YRC Public Data Repository - Protein Structure Prediction

Protein:	ASNA_ECOLI
Organism:	Escherichia coli
Length:	330 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ASNA_ECOLI.

Description	E-value	Query Range	Subject Range
ASNA_STRA1 - Aspartate--ammonia ligase OS=Streptococcus agalactiae serotype Ia (strain ATCC 27591 / A909 / CDC SS... ASNA_STRA5 - Aspartate--ammonia ligase OS=Streptococcus agalactiae serotype V GN=asnA PE=3 SV=1 ASNA_STRA1 - Aspartate--ammonia ligase OS=Streptococcus agalactiae serotype Ia GN=asnA PE=3 SV=1 ASNA_STRA5 - Aspartate--ammonia ligase OS=Streptococcus agalactiae serotype V (strain ATCC BAA-611 / 2603 V/R) GN...	598.0	[0..1]	[330..1]
ASNA_STRA3 - Aspartate--ammonia ligase OS=Streptococcus agalactiae serotype III (strain NEM316) GN=asnA PE=3 SV=1 ASNA_STRA3 - Aspartate--ammonia ligase OS=Streptococcus agalactiae serotype III GN=asnA PE=3 SV=1	597.0	[0..1]	[330..1]
gi\|53733087 - gi\|53733087\|ref\|ZP_00155556.2\| COG2502: Asparagine synthetase A [Haemophilus influenzae R2846] gi\|145269342, gi... - gi\|145637396\|ref\|ZP_01793055.1\| asparagine synthetase AsnA [Haemophilus influenzae PittHH], gi\|14526...	597.0	[0..1]	[330..1]
ASNA_ACTPJ - Aspartate--ammonia ligase OS=Actinobacillus pleuropneumoniae serotype 3 (strain JL03) GN=asnA PE=3 S... ASNA_ACTP7 - Aspartate--ammonia ligase OS=Actinobacillus pleuropneumoniae serotype 7 (strain AP76) GN=asnA PE=3 S... gi\|46143487 - gi\|46143487\|ref\|ZP_00135167.2\| COG2502: Asparagine synthetase A [Actinobacillus pleuropneumoniae ser... ASNA_ACTP2 - Aspartate--ammonia ligase OS=Actinobacillus pleuropneumoniae serotype 5b (strain L20) GN=asnA PE=3 S...	596.0	[0..1]	[330..1]
gi\|76797768, gi\|... - gi\|76797768\|ref\|ZP_00780035.1\| aspartate--ammonia ligase [Streptococcus agalactiae 18RS21], gi\|76586...	596.0	[0..1]	[330..1]
ASNA_STRPN - Aspartate--ammonia ligase OS=Streptococcus pneumoniae GN=asnA PE=3 SV=1 ASNA_STRZJ - Aspartate--ammonia ligase OS=Streptococcus pneumoniae (strain JJA) GN=asnA PE=3 SV=1 ASNA_STRZP - Aspartate--ammonia ligase OS=Streptococcus pneumoniae (strain P1031) GN=asnA PE=3 SV=1 ASNA_STRP7 - Aspartate--ammonia ligase OS=Streptococcus pneumoniae (strain 70585) GN=asnA PE=3 SV=1 ASNA_STRZT - Aspartate--ammonia ligase OS=Streptococcus pneumoniae (strain Taiwan19F-14) GN=asnA PE=3 SV=1 gi\|237650989 - gi\|237650989\|ref\|ZP_04525241.1\| asparagine synthetase AsnA [Streptococcus pneumoniae CCRI 1974] gi\|237821626 - gi\|237821626\|ref\|ZP_04597471.1\| asparagine synthetase AsnA [Streptococcus pneumoniae CCRI 1974M2] gi\|242244282, gi... - gi\|242244282\|ref\|ZP_04798719.1\| aspartate--ammonia ligase [Streptococcus pneumoniae TCH8431/19A], gi... gi\|172042516, gi... - gi\|172042516\|gb\|EDT50562.1\| aspartate--ammonia ligase [Streptococcus pneumoniae CDC1873-00], gi\|1684... ASNA_STRPJ - Aspartate--ammonia ligase OS=Streptococcus pneumoniae (strain ATCC 700669 / Spain 23F-1) GN=asnA PE=... gi\|168489975, gi... - gi\|183571616\|gb\|EDT92144.1\| aspartate--ammonia ligase [Streptococcus pneumoniae SP195], gi\|168489975... gi\|183569978, gi... - gi\|183569978\|gb\|EDT90506.1\| aspartate--ammonia ligase [Streptococcus pneumoniae CDC1087-00], gi\|1684... gi\|183575315, gi... - gi\|183575315\|gb\|EDT95843.1\| aspartate--ammonia ligase [Streptococcus pneumoniae CDC3059-06], gi\|1684... gi\|168492055, gi... - gi\|183573716\|gb\|EDT94244.1\| aspartate--ammonia ligase [Streptococcus pneumoniae CDC0288-04], gi\|1684... ASNA_STRPI - Aspartate--ammonia ligase OS=Streptococcus pneumoniae (strain Hungary19A-6) GN=asnA PE=3 SV=1 gi\|168576629, gi... - gi\|183577644\|gb\|EDT98172.1\| aspartate--ammonia ligase [Streptococcus pneumoniae MLV-016], gi\|1685766... ASNA_STRP4 - Aspartate--ammonia ligase OS=Streptococcus pneumoniae serotype 19F (strain G54) GN=asnA PE=3 SV=1 ASNA_STRPS - Aspartate--ammonia ligase OS=Streptococcus pneumoniae (strain CGSP14) GN=asnA PE=3 SV=1 gi\|147929959, gi... - gi\|149021921\|ref\|ZP_01835908.1\| asparagine synthetase AsnA [Streptococcus pneumoniae SP23-BS72], gi\|... gi\|147763496, gi... - gi\|149012440\|ref\|ZP_01833471.1\| asparagine synthetase AsnA [Streptococcus pneumoniae SP19-BS75], gi\|... gi\|149007445, gi... - gi\|149007445\|ref\|ZP_01831088.1\| asparagine synthetase AsnA [Streptococcus pneumoniae SP18-BS74], gi\|... gi\|147758361, gi... - gi\|149003629\|ref\|ZP_01828494.1\| asparagine synthetase AsnA [Streptococcus pneumoniae SP14-BS69], gi\|... gi\|147755694, gi... - gi\|148998501\|ref\|ZP_01825942.1\| asparagine synthetase AsnA [Streptococcus pneumoniae SP11-BS70], gi\|... gi\|148993169, gi... - gi\|148993169\|ref\|ZP_01822735.1\| asparagine synthetase AsnA [Streptococcus pneumoniae SP9-BS68], gi\|1... gi\|148985550, gi... - gi\|148985550\|ref\|ZP_01818739.1\| asparagine synthetase AsnA [Streptococcus pneumoniae SP3-BS71], gi\|1... ASNA_STRPN - Aspartate--ammonia ligase OS=Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4) GN=as...	596.0	[0..1]	[330..1]
ASNA_HAEI8 - Aspartate--ammonia ligase OS=Haemophilus influenzae (strain 86-028NP) GN=asnA PE=3 SV=1	595.0	[0..1]	[330..1]
ASNA_STRP8 - Aspartate--ammonia ligase OS=Streptococcus pyogenes serotype M18 (strain MGAS8232) GN=asnA PE=3 SV=1 ASNA_STRPB - Aspartate--ammonia ligase OS=Streptococcus pyogenes serotype M12 (strain MGAS2096) GN=asnA PE=3 SV=1 ASNA_STRPQ - Aspartate--ammonia ligase OS=Streptococcus pyogenes serotype M3 (strain SSI-1) GN=asnA PE=3 SV=1 ASNA_STRP3 - Aspartate--ammonia ligase OS=Streptococcus pyogenes serotype M3 (strain ATCC BAA-595 / MGAS315) GN=a... ASNA_STRPC - Aspartate--ammonia ligase OS=Streptococcus pyogenes serotype M12 (strain MGAS9429) GN=asnA PE=3 SV=1 ASNA_STRPM - Aspartate--ammonia ligase OS=Streptococcus pyogenes serotype M28 (strain MGAS6180) GN=asnA PE=3 SV=1 ASNA_STRPF - Aspartate--ammonia ligase OS=Streptococcus pyogenes serotype M4 (strain MGAS10750) GN=asnA PE=3 SV=1 ASNA_STRPM - Aspartate--ammonia ligase OS=Streptococcus pyogenes serotype M28 GN=asnA PE=3 SV=1 ASNA_STRP3 - Aspartate--ammonia ligase OS=Streptococcus pyogenes serotype M3 GN=asnA PE=3 SV=1 ASNA_STRP8 - Aspartate--ammonia ligase OS=Streptococcus pyogenes serotype M18 GN=asnA PE=3 SV=1	594.0	[0..1]	[330..1]
gi\|15903827, gi\|... - gi\|15903827\|ref\|NP_359377.1\| asparagine synthetase AsnA [Streptococcus pneumoniae R6], gi\|15459469\|g... gi\|25293479 - gi\|25293479\|pir\|\|G98094 aspartate-ammonia ligase (EC 6.3.1.1) [imported] - Streptococcus pneumoniae ...	594.0	[0..1]	[330..3]
ASNA_STRPY - (Q99YU0) Aspartate--ammonia ligase (EC 6.3.1.1) (Asparagine synthetase A) gi\|71853864, gi\|... - gi\|71911082\|ref\|YP_282632.1\| asparagine synthetase AsnA [Streptococcus pyogenes MGAS5005], gi\|718538... gi\|15675438, gi\|... - gi\|15675438\|ref\|NP_269612.1\| asparagine synthetase AsnA [Streptococcus pyogenes M1 GAS], gi\|13622628... ASNA_STRP1 - Aspartate--ammonia ligase OS=Streptococcus pyogenes serotype M1 GN=asnA PE=3 SV=1	593.0	[0..1]	[330..1]

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Predicted Domain #1

Region A:
Residues: [1-330]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKTAYIAKQR QISFVKSHFS RQLEERLGLI EVQAPILSRV GDGTQDNLSG CEKAVQVKVK  60
   61 ALPDAQFEVV HSLAKWKRQT LGQHDFSAGE GLYTHMKALR PDEDRLSPLH SVYVDQWDWE 120
  121 RVMGDGERQF STLKSTVEAI WAGIKATEAA VSEEFGLAPF LPDQIHFVHS QELLSRYPDL 180
  181 DAKGRERAIA KDLGAVFLVG IGGKLSDGHR HDVRAPDYDD WSTPSELGHA GLNGDILVWN 240
  241 PVLEDAFELS SMGIRVDADT LKHQLALTGD EDRLELEWHQ ALLRGEMPQT IGGGIGQSRL 300
  301 TMLLLQLPHI GQVQCGVWPA AVRESVPSLL

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	167.0
Match:	11asA
Description:	Asparagine synthetase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
ligase activity, forming carbon-oxygen bonds	3.95982081475525	bayes_pls_golite062009
ligase activity, forming aminoacyl-tRNA and related compounds	3.95982081475525	bayes_pls_golite062009
aminoacyl-tRNA ligase activity	3.9592004812151	bayes_pls_golite062009
ligase activity	3.05852492533937	bayes_pls_golite062009
catalytic activity	2.36416267096403	bayes_pls_golite062009
phenylalanine-tRNA ligase activity	0.27932659689192	bayes_pls_golite062009
serine-tRNA ligase activity	0.15245558407217	bayes_pls_golite062009
threonine-tRNA ligase activity	0.0873863095068197	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: