YRC Public Data Repository - Protein Structure Prediction

Protein:	DAPB_ECOLI
Organism:	Escherichia coli
Length:	273 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for DAPB_ECOLI.

Description	E-value	Query Range	Subject Range
DAPB_HAES1 - 4-hydroxy-tetrahydrodipicolinate reductase OS=Haemophilus somnus (strain 129Pt) GN=dapB PE=3 SV=1	287.0	[0..5]	[273..2]
DAPB_SHEAM - 4-hydroxy-tetrahydrodipicolinate reductase OS=Shewanella amazonensis (strain ATCC BAA-1098 / SB2B) G...	284.0	[0..1]	[271..1]
DAPB_HISS2 - 4-hydroxy-tetrahydrodipicolinate reductase OS=Histophilus somni (strain 2336) GN=dapB PE=3 SV=1	284.0	[0..5]	[273..2]
gi\|121547078, gi... - gi\|121591073\|ref\|ZP_01678385.1\| dihydrodipicolinate reductase [Vibrio cholerae 2740-80], gi\|12154707... DAPB_VIBC3 - 4-hydroxy-tetrahydrodipicolinate reductase OS=Vibrio cholerae serotype O1 (strain ATCC 39541 / Class... gi\|153802032, gi... - gi\|153802032\|ref\|ZP_01956618.1\| dihydrodipicolinate reductase [Vibrio cholerae MZO-3], gi\|124122442\|... gi\|153225219, gi... - gi\|153225219\|ref\|ZP_01954720.1\| dihydrodipicolinate reductase [Vibrio cholerae MAK 757], gi\|12411734... tr\|A0A085PQM1\|A0... - 4-hydroxy-tetrahydrodipicolinate reductase OS=Vibrio cholerae GN=dapB PE=3 SV=1, 4-hydroxy-tetrahydr... gi\|121630159, gi... - gi\|75816493\|ref\|ZP_00746962.1\| COG0289: Dihydrodipicolinate reductase [Vibrio cholerae V52], gi\|1217... gi\|254226143, gi... - gi\|75817965\|ref\|ZP_00748208.1\| COG0289: Dihydrodipicolinate reductase [Vibrio cholerae V51], gi\|2542... gi\|126509470, gi... - gi\|153819992\|ref\|ZP_01972659.1\| dihydrodipicolinate reductase [Vibrio cholerae NCTC 8457], gi\|126509... gi\|153828832, gi... - gi\|153828832\|ref\|ZP_01981499.1\| dihydrodipicolinate reductase [Vibrio cholerae 623-39], gi\|148875708... DAPB_VIBCM - 4-hydroxy-tetrahydrodipicolinate reductase OS=Vibrio cholerae serotype O1 (strain M66-2) GN=dapB PE=...	282.0	[0..6]	[273..2]
DAPB_PELCD - 4-hydroxy-tetrahydrodipicolinate reductase OS=Pelobacter carbinolicus (strain DSM 2380 / Gra Bd 1) G...	282.0	[0..6]	[271..2]
gi\|153823332, gi... - gi\|153823332\|ref\|ZP_01975999.1\| dihydrodipicolinate reductase [Vibrio cholerae B33], gi\|126519139\|gb... DAPB_VIBCH - 4-hydroxy-tetrahydrodipicolinate reductase OS=Vibrio cholerae serotype O1 (strain ATCC 39315 / El To... DAPB_VIBCH - Dihydrodipicolinate reductase OS=Vibrio cholerae GN=dapB PE=3 SV=1 gi\|254849514, gi... - gi\|75828900\|ref\|ZP_00758230.1\| COG0289: Dihydrodipicolinate reductase [Vibrio cholerae MO10], gi\|254...	282.0	[0..6]	[273..2]
DAPB_HAHCH - 4-hydroxy-tetrahydrodipicolinate reductase OS=Hahella chejuensis (strain KCTC 2396) GN=dapB PE=3 SV=...	282.0	[0..7]	[271..3]
DAPB_SHEDO - 4-hydroxy-tetrahydrodipicolinate reductase OS=Shewanella denitrificans (strain OS217 / ATCC BAA-1090...	282.0	[0..1]	[271..1]
DAPB_PHOLL - 4-hydroxy-tetrahydrodipicolinate reductase OS=Photorhabdus luminescens subsp. laumondii (strain DSM ... DAPB_PHOLL - Dihydrodipicolinate reductase OS=Photorhabdus luminescens subsp. laumondii GN=dapB PE=3 SV=1	281.0	[0..1]	[271..1]
gi\|53729186 - gi\|53729186\|ref\|ZP_00134031.2\| COG0289: Dihydrodipicolinate reductase [Actinobacillus pleuropneumoni...	281.0	[0..5]	[273..2]

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Predicted Domain #1

Region A:
Residues: [1-273]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MHDANIRVAI AGAGGRMGRQ LIQAALALEG VQLGAALERE GSSLLGSDAG ELAGAGKTGV  60
   61 TVQSSLDAVK DDFDVFIDFT RPEGTLNHLA FCRQHGKGMV IGTTGFDEAG KQAIRDAAAD 120
  121 IAIVFAANFS VGVNVMLKLL EKAAKVMGDY TDIEIIEAHH RHKVDAPSGT ALAMGEAIAH 180
  181 ALDKDLKDCA VYSREGHTGE RVPGTIGFAT VRAGDIVGEH TAMFADIGER LEITHKASSR 240
  241 MTFANGAVRS ALWLSGKESG LFDMRDVLDL NNL

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	72.69897
Match:	1arzA
Description:	Dihydrodipicolinate reductase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
oxidoreductase activity	2.60548927745815	bayes_pls_golite062009
catalytic activity	2.54843319568228	bayes_pls_golite062009
oxidoreductase activity, acting on the aldehyde or oxo group of donors	1.54909195188343	bayes_pls_golite062009
oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	0.841370849960815	bayes_pls_golite062009
saccharopine dehydrogenase activity	0.495113665163626	bayes_pls_golite062009
N-acetyl-gamma-glutamyl-phosphate reductase activity	0.0651785123513661	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: