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View Structure Prediction Details

Protein: ptc-2
Organism: Caenorhabditis elegans
Length: 667 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ptc-2.

Description E-value Query
Range
Subject
Range
gi|38649260 - gi|38649260|gb|AAH63302.1| Niemann-Pick disease, type C1 [Homo sapiens]
294.0 [0..7] [666..520]

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Predicted Domain #1
Region A:
Residues: [1-523]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSENMYPQNV DYAAEMTGGC SGFASNVLNW PEDMILGNPR RAKKGGKLSG ADALQFVFLV  60
   61 ASPADVFLRF KQSLEETLET LSLYEEHCIH LHRHPLLICS RNSVNSTIPS SLLDMLSCWH 120
  121 MLLLLILDLT TAFRLQNHQW GFALAGVLVV TFASVAGIGL ATWFGIEFNA ATTQIVPFLT 180
  181 LGIGVDNMFM LLHNYRDVVK LAGGHAEMAI LMRETGMSIL CTSINNILSF LTGTLLPIPA 240
  241 LRSFCAQSSI LLTFNFIAIL TIYPAIISID LRRKKAQRRD FDTREESTSE ASIMQQFDGI 300
  301 TQAQMASSDD PAPWSLHSFI RYYYIPFISK PASKVAIIVG CCALLGASFV GMRQSTLGLE 360
  361 LGDVLPEHTA PAQFLRARDK YFSFYPMFAV IKGPNIDYAH QQRQIDNYRQ SIGSSKYVIK 420
  421 NKNEEPSEKY WLGLMRDWLI SIQRGFDEEV AKGSFNLTSG TVIGSNVSED ARLAHALMCS 480
  481 HGSLFECAGR IGKIRLIPFY LTGLTDTAVI VDAIKDIRSV CER

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 72.522879
Match: 1oy6A
Description: Multidrug efflux transporter AcrB pore domain; PN1, PN2, PC1 and PC2 subdomains; Multidrug efflux transporter AcrB TolC docking domain; DN and DC subdomains; Multidrug efflux transporter AcrB transmembrane domain
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [524-667]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FTDQGLPNFP QGIAFTFWEQ YLFLTGNLMQ AISIITISVF CVISVLLFNP WAALMVVCIL  60
   61 GIMTCELAGF MGLVGIKLNP VSAVTLITAV GIGVEFTVHV VVSFLTALGT RSQRTSSAVD 120
  121 RVFVPVIHGS FSTLLGILML GFSV

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle