YRC Public Data Repository - Protein Structure Prediction

Protein:	AROF_ECOLI
Organism:	Escherichia coli
Length:	356 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for AROF_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|37678885, gi\|... - gi\|37678885\|ref\|NP_933494.1\| phospho-2-dehydro-3-deoxyheptonate aldolase [Vibrio vulnificus YJ016], ...	450.0	[0..1]	[355..59]
gi\|73854749, gi\|... - gi\|74311272\|ref\|YP_309691.1\| phospho-2-dehydro-3-deoxyheptonate aldolase [Shigella sonnei Ss046], gi...	446.0	[0..5]	[352..4]
gi\|193069560, gi... - gi\|75235771\|ref\|ZP_00719926.1\| COG0722: 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase ...	446.0	[0..5]	[352..4]
gi\|59713577, gi\|... - gi\|59713577\|ref\|YP_206352.1\| phospho-2-dehydro-3-deoxyheptonate aldolase [Vibrio fischeri ES114], gi...	446.0	[0..5]	[353..3]
gi\|75237090, gi\|... - gi\|75237090\|ref\|ZP_00721144.1\| COG0722: 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase ... gi\|110640955, gi... - gi\|110640955\|ref\|YP_668683.1\| phospho-2-dehydro-3-deoxyheptonate aldolase [Escherichia coli 536], gi...	446.0	[0..5]	[352..4]
gi\|62126962, gi\|... - gi\|62179329\|ref\|YP_215746.1\| 3-deoxy-7-phosphoheptulonate synthase [Salmonella enterica subsp. enter...	444.0	[0..5]	[352..47]
gi\|50120320, gi\|... - gi\|50120320\|ref\|YP_049487.1\| phospho-2-dehydro-3-deoxyheptonate aldolase [Pectobacterium atrosepticu...	444.0	[0..5]	[353..4]
gi\|30040334, gi\|... - gi\|30062090\|ref\|NP_836261.1\| phospho-2-dehydro-3-deoxyheptonate aldolase [Shigella flexneri 2a str. ... gi\|24111977, gi\|... - gi\|24111977\|ref\|NP_706487.1\| phospho-2-dehydro-3-deoxyheptonate aldolase [Shigella flexneri 2a str. ... gi\|110614175, gi... - gi\|110804627\|ref\|YP_688147.1\| phospho-2-dehydro-3-deoxyheptonate aldolase [Shigella flexneri 5 str. ...	444.0	[0..5]	[352..4]
gi\|126637295, gi... - gi\|78368661\|ref\|ZP_00838876.1\| Phospho-2-dehydro-3-deoxyheptonate aldolase, subtype 1 [Shewanella sp...	444.0	[0..1]	[356..1]
gi\|84360842, gi\|... - gi\|84360842\|ref\|ZP_00985530.1\| COG0722: 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase ...	444.0	[0..1]	[356..1]

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Predicted Domain #1

Region A:
Residues: [1-356]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MQKDALNNVH ITDEQVLMTP EQLKAAFPLS LQQEAQIADS RKSISDIIAG RDPRLLVVCG  60
   61 PCSIHDPETA LEYARRFKAL AAEVSDSLYL VMRVYFEKPR TTVGWKGLIN DPHMDGSFDV 120
  121 EAGLQIARKL LLELVNMGLP LATEALDPNS PQYLGDLFSW SAIGARTTES QTHREMASGL 180
  181 SMPVGFKNGT DGSLATAINA MRAAAQPHRF VGINQAGQVA LLQTQGNPDG HVILRGGKAP 240
  241 NYSPADVAQC EKEMEQAGLR PSLMVDCSHG NSNKDYRRQP AVAESVVAQI KDGNRSIIGL 300
  301 MIESNIHEGN QSSEQPRSEM KYGVSVTDAC ISWEMTDALL REIHQDLNGQ LTARVA

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	125.0
Match:	1gg1A
Description:	3-deoxy-D-arabino-heptulosonate-7-phosphate synthase (DAHP synthase, AroG)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
3-deoxy-7-phosphoheptulonate synthase activity	2.72022882819661	bayes_pls_golite062009
catalytic activity	2.67031204377352	bayes_pls_golite062009
dihydrodipicolinate synthase activity	1.2687335039487	bayes_pls_golite062009
lyase activity	0.740424046054758	bayes_pls_golite062009
transferase activity, transferring aldehyde or ketonic groups	0.719960432098845	bayes_pls_golite062009
oxo-acid-lyase activity	0.606352769346285	bayes_pls_golite062009
ligase activity, forming carbon-carbon bonds	0.490222900376021	bayes_pls_golite062009
transferase activity	0.464721888799972	bayes_pls_golite062009
carbon-carbon lyase activity	0.36754360512349	bayes_pls_golite062009
3-deoxy-8-phosphooctulonate synthase activity	0.0356008407895519	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: