YRC Public Data Repository - Protein Structure Prediction

Protein:	DAPA_ECOLI
Organism:	Escherichia coli
Length:	292 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for DAPA_ECOLI.

Description	E-value	Query Range	Subject Range
DAPA_BARBK - 4-hydroxy-tetrahydrodipicolinate synthase OS=Bartonella bacilliformis (strain ATCC 35685 / KC583) GN...	370.0	[0..1]	[292..1]
DAPA_GEOUR - 4-hydroxy-tetrahydrodipicolinate synthase OS=Geobacter uraniireducens (strain Rf4) GN=dapA PE=3 SV=1	360.0	[0..1]	[292..1]
gi\|83647587, gi\|... - gi\|83647587\|ref\|YP_436022.1\| dihydrodipicolinate synthase [Hahella chejuensis KCTC 2396], gi\|8363563...	356.0	[0..1]	[292..1]
DAPA_GEOMG - 4-hydroxy-tetrahydrodipicolinate synthase OS=Geobacter metallireducens (strain GS-15 / ATCC 53774 / ...	355.0	[0..1]	[292..1]
DAPA_SYNFM - 4-hydroxy-tetrahydrodipicolinate synthase OS=Syntrophobacter fumaroxidans (strain DSM 10017 / MPOB) ...	355.0	[0..1]	[292..1]
gi\|241906440, gi... - gi\|241906440\|ref\|ZP_04791022.1\| dihydrodipicolinate synthase [Desulfovibrio vulgaris RCH1], gi\|24188... DAPA_DESVV - 4-hydroxy-tetrahydrodipicolinate synthase OS=Desulfovibrio vulgaris subsp. vulgaris (strain DP4) GN=... DAPA_DESVH - 4-hydroxy-tetrahydrodipicolinate synthase OS=Desulfovibrio vulgaris (strain Hildenborough / ATCC 295...	354.0	[0..2]	[292..3]
DAPA_GEOSL - Dihydrodipicolinate synthase OS=Geobacter sulfurreducens GN=dapA PE=3 SV=1 DAPA_GEOSL - 4-hydroxy-tetrahydrodipicolinate synthase OS=Geobacter sulfurreducens (strain ATCC 51573 / DSM 12127...	354.0	[0..1]	[292..1]
DAPA_AQUAE - Dihydrodipicolinate synthase OS=Aquifex aeolicus GN=dapA PE=1 SV=1 DAPA_AQUAE - 4-hydroxy-tetrahydrodipicolinate synthase OS=Aquifex aeolicus (strain VF5) GN=dapA PE=1 SV=1	354.0	[0..1]	[291..1]
gi\|114316033, gi... - gi\|114327859\|ref\|YP_745016.1\| dihydrodipicolinate synthase [Granulibacter bethesdensis CGDNIH1], gi\|...	353.0	[0..1]	[292..34]
gi\|91202476 - gi\|91202476\|emb\|CAJ72115.1\| strongly similar to dihydropicolinate synthase (DHDPS) [Candidatus Kuene...	353.0	[0..1]	[292..1]

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Predicted Domain #1

Region A:
Residues: [1-292]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MFTGSIVAIV TPMDEKGNVC RASLKKLIDY HVASGTSAIV SVGTTGESAT LNHDEHADVV  60
   61 MMTLDLADGR IPVIAGTGAN ATAEAISLTQ RFNDSGIVGC LTVTPYYNRP SQEGLYQHFK 120
  121 AIAEHTDLPQ ILYNVPSRTG CDLLPETVGR LAKVKNIIGI KEATGNLTRV NQIKELVSDD 180
  181 FVLLSGDDAS ALDFMQLGGH GVISVTANVA ARDMAQMCKL AAEGHFAEAR VINQRLMPLH 240
  241 NKLFVEPNPI PVKWACKELG LVATDTLRLP MTPITDSGRE TVRAALKHAG LL

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	96.0
Match:	1dhpA
Description:	Dihydrodipicolinate synthase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
catalytic activity	1.76981344014746	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: