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View Structure Prediction Details

Protein: DDM1_ARATH
Organism: Arabidopsis thaliana
Length: 764 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for DDM1_ARATH.

Description E-value Query
Range
Subject
Range
gi|33086941 - gi|33086941|gb|AAP92713.1| Swi2/Snf2-related protein DDM1; decrease in DNA methylation 1; CHR1 [Arab...
543.0 [0..1] [764..1]

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Predicted Domain #1
Region A:
Residues: [1-188]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVSLRSRKVI PASEMVSDGK TEKDASGDSP TSVLNEEENC EEKSVTVVEE EILLAKNGDS  60
   61 SLISEAMAQE EEQLLKLRED EEKANNAGSA VAPNLNETQF TKLDELLTQT QLYSEFLLEK 120
  121 MEDITINGIE SESQKAEPEK TGRGRKRKAA SQYNNTKAKR AVAAMISRSK EDGETINSDL 180
  181 TEEETVIK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 11.39794
Match: 2b2uA
Description: Tandem chromodomains of human CHD1 complexed with Histone H3 Tail containing trimethyllysine 4 and dimethylarginine 2
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription repressor activity 4.08500855631983 bayes_pls_golite062009
transcription regulator activity 3.64390820819794 bayes_pls_golite062009
chromatin binding 3.1924157640698 bayes_pls_golite062009
binding 3.06758476214113 bayes_pls_golite062009
nucleic acid binding 2.19167058827256 bayes_pls_golite062009
DNA binding 2.05514577638135 bayes_pls_golite062009
histone binding 2.00388175060339 bayes_pls_golite062009
protein binding 1.61683263008775 bayes_pls_golite062009
methylated histone residue binding 1.03331560428208 bayes_pls_golite062009
DNA-dependent ATPase activity 0.998957812785999 bayes_pls_golite062009
general transcriptional repressor activity 0.75184432495983 bayes_pls_golite062009
DNA helicase activity 0.726970683178132 bayes_pls_golite062009
ATP-dependent DNA helicase activity 0.494788451379878 bayes_pls_golite062009
transcription corepressor activity 0.294457188332415 bayes_pls_golite062009
catalytic activity 0.14067200158938 bayes_pls_golite062009
transcription activator activity 0.136090220479238 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [189-764]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LQNELCPLLT GGQLKSYQLK GVKWLISLWQ NGLNGILADQ MGLGKTIQTI GFLSHLKGNG  60
   61 LDGPYLVIAP LSTLSNWFNE IARFTPSINA IIYHGDKNQR DELRRKHMPK TVGPKFPIVI 120
  121 TSYEVAMNDA KRILRHYPWK YVVIDEGHRL KNHKCKLLRE LKHLKMDNKL LLTGTPLQNN 180
  181 LSELWSLLNF ILPDIFTSHD EFESWFDFSE KNKNEATKEE EEKRRAQVVS KLHGILRPFI 240
  241 LRRMKCDVEL SLPRKKEIIM YATMTDHQKK FQEHLVNNTL EAHLGENAIR GQGWKGKLNN 300
  301 LVIQLRKNCN HPDLLQGQID GSYLYPPVEE IVGQCGKFRL LERLLVRLFA NNHKVLIFSQ 360
  361 WTKLLDIMDY YFSEKGFEVC RIDGSVKLDE RRRQIKDFSD EKSSCSIFLL STRAGGLGIN 420
  421 LTAADTCILY DSDWNPQMDL QAMDRCHRIG QTKPVHVYRL STAQSIETRV LKRAYSKLKL 480
  481 EHVVIGQGQF HQERAKSSTP LEEEDILALL KEDETAEDKL IQTDISDADL DRLLDRSDLT 540
  541 ITAPGETQAA EAFPVKGPGW EVVLPSSGGM LSSLNS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 80.522879
Match: 1z63A
Description: Sulfolobus solfataricus SWI2/SNF2 ATPase core in complex with dsDNA
Matching Structure (courtesy of the PDB):

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