YRC Public Data Repository - Protein Structure Prediction

Protein:	TRP1
Organism:	Saccharomyces cerevisiae
Length:	224 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for TRP1.

Description	E-value	Query Range	Subject Range
gi\|45719962, gi\|... - gi\|45719966\|emb\|CAE52201.1\| Trp1p [Saccharomyces cerevisiae], gi\|45719962\|emb\|CAE52199.1\| Trp1p [Sac...	1.0E-67	[1..224]	[1..224]
gi\|912422 - gi\|912422\|gb\|AAA72099.1\| putative. start [Cloning vector pYADE4] gi\|1052971 - gi\|1052971\|gb\|AAA80674.1\| N-(5'-phosphoribosyl)-anthranilate isomerase [Cloning vector YRTAG300] gi\|1052967 - gi\|1052967\|gb\|AAA80671.1\| N-(5'-phosphoribosyl)-anthranilate isomerase [Cloning vector YATAG200] gi\|1049260 - gi\|1049260\|gb\|AAA80350.1\| N-(5'phosphoribosyl)anthranilate isomerase gi\|146743447 - gi\|146743447\|gb\|ABQ43172.1\| TRP-R [Yeast expression vector pNIA-Cc] gi\|146743439 - gi\|146743439\|gb\|ABQ43166.1\| TRP1 [Yeast expression vector pNIA-Ca] Q12131 - >Q12131 (Q12131) N-(5'-phosphoribosyl)-anthranilate isomerase (TRP1P)	1.0E-67	[1..224]	[10..233]
gi\|1184825 - gi\|1184825\|gb\|AAA87582.1\| chloramphenicol resistance protein [synthetic construct]	2.0E-67	[1..224]	[10..233]
TRPF_CANGA - N-(5'-phosphoribosyl)anthranilate isomerase OS=Candida glabrata GN=TRP1 PE=3 SV=2 TRPF_CANGA - N-(5'-phosphoribosyl)anthranilate isomerase OS=Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 37...	5.0E-57	[1..224]	[1..216]
TRPF_NEIMA - N-(5'-phosphoribosyl)anthranilate isomerase OS=Neisseria meningitidis serogroup A GN=trpF PE=3 SV=1 gi\|11268653 - gi\|11268653\|pir\|\|E81935 probable phosphoribosylanthranilate isomerase (EC 5.3.1.24) NMA0890 [importe... TRPF_NEIMA - N-(5'-phosphoribosyl)anthranilate isomerase OS=Neisseria meningitidis serogroup A / serotype 4A (str...	8.0E-57	[9..224]	[1..205]
TRPF_THEMA - N-(5'-phosphoribosyl)anthranilate isomerase OS=Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3... TRPF_THEMA - N-(5'-phosphoribosyl)anthranilate isomerase OS=Thermotoga maritima GN=trpF PE=1 SV=1	9.0E-57	[12..223]	[2..203]
gi\|8569670, gi\|8... - gi\|8569670\|pdb\|1DL3\|B Chain B, Crystal Structure Of Mutually Generated Monomers Of Dimeric Phosphori...	2.0E-56	[12..223]	[2..201]

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Predicted Domain #1

Region A:
Residues: [1-224]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSVINFTGSS GPLVKVCGLQ STEAAECALD SDADLLGIIC VPNRKRTIDP VIARKISSLV  60
   61 KAYKNSSGTP KYLVGVFRNQ PKEDVLALVN DYGIDIVQLH GDESWQEYQE FLGLPVIKRL 120
  121 VFPKDCNILL SAASQKPHSF IPLFDSEAGG TGELLDWNSI SDWVGRQESP ESLHFMLAGG 180
  181 LTPENVGDAL RLNGVIGVDV SGGVETNGVK DSNKIANFVK NAKK

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	57.69897
Match:	1nsj__
Description:	N-(5'phosphoribosyl)antranilate isomerase, PRAI
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
tryptophan synthase activity	2.99898167480072	bayes_pls_golite062009
indole-3-glycerol-phosphate synthase activity	2.98379231184807	bayes_pls_golite062009
phosphoribosylanthranilate isomerase activity	2.57188946638955	bayes_pls_golite062009
catalytic activity	2.44231061702877	bayes_pls_golite062009
carbon-carbon lyase activity	1.80077901589281	bayes_pls_golite062009
carboxy-lyase activity	1.32677036501434	bayes_pls_golite062009
imidazoleglycerol-phosphate synthase activity	0.567370625225674	bayes_pls_golite062009
lyase activity	0.258652421339738	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: