YRC Public Data Repository - Protein Structure Prediction

Protein:	APHA_ECOLI
Organism:	Escherichia coli
Length:	237 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for APHA_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|75238591 - gi\|75238591\|ref\|ZP_00722580.1\| COG3700: Acid phosphatase (class B) [Escherichia coli E110019] gi\|209921540, gi... - gi\|209921540\|ref\|YP_002295624.1\| acid phosphatase/phosphotransferase [Escherichia coli SE11], gi\|209... gi\|187730314, gi... - gi\|187730314\|ref\|YP_001882747.1\| class B acid phosphatase [Shigella boydii CDC 3083-94], gi\|18742730...	303.0	[0..1]	[237..1]
gi\|208812480, gi... - gi\|208812480\|ref\|ZP_03253809.1\| HAD-superfamily phosphatase, subfamily IIIB [Escherichia coli O157:H... gi\|208726661, gi... - gi\|208806860\|ref\|ZP_03249197.1\| HAD-superfamily phosphatase, subfamily IIIB [Escherichia coli O157:H... gi\|195935839 - gi\|195935839\|ref\|ZP_03081221.1\| acid phosphatase/phosphotransferase [Escherichia coli O157:H7 str. E... gi\|168798284, gi... - gi\|189379227\|gb\|EDU97643.1\| class B acid phosphatase [Escherichia coli O157:H7 str. EC508], gi\|16879... gi\|217326014, gi... - gi\|217326014\|ref\|ZP_03442098.1\| HAD-superfamily phosphatase, subfamily IIIB [Escherichia coli O157:... gi\|209400146, gi... - gi\|209400146\|ref\|YP_002273595.1\| HAD-superfamily phosphatase, subfamily IIIB [Escherichia coli O157:... gi\|13364514, gi\|... - gi\|15834291\|ref\|NP_313064.1\| acid phosphatase/phosphotransferase [Escherichia coli O157:H7 str. Saka... gi\|208820927, gi... - gi\|208820927\|ref\|ZP_03261247.1\| HAD-superfamily phosphatase, subfamily IIIB [Escherichia coli O157:H... gi\|189368588, gi... - gi\|189368588\|gb\|EDU87004.1\| class B acid phosphatase [Escherichia coli O157:H7 str. EC4501], gi\|1687... gi\|189357525, gi... - gi\|189357525\|gb\|EDU75944.1\| class B acid phosphatase [Escherichia coli O157:H7 str. EC4401], gi\|1687... gi\|188017453, gi... - gi\|188017453\|gb\|EDU55575.1\| class B acid phosphatase [Escherichia coli O157:H7 str. EC4113], gi\|1687... gi\|189375166, gi... - gi\|189375166\|gb\|EDU93582.1\| class B acid phosphatase [Escherichia coli O157:H7 str. EC869], gi\|16878... gi\|189001870, gi... - gi\|189001870\|gb\|EDU70856.1\| class B acid phosphatase [Escherichia coli O157:H7 str. EC4076], gi\|1687... gi\|168774411, gi... - gi\|187769934\|gb\|EDU33778.1\| class B acid phosphatase [Escherichia coli O157:H7 str. EC4196], gi\|1687... gi\|189364079, gi... - gi\|189364079\|gb\|EDU82498.1\| class B acid phosphatase [Escherichia coli O157:H7 str. EC4486], gi\|1687... gi\|13364514, gi\|... - gi\|15834291\|ref\|NP_313064.1\| diadenosine tetraphosphatase [Escherichia coli O157:H7], gi\|13364514\|db... gi\|25354471, gi\|... - pir\|\|A86099 diadenosine tetraphosphatase [imported] - Escherichia coli (strain O157:H7, substrain E... gi\|15804647, gi\|... - gi\|15804647\|ref\|NP_290688.1\| acid phosphatase/phosphotransferase [Escherichia coli O157:H7 EDL933], ... gi\|254796075, gi... - gi\|254796075\|ref\|YP_003080912.1\| acid phosphatase/phosphotransferase, class B, non-specific [Escheri...	302.0	[0..1]	[237..1]
gi\|75188779, gi\|... - gi\|75188779\|ref\|ZP_00702046.1\| COG3700: Acid phosphatase (class B) [Escherichia coli E24377A], gi\|15...	302.0	[0..1]	[237..1]
gi\|75241095 - gi\|75241095\|ref\|ZP_00724969.1\| COG3700: Acid phosphatase (class B) [Escherichia coli F11] gi\|218561138, gi... - gi\|218561138\|ref\|YP_002394051.1\| acid phosphatase/phosphotransferase [Escherichia coli S88], gi\|2183... gi\|26250857, gi\|... - gi\|26250857\|ref\|NP_756897.1\| acid phosphatase/phosphotransferase [Escherichia coli CFT073], gi\|26111... gi\|91075168, gi\|... - gi\|91213594\|ref\|YP_543580.1\| acid phosphatase/phosphotransferase [Escherichia coli UTI89], gi\|910751... gi\|110345994, gi... - gi\|110644402\|ref\|YP_672132.1\| acid phosphatase/phosphotransferase [Escherichia coli 536], gi\|1103459... gi\|215267473, gi... - gi\|215489401\|ref\|YP_002331832.1\| acid phosphatase/phosphotransferase [Escherichia coli O127:H6 str. ...	302.0	[0..1]	[237..1]
gi\|226840160, gi... - gi\|254037054\|ref\|ZP_04871131.1\| diadenosine tetraphosphatase [Escherichia sp. 1_1_43], gi\|226840160\|... gi\|24115354, gi\|... - ref\|NP_709864.1\| diadenosine tetraphosphatase [Shigella flexneri 2a str. 301], gb\|AAN45571.1\| diade... gi\|110807928, gi... - gi\|110807928\|ref\|YP_691448.1\| acid phosphatase/phosphotransferase [Shigella flexneri 5 str. 8401], g... gi\|194426828, gi... - gi\|194426828\|ref\|ZP_03059381.1\| class B acid phosphatase [Escherichia coli B171], gi\|194415164\|gb\|ED... tr\|A0A0G3HTT7\|A0... - Acid phosphatase/phosphotransferase, class B,non-specific protein OS=Escherichia coli (strain K12) G...	301.0	[0..1]	[237..81]
gi\|191172017, gi... - gi\|191172017\|ref\|ZP_03033562.1\| class B acid phosphatase [Escherichia coli F11], gi\|190907782\|gb\|EDV... gi\|115515460, gi... - gi\|117626336\|ref\|YP_859659.1\| acid phosphatase/phosphotransferase [Escherichia coli APEC O1], gi\|115... gi\|227836064, gi... - gi\|227886923\|ref\|ZP_04004728.1\| acid phosphatase/phosphotransferase [Escherichia coli 83972], gi\|227... gi\|226901540, gi... - gi\|237703628\|ref\|ZP_04534109.1\| diadenosine tetraphosphatase [Escherichia sp. 3_2_53FAA], gi\|2269015...	300.0	[0..1]	[237..24]
gi\|167552525, gi... - gi\|205322856\|gb\|EDZ10695.1\| had superfamily (subfamily iiib) phosphatase [Salmonella enterica subsp.... gi\|168236942, gi... - gi\|197290045\|gb\|EDY29404.1\| had superfamily (subfamily iiib) phosphatase [Salmonella enterica subsp.... gi\|194734461, gi... - gi\|194734461\|ref\|YP_002117183.1\| had superfamily (subfamily iiib) phosphatase [Salmonella enterica s... APHA_SALTI - Class B acid phosphatase OS=Salmonella typhi GN=aphA PE=3 SV=2 gi\|214000145 - gi\|214000145\|ref\|ZP_03410880.1\| acid phosphatase/phosphotransferase [Salmonella enterica subsp. ente... gi\|56416049, gi\|... - gi\|56416049\|ref\|YP_153124.1\| acid phosphatase/phosphotransferase [Salmonella enterica subsp. enteric... gi\|213585854 - gi\|213585854\|ref\|ZP_03367680.1\| acid phosphatase/phosphotransferase [Salmonella enterica subsp. ente... gi\|213617519 - gi\|213617519\|ref\|ZP_03372345.1\| acid phosphatase/phosphotransferase [Salmonella enterica subsp. ente... gi\|213647522 - gi\|213647522\|ref\|ZP_03377575.1\| acid phosphatase/phosphotransferase [Salmonella enterica subsp. ente... gi\|213855878 - gi\|213855878\|ref\|ZP_03384118.1\| acid phosphatase/phosphotransferase [Salmonella enterica subsp. ente... gi\|29144417, gi\|... - gi\|29144417\|ref\|NP_807759.1\| acid phosphatase/phosphotransferase [Salmonella enterica subsp. enteric... gi\|197364976, gi... - gi\|197364976\|ref\|YP_002144613.1\| acid phosphatase/phosphotransferase [Salmonella enterica subsp. ent... gi\|16762930 - gi\|16762930\|ref\|NP_458547.1\| acid phosphatase/phosphotransferase [Salmonella enterica subsp. enteric... gi\|204323905, gi... - gi\|204927240\|ref\|ZP_03218442.1\| had superfamily (subfamily iiib) phosphatase [Salmonella enterica su... gi\|213051933 - gi\|213051933\|ref\|ZP_03344811.1\| acid phosphatase/phosphotransferase [Salmonella enterica subsp. ente... APHA_SALTI - Class B acid phosphatase OS=Salmonella typhi GN=aphA PE=1 SV=2 gi\|213424516 - gi\|213424516\|ref\|ZP_03357313.1\| acid phosphatase/phosphotransferase [Salmonella enterica subsp. ente...	294.0	[0..1]	[237..1]
gi\|197250822, gi... - gi\|197250822\|ref\|YP_002149162.1\| had superfamily (subfamily iiib) phosphatase [Salmonella enterica s... gi\|194470518, gi... - gi\|194470518\|ref\|ZP_03076502.1\| had superfamily (subfamily iiib) phosphatase [Salmonella enterica su... gi\|198242510, gi... - gi\|198242510\|ref\|YP_002218144.1\| had superfamily (subfamily iiib) phosphatase [Salmonella enterica s... gi\|197265286, gi... - gi\|197265286\|ref\|ZP_03165360.1\| had superfamily (subfamily iiib) phosphatase [Salmonella enterica su... gi\|168466933, gi... - gi\|195630555\|gb\|EDX49167.1\| had superfamily (subfamily iiib) phosphatase [Salmonella enterica subsp.... gi\|205348046, gi... - gi\|205348046\|gb\|EDZ34677.1\| had superfamily (subfamily iiib) phosphatase [Salmonella enterica subsp.... gi\|194446762, gi... - gi\|194446762\|ref\|YP_002043500.1\| had superfamily (subfamily iiib) phosphatase [Salmonella enterica s... gi\|168821305, gi... - gi\|205342054\|gb\|EDZ28818.1\| had superfamily (subfamily iiib) phosphatase [Salmonella enterica subsp.... gi\|161366743, gi... - gi\|161617379\|ref\|YP_001591344.1\| acid phosphatase/phosphotransferase [Salmonella enterica subsp. ent... lcl\|NC_016856.1_... - [gene=aphA] [protein=acid phosphatase/phosphotransferase] [protein_id=YP_005240542.1] [location=4484... gi\|168231247, gi... - gi\|205334262\|gb\|EDZ21026.1\| had superfamily (subfamily iiib) phosphatase [Salmonella enterica subsp.... APHA_SALTM - Class B acid phosphatase OS=Salmonella typhimurium GN=aphA PE=1 SV=1 gi\|167991440, gi... - gi\|205330178\|gb\|EDZ16942.1\| had superfamily (subfamily iiib) phosphatase [Salmonella enterica subsp.... gi\|238913002 - gi\|238913002\|ref\|ZP_04656839.1\| acid phosphatase/phosphotransferase [Salmonella enterica subsp. ente... APHA_SALTY - Class B acid phosphatase OS=Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) GN=aphA PE=... gi\|62182698, gi\|... - gi\|62182698\|ref\|YP_219115.1\| acid phosphatase/phosphotransferase [Salmonella enterica subsp. enteric... APHA_SALTY - Class B acid phosphatase OS=Salmonella typhimurium GN=aphA PE=1 SV=1 gi\|205274802, gi... - gi\|205355021\|ref\|YP_002228822.1\| acid phosphatase/phosphotransferase [Salmonella enterica subsp. ent... gi\|199604545, gi... - gi\|200387447\|ref\|ZP_03214059.1\| had superfamily (subfamily iiib) phosphatase [Salmonella enterica su... gi\|224586014, gi... - gi\|224586014\|ref\|YP_002639813.1\| class B acid phosphatase precursor [Salmonella enterica subsp. ente... gi\|207859403, gi... - gi\|207859403\|ref\|YP_002246054.1\| acid phosphatase/phosphotransferase [Salmonella enterica subsp. ent...	294.0	[0..1]	[237..1]
gi\|56694136\|gb\|A... - AphA [Salmonella typhimurium] gi\|56694136 - gi\|56694136\|gb\|AAW22868.1\| AphA [Salmonella typhimurium]	294.0	[0..1]	[237..1]
gi\|4586230 - gi\|4586230\|emb\|CAB40974.1\| class B acid phosphatase AphA [Salmonella enterica]	289.0	[0..1]	[237..1]

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Predicted Domain #1

Region A:
Residues: [1-237]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRKITQAISA VCLLFALNSS AVALASSPSP LNPGTNVARL AEQAPIHWVS VAQIENSLAG  60
   61 RPPMAVGFDI DDTVLFSSPG FWRGKKTFSP ESEDYLKNPV FWEKMNNGWD EFSIPKEVAR 120
  121 QLIDMHVRRG DAIFFVTGRS PTKTETVSKT LADNFHIPAT NMNPVIFAGD KPGQNTKSQW 180
  181 LQDKNIRIFY GDSDNDITAA RDVGARGIRI LRASNSTYKP LPQAGAFGEE VIVNSEY

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	72.522879
Match:	1n8nA
Description:	Crystal structure of the Au3+ complex of AphA class B acid phosphatase/phosphotransferase from E. coli at 1.69 A resolution
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
catalytic activity	1.02290994020378	bayes_pls_golite062009
hydrolase activity	0.71914501009647	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: