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View Structure Prediction Details

Protein: nhr-66
Organism: Caenorhabditis elegans
Length: 577 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for nhr-66.

Description E-value Query
Range
Subject
Range
gi|5702091 - gi|5702091|gb|AAD47137.1|AF061181_1 green fluorescent protein-estrogen receptor alpha fusion [Mammal...
345.0 [0..2] [573..353]

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Predicted Domain #1
Region A:
Residues: [1-103]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPSGHVTTVD QQNRQQHQQQ QRQQQQAQQQ NSMARKYSMD TIQHHTMQHP HQLQYIPNHF  60
   61 MTASTDVFAA MDMSQKQSSP PGIFKIAKNE PSSSSNSQPG TPA

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [104-191]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGDRRAVPAC AICGTDSTGI HFGVDACAAC SAFFRRTVVL NKDYSCNKGG KCTVVKDGSA  60
   61 GQKCRACRFR KCISSGMDKN SVQHRRDA

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 26.30103
Match: 2a66A
Description: Human Liver Receptor Homologue DNA-Binding Domain (hLRH-1 DBD) in Complex with dsDNA from the hCYP7A1 Promoter
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [192-577]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IGKYSAGVKR ELSPDAEFEP SAKVSTVSEP STSSGPSGGF NQNVSSPAGI PRVPSTLRTT  60
   61 QASTCMNSAC GQKSVLHELI CRQNFLTEQR QLFYAGCLGD WFRKPSSIEN QTLSELTDFS 120
  121 SCMFHLWKIE PRLAADFMNR NRYLDPLPIV EKLKIYRNFV IMRQSVEEPY LTWRHGGLEK 180
  181 RWFVMPNNTY IDFNNIAKYF ENGALKDLKL DYETTTNLFL PSFTHAMDTI GEKMKKNNIT 240
  241 ETELTILLGL VLLDPGIYGI HESTRKFLKR IRDQLIHDVY MYYEDEMSHL YDPEIRMADI 300
  301 FMLVAAIKIH SIKTSENMHM LRVFDLIPAD ACFNQMLDVE SVNVSPDGQK DSEAEQGPSP 360
  361 VSVPEAARGS YQDDDMPPVL EKNCDL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 33.522879
Match: 1z5xE
Description: hemipteran ecdysone receptor ligand-binding domain complexed with ponasterone A
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle