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View Structure Prediction Details

Protein: HFM1
Organism: Saccharomyces cerevisiae
Length: 1046 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for HFM1.

Description E-value Query
Range
Subject
Range
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
0.0 [2..1046] [2..1046]
gi|17377416 - gi|17377416|sp|P51979|HFM1_YEAST ATP-dependent DNA helicase MER3 (HFM1 protein)
0.0 [2..1046] [142..1188]
gi|114578882, gi... - gi|114578884|ref|XP_001147672.1| PREDICTED: activating signal cointegrator 1 complex subunit 3-like ...
SNRNP200 - small nuclear ribonucleoprotein 200kDa (U5)
0.0 [1..829] [49..883]
DEXHC_ARATH - DExH-box ATP-dependent RNA helicase DExH12 OS=Arabidopsis thaliana GN=EMB1507 PE=2 SV=1
0.0 [1..829] [508..1342]

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Predicted Domain #1
Region A:
Residues: [1-190]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MQSEAFPSIY ESNENCIISS PTGSGKTVLF ELAILRLIKE TNSDTNNTKI IYIAPTKSLC  60
   61 YEMYKNWFPS FVNLSVGMLT SDTSFLETEK AKKCNIIITT PEKWDLLTRR WSDYSRLFEL 120
  121 VKLVLVDEIH TIKEKRGASL EVILTRMNTM CQNIRFVALS ATVPNIEDLA LWLKTNNELP 180
  181 ANILSFDESY 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 79.0
Match: 1hv8A_
Description: Putative DEAD box RNA helicase
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [191-381]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RQVQLTKFVY GYSFNCKNDF QKDAIYNSKL IEIIEKHADN RPVLIFCPTR ASTISTAKFL  60
   61 LNNHIFSKSK KRCNHNPSDK ILNECMQQGI AFHHAGISLE DRTAVEKEFL AGSINILCST 120
  121 STLAVGVNLP AYLVIIKGTK SWNSSEIQEY SDLDVLQMIG RAGRPQFETH GCAVIMTDSK 180
  181 MKQTYENLIH G

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 79.0
Match: 1hv8A_
Description: Putative DEAD box RNA helicase
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [382-469]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TDVLESSLHL NLIEHLAAET SLETVYSIET AVNWLRNTFF YVRFGKNPAA YQEVNRYVSF  60
   61 HSVEDSQINQ FCQYLLDTLV KVKIIDIS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 10.154902
Match: 1d9xA_
Description: Nucleotide excision repair enzyme UvrB
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [470-829]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NGEYKSTAYG NAMTRHYISF ESMKQFINAK KFLSLQGILN LLATSEEFSV MRVRHNEKKL  60
   61 FKEINLSPLL KYPFLTEKKQ SQIIDRVSQK VSLLIQYELG GLEFPSYEGA SKLHQTLVQD 120
  121 KFLVFRHCFR LLKCMVDTFI EKSDGTSLKN TLFLLRSLNG HCWENTPMVL RQLKTIGLVS 180
  181 VRRLIRHGIT NLEEMGHLSD TQIEYYLNLK IGNGIKIKND ISLLPCLNIR TKLENCKIEN 240
  241 EELWLTFKVE ISATFKSSIW HGQHLSLDIE TEKSSGELID FRRLQVNKLQ SPRGFRISAK 300
  301 ISPKLEKIEF SIHCQEIAGL GKTIVYSTDH LASQFSAKTP NIRKDLNSLE KCLFYESSSD 360
  361 

[Run NCBI BLAST on this sequence.]

Detection Method: Pfam
Confidence: 97.091515
Match: PF02889
Description: Sec63 domain

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [830-1046]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GEVGKTSRVS HKDGLEESLS SDDSILDYLN ERKKSSKAVE SAAVIHPEAH SSSHFSNGRQ  60
   61 VRSNGNYECF HSCKDKTQCR HLCCKEGIPV KYIKEKGPSS IKPVSKPDQI RQPLLAKNIN 120
  121 TTPHLEKRLN SKPKQWQEEN TDIATVHTLP SKIYNLSQQM SSMEAGEQVL KSGPENCPEI 180
  181 IPIDLESSDS YSSNTAASSI SDPNGDLDFL GSDIEFE

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle