YRC Public Data Repository - Protein Structure Prediction

Protein:	CILA_ECOLI
Organism:	Escherichia coli
Length:	510 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CILA_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|110614158, gi... - gi\|110804610\|ref\|YP_688130.1\| citrate lyase alpha chain [Shigella flexneri 5 str. 8401], gi\|11061415...	440.0	[0..1]	[510..15]
gi\|30062072, gi\|... - gi\|30062072\|ref\|NP_836243.1\| citrate lyase alpha chain [Shigella flexneri 2a str. 2457T], gi\|3004031... gi\|24111959, gi\|... - gi\|24111959\|ref\|NP_706469.1\| citrate lyase alpha chain [Shigella flexneri 2a str. 301], gi\|24050769\|...	440.0	[0..1]	[510..1]
gi\|237707412, gi... - gi\|237707412\|ref\|ZP_04537893.1\| citrate lyase subunit alpha [Escherichia sp. 3_2_53FAA], gi\|22689862... gi\|117622835, gi... - gi\|117622835\|ref\|YP_851748.1\| citrate lyase alpha chain [Escherichia coli APEC O1], gi\|115511959\|gb\|...	438.0	[0..1]	[510..15]
gi\|193069120, gi... - gi\|75236597\|ref\|ZP_00720685.1\| COG3051: Citrate lyase, alpha subunit [Escherichia coli E110019], gi\|...	438.0	[0..1]	[510..1]
gi\|218694056, gi... - gi\|218694056\|ref\|YP_002401723.1\| citrate lyase, citrate-ACP transferase (alpha) subunit [Escherichia... gi\|251784118, gi... - gi\|251784118\|ref\|YP_002998422.1\| hypothetical protein B21_00572 [Escherichia coli BL21], gi\|24237639... gi\|209917874, gi... - gi\|209917874\|ref\|YP_002291958.1\| citrate lyase alpha subunit [Escherichia coli SE11], gi\|209911133\|d... gi\|253972597, gi... - gi\|254160696\|ref\|YP_003043804.1\| citrate lyase, citrate-ACP transferase (alpha) subunit [Escherichia... gi\|218553158, gi... - gi\|218553158\|ref\|YP_002386071.1\| citrate lyase, citrate-ACP transferase (alpha) subunit [Escherichia... gi\|253325444, gi... - gi\|254287484\|ref\|YP_003053232.1\| citrate lyase, citrate-ACP transferase (alpha) subunit [Escherichia... gi\|124530185, gi... - gi\|124530185\|ref\|ZP_01700934.1\| citrate lyase, alpha subunit [Escherichia coli B], gi\|124499348\|gb\|E... gi\|209777304 - gi\|209777304\|gb\|ACI86964.1\| citrate lyase alpha chain [Escherichia coli] gi\|75258648, gi\|... - gi\|75258648\|ref\|ZP_00730055.1\| COG3051: Citrate lyase, alpha subunit [Escherichia coli E22], gi\|1930... gi\|190902580, gi... - gi\|75229500\|ref\|ZP_00716047.1\| COG3051: Citrate lyase, alpha subunit [Escherichia coli B7A], gi\|1911... gi\|75189654, gi\|... - gi\|75189654\|ref\|ZP_00702921.1\| COG3051: Citrate lyase, alpha subunit [Escherichia coli E24377A], gi\|... gi\|169755954, gi... - gi\|170021026\|ref\|YP_001725980.1\| citrate lyase, alpha subunit [Escherichia coli ATCC 8739], gi\|16975...	438.0	[0..1]	[510..1]
gi\|4062232 - dbj\|BAA35251.1\| Citrate lyase alpha chain (acyl lyase subunit) (citF) homolog [Escherichia coli K12]... gi\|1778532 - gi\|1778532\|gb\|AAB40815.1\| HI0022 homolog [Escherichia coli]	438.0	[0..1]	[510..15]
gi\|218688439, gi... - gi\|218688439\|ref\|YP_002396651.1\| citrate lyase, citrate-ACP transferase (alpha) subunit [Escherichia... gi\|91209663, gi\|... - gi\|91209663\|ref\|YP_539649.1\| citrate lyase alpha chain [Escherichia coli UTI89], gi\|91071237\|gb\|ABE0... gi\|110640845, gi... - gi\|110640845\|ref\|YP_668573.1\| citrate lyase alpha chain [Escherichia coli 536], gi\|110342437\|gb\|ABG6... gi\|227884405, gi... - gi\|227884405\|ref\|ZP_04002210.1\| citrate lyase alpha chain [Escherichia coli 83972], gi\|227838491\|gb\|... gi\|190907422, gi... - gi\|75240771\|ref\|ZP_00724678.1\| COG3051: Citrate lyase, alpha subunit [Escherichia coli F11], gi\|1911... gi\|26246596, gi\|... - gi\|26246596\|ref\|NP_752635.1\| citrate lyase alpha chain [Escherichia coli CFT073], gi\|26106995\|gb\|AAN... gi\|215263729, gi... - gi\|215485657\|ref\|YP_002328088.1\| citrate lyase, citrate-ACP transferase (alpha) subunit [Escherichia... gi\|218364324, gi... - gi\|218557555\|ref\|YP_002390468.1\| citrate lyase, citrate-ACP transferase (alpha) subunit [Escherichia...	438.0	[0..1]	[510..1]
gi\|157160111, gi... - gi\|75194799\|ref\|ZP_00704869.1\| COG3051: Citrate lyase, alpha subunit [Escherichia coli HS], gi\|15716...	437.0	[0..1]	[510..1]
gi\|81244474, gi\|... - gi\|82543063\|ref\|YP_407010.1\| citrate lyase alpha chain [Shigella boydii Sb227], gi\|81244474\|gb\|ABB65...	437.0	[0..1]	[510..1]
gi\|62126853, gi\|... - gi\|62179220\|ref\|YP_215637.1\| citrate lyase alpha chain/citrate-ACP transferase [Salmonella enterica ...	437.0	[0..1]	[510..1]

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Predicted Domain #1

Region A:
Residues: [1-510]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTQKIEQSQR QERVAAWNRR AECDLAAFQN SPKQTYQAEK ARDRKLCANL EEAIRRSGLQ  60
   61 DGMTVSFHHA FRGGDLTVNM VMDVIAKMGF KNLTLASSSL SDCHAPLVEH IRQGVVTRIY 120
  121 TSGLRGPLAE EISRGLLAEP VQIHSHGGRV HLVQSGELNI DVAFLGVPSC DEFGNANGYT 180
  181 GKACCGSLGY AIVDADNAKQ VVMLTEELLP YPHNPASIEQ DQVDLIVKVD RVGDAAKIGA 240
  241 GATRMTTNPR ELLIARSAAD VIVNSGYFKE GFSMQTGTGG ASLAVTRFLE DKMRSRDIRA 300
  301 DFALGGITAT MVDLHEKGLI RKLLDVQSFD SHAAQSLARN PNHIEISANQ YANWGSKGAS 360
  361 VDRLDVVVLS ALEIDTQFNV NVLTGSDGVL RGASGGHCDT AIASALSIIV APLVRGRIPT 420
  421 LVDNVLTCIT PGSSVDILVT DHGIAVNPAR PELAERLQEA GIKVVSIEWL RERARLLTGE 480
  481 PQPIEFTDRV VAVVRYRDGS VIDVVHQVKE

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	120.0
Match:	1xr4A
Description:	X-ray crystal structure of putative citrate lyase alpha chain/citrate-ACP transferase [Salmonella typhimurium]
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
citrate (pro-3S)-lyase activity	5.72189815717429	bayes_pls_golite062009
catalytic activity	1.31732715713197	bayes_pls_golite062009
intramolecular oxidoreductase activity	0.71386879172796	bayes_pls_golite062009
oxo-acid-lyase activity	0.617762098357868	bayes_pls_golite062009
intramolecular oxidoreductase activity, interconverting aldoses and ketoses	0.197609066179683	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: