YRC Public Data Repository - Protein Structure Prediction

Protein:	CYNT_ECOLI
Organism:	Escherichia coli
Length:	219 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CYNT_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|75211131, gi\|... - gi\|75211131\|ref\|ZP_00711238.1\| COG0288: Carbonic anhydrase [Escherichia coli B171], gi\|194427575\|ref...	261.0	[0..1]	[219..1]
gi\|25291486 - pir\|\|H90677 carbonic anhydrase [imported] - Escherichia coli (strain O157:H7, substrain RIMD 0509952... gi\|15829646, gi\|... - gi\|15829646\|ref\|NP_308419.1\| carbonic anhydrase [Escherichia coli O157:H7], gi\|13359849\|dbj\|BAB33815... gi\|15829646, gi\|... - gi\|15829646\|ref\|NP_308419.1\| carbonic anhydrase [Escherichia coli O157:H7 str. Sakai], gi\|13359849\|d...	257.0	[0..1]	[219..1]
gi\|194438201, gi... - gi\|83586375\|ref\|ZP_00925010.1\| COG0288: Carbonic anhydrase [Escherichia coli 101-1], gi\|194438201\|re...	256.0	[0..1]	[219..1]
gi\|78063663, gi\|... - gi\|78063663\|ref\|YP_373571.1\| carbonate dehydratase [Burkholderia sp. 383], gi\|77971548\|gb\|ABB12927.1...	252.0	[0..1]	[219..1]
gi\|145642 - gi\|145642\|gb\|AAA23625.1\| cyanate permease [Escherichia coli]	252.0	[0..1]	[219..1]
gi\|67104783, gi\|... - gi\|67661552\|ref\|ZP_00458844.1\| Carbonate dehydratase [Burkholderia cenocepacia HI2424], gi\|67104783\|... gi\|118712611, gi... - gi\|170736509\|ref\|YP_001777769.1\| carbonate dehydratase [Burkholderia cenocepacia MC0-3], gi\|16981869... gi\|67655060, gi\|... - gi\|67655060\|ref\|ZP_00452447.1\| Carbonate dehydratase [Burkholderia cenocepacia AU 1054], gi\|67097198...	251.0	[0..1]	[219..1]
gi\|67755780, gi\|... - gi\|67755780\|ref\|ZP_00494670.1\| COG0288: Carbonic anhydrase [Burkholderia pseudomallei Pasteur], gi\|1... gi\|67684700, gi\|... - gi\|90293310\|ref\|ZP_01212912.1\| hypothetical protein Bpse17_02001959 [Burkholderia pseudomallei 1710a...	250.0	[0..1]	[219..5]
gi\|83634860, gi\|... - gi\|83646817\|ref\|YP_435252.1\| carbonic anhydrase [Hahella chejuensis KCTC 2396], gi\|83634860\|gb\|ABC30...	250.0	[0..1]	[218..1]
gi\|52210971, gi\|... - gi\|53720557\|ref\|YP_109543.1\| carbonic anhydrase [Burkholderia pseudomallei K96243], gi\|52210971\|emb\|... gi\|161373467 - gi\|161373467\|ref\|ZP_02113022.1\| carbonic anhydrase [Burkholderia pseudomallei 1710a] gi\|254190933, gi... - gi\|254190933\|ref\|ZP_04897439.1\| carbonic anhydrase [Burkholderia pseudomallei Pasteur 52237], gi\|194...	250.0	[0..1]	[219..1]
gi\|82531085 - gi\|82531085\|ref\|ZP_00890307.1\| COG0288: Carbonic anhydrase [Burkholderia pseudomallei 1106a] gi\|82534172, gi\|... - gi\|90661807\|ref\|ZP_01249645.1\| hypothetical protein Bpse110_02006371 [Burkholderia pseudomallei 1106... gi\|83680103, gi\|... - gi\|83680103\|ref\|ZP_00941811.1\| COG0288: Carbonic anhydrase [Burkholderia pseudomallei 406e], gi\|2542... gi\|67673364, gi\|... - gi\|99912810\|ref\|ZP_01319508.1\| hypothetical protein Bpse1_03001075 [Burkholderia pseudomallei 1655],...	250.0	[0..1]	[219..5]

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Predicted Domain #1

Region A:
Residues: [1-219]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKEIIDGFLK FQREAFPKRE ALFKQLATQQ SPRTLFISCS DSRLVPELVT QREPGDLFVI  60
   61 RNAGNIVPSY GPEPGGVSAS VEYAVAALRV SDIVICGHSN CGAMTAIASC QCMDHMPAVS 120
  121 HWLRYADSAR VVNEARPHSD LPSKAAAMVR ENVIAQLANL QTHPSVRLAL EEGRIALHGW 180
  181 VYDIESGSIA AFDGATRQFV PLAANPRVCA IPLRQPTAA

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	63.522879
Match:	1i6oA
Description:	beta-carbonic anhydrase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
carbonate dehydratase activity	2.96380803089124	bayes_pls_golite062009
catalytic activity	1.85658156053797	bayes_pls_golite062009
carbon-oxygen lyase activity	1.691366175135	bayes_pls_golite062009
hydro-lyase activity	1.65497918079842	bayes_pls_golite062009
lyase activity	1.62374861994341	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: