCRVMFHQM RYEGIFTPPS EQGTLVFPGN LGMFEWGGIS 480
  481 VDPNREVAIA NPMALPFVSK LIPRGPGNPM EQPKDAKGTG TESGIQPQYG VPYGVTLNPF 540
  541 LSPFGLPCKQ PAWGYISALD LKTNEVVWKK RIGTPQDSMP FPMPVPVPFN MGMPMLGGPI 600
  601 STAGNVLFIA ATADNYLRAY NMSNGEKLWQ GRLPAGGQAT PMTYEVNGKQ YVVISAGGHG 660
  661 SFGTKMGDYI VAYALPDDVK

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	88.69897
Match:	1kv9A
Description:	Quinoprotein alcohol dehydrogenase, C-terminal domain; Quinoprotein alcohol dehydrogenase, N-terminal domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
quinate dehydrogenase (pyrroloquinoline-quinone) activity	4.20936217598692	bayes_pls_golite062009
catalytic activity	1.77011790035856	bayes_pls_golite062009
oxidoreductase activity, acting on CH-OH group of donors	1.3680975186283	bayes_pls_golite062009
oxidoreductase activity	1.34661652476793	bayes_pls_golite062009
alcohol dehydrogenase (acceptor) activity	0.913259651893531	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: