YRC Public Data Repository - Protein Structure Prediction

Protein:	ALLD_ECOLI
Organism:	Escherichia coli
Length:	349 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ALLD_ECOLI.

Description	E-value	Query Range	Subject Range
MDH_PYRAB - Malate dehydrogenase OS=Pyrococcus abyssi GN=mdh PE=3 SV=1 MDH_PYRAB - Malate dehydrogenase OS=Pyrococcus abyssi (strain GE5 / Orsay) GN=mdh PE=3 SV=1	415.0	[0..1]	[340..12]
gi\|89089635, gi\|... - gi\|89095889\|ref\|ZP_01168783.1\| hypothetical protein B14911_04129 [Bacillus sp. NRRL B-14911], gi\|890...	412.0	[0..1]	[333..4]
MDH_PYRHO - Malate dehydrogenase OS=Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 1001... MDH_PYRHO - Malate dehydrogenase OS=Pyrococcus horikoshii GN=mdh PE=1 SV=1	410.0	[0..1]	[341..12]
gi\|71002066, gi\|... - gi\|71002066\|ref\|XP_755714.1\| malate/L-lactate dehydrogenase [Aspergillus fumigatus Af293], gi\|668533... gi\|159129771 - gi\|159129771\|gb\|EDP54885.1\| malate/L-lactate dehydrogenase, putative [Aspergillus fumigatus A1163]	407.0	[0..1]	[342..8]
MDH_METFV - Malate/(S)-sulfolactate dehydrogenase OS=Methanothermus fervidus (strain ATCC 43054 / DSM 2088 / JCM... MDH_METFE - Malate/L-sulfolactate dehydrogenase OS=Methanothermus fervidus GN=mdh PE=1 SV=2	405.0	[0..1]	[344..1]
gi\|29138356, gi\|... - gi\|29142725\|ref\|NP_806067.1\| ureidoglycolate dehydrogenase [Salmonella enterica subsp. enterica sero... gi\|213581051 - gi\|213581051\|ref\|ZP_03362877.1\| ureidoglycolate dehydrogenase [Salmonella enterica subsp. enterica s... gi\|16759503 - gi\|16759503\|ref\|NP_455120.1\| ureidoglycolate dehydrogenase [Salmonella enterica subsp. enterica sero... gi\|213647070 - gi\|213647070\|ref\|ZP_03377123.1\| ureidoglycolate dehydrogenase [Salmonella enterica subsp. enterica s... gi\|213855432 - gi\|213855432\|ref\|ZP_03383672.1\| ureidoglycolate dehydrogenase [Salmonella enterica subsp. enterica s... gi\|16501795, gi\|... - gi\|25325329\|pir\|\|AB0568 ureidoglycolate dehydrogenase (EC 1.1.1.154) [imported] - Salmonella enteric... gi\|213999559 - gi\|213999559\|ref\|ZP_03410294.1\| ureidoglycolate dehydrogenase [Salmonella enterica subsp. enterica s... gi\|213427925 - gi\|213427925\|ref\|ZP_03360675.1\| ureidoglycolate dehydrogenase [Salmonella enterica subsp. enterica s...	404.0	[0..1]	[349..1]
gi\|194459155, gi... - gi\|194472791\|ref\|ZP_03078775.1\| ureidoglycolate dehydrogenase [Salmonella enterica subsp. enterica s... gi\|168465631, gi... - gi\|195631981\|gb\|EDX50501.1\| ureidoglycolate dehydrogenase [Salmonella enterica subsp. enterica serov... gi\|205334013, gi... - gi\|205334013\|gb\|EDZ20777.1\| ureidoglycolate dehydrogenase [Salmonella enterica subsp. enterica serov... gi\|56128577, gi\|... - gi\|56414320\|ref\|YP_151395.1\| ureidoglycolate dehydrogenase [Salmonella enterica subsp. enterica sero... gi\|197363240, gi... - gi\|197363240\|ref\|YP_002142877.1\| ureidoglycolate dehydrogenase [Salmonella enterica subsp. enterica ...	404.0	[0..1]	[349..1]
gi\|200390772, gi... - gi\|200390772\|ref\|ZP_03217383.1\| ureidoglycolate dehydrogenase [Salmonella enterica subsp. enterica s... lcl\|NC_016856.1_... - [gene=allD] [protein=ureidoglycolate dehydrogenase] [protein_id=YP_005236231.1] [location=complement... gi\|205330860, gi... - gi\|205330860\|gb\|EDZ17624.1\| ureidoglycolate dehydrogenase [Salmonella enterica subsp. enterica serov... gi\|197938552, gi... - gi\|198244036\|ref\|YP_002214483.1\| ureidoglycolate dehydrogenase [Salmonella enterica subsp. enterica ... gi\|16763908, gi\|... - gi\|16763908\|ref\|NP_459523.1\| ureidoglycolate dehydrogenase [Salmonella typhimurium LT2], gi\|16419038...	403.0	[0..1]	[349..1]
gi\|75257843, gi\|... - gi\|75257843\|ref\|ZP_00729321.1\| COG2055: Malate/L-lactate dehydrogenases [Escherichia coli E22], gi\|1... gi\|190901859, gi... - gi\|75228709\|ref\|ZP_00715326.1\| COG2055: Malate/L-lactate dehydrogenases [Escherichia coli B7A], gi\|1... gi\|75209179, gi\|... - gi\|75209179\|ref\|ZP_00709430.1\| COG2055: Malate/L-lactate dehydrogenases [Escherichia coli B171], gi\|...	402.0	[0..1]	[349..1]

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Predicted Domain #1

Region A:
Residues: [1-349]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKISRETLHQ LIENKLCQAG LKREHAATVA EVLVYADARG IHSHGAVRVE YYAERISKGG  60
   61 TNREPEFRLE ETGPCSAILH ADNAAGQVAA KMGMEHAIKT AQQNGVAVVG ISRMGHSGAI 120
  121 SYFVQQAARA GFIGISMCQS DPMVVPFGGA EIYYGTNPLA FAAPGEGDEI LTFDMATTVQ 180
  181 AWGKVLDARS RNMSIPDTWA VDKNGVPTTD PFAVHALLPA AGPKGYGLMM MIDVLSGVLL 240
  241 GLPFGRQVSS MYDDLHAGRN LGQLHIVINP NFFSSSELFR QHLSQTMREL NAITPAPGFN 300
  301 QVYYPGQDQD IKQRKAAVEG IEIVDDIYQY LISDALYNTS YETKNPFAQ

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	112.0
Match:	1xrhA
Description:	Crystal Structure of Ureidoglycolate Dehydrogenase from Escherichia Coli
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
ureidoglycolate dehydrogenase activity	2.31296605024948	bayes_pls_golite062009
catalytic activity	1.46550169341481	bayes_pls_golite062009
oxidoreductase activity	0.85331060838129	bayes_pls_golite062009
oxidoreductase activity, acting on CH-OH group of donors	0.39638635836583	bayes_pls_golite062009
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	0.0391859309886404	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: