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View Structure Prediction Details

Protein: mbk-2
Organism: Caenorhabditis elegans
Length: 796 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for mbk-2.

Description E-value Query
Range
Subject
Range
mbk-2 - serine\/threonine kinase (2 domains) status:Confirmed UniProt:Q9XTF3 protein_id:CAB03528.1
421.0 [0..1] [796..1]

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Predicted Domain #1
Region A:
Residues: [1-150]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAALASFTRN SRSYGQQPID VTQQGQRDRS VMSLDAQGRS VSHECPTSTT LVRQLYLPQI  60
   61 PQSASFAAAP TSFSGASSSS SNHHHPVYHS QNSLPPNLLG SSQNSASSNS LVQGHRNPAL 120
  121 GSGNTLTRSY HQPSSTNSST NNLYGPLGTI 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 9.0
Match: 1f3mA
Description: pak1 autoregulatory domain
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [151-333]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SRDLKQSIRD ISPPVINSSA NPHLVNYVQT SSFDNGSYEF PSGQAQQQRR LGGSQQHLAP  60
   61 LQQTASSLYS NPQSSSSQLL GQQQAVRPNY AYQQSLPRQQ HINSHQTQAF FGTVRGPTNS 120
  121 TNIVTPLRAS KTMIDVLAPV RDTVAAQATG LPNVGTSSSN GSSNSSSGVG SGGSGSLMTQ 180
  181 SIG

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [334-721]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GPNKHLSASH STLNTASTHD MMHSKIPKSP SNESLSRSHT SSSGGSQGGH NSNSGSNSGF  60
   61 RPEDAVQTFG AKLVPFEKNE IYNYTRVFFV GSHAKKQAGV IGGANNGGYD DENGSYQLVV 120
  121 HDHIAYRYEV LKVIGKGSFG QVIKAFDHKY QQYVALKLVR NEKRFHRQAD EEIRILDHLR 180
  181 RQDSDGTHNI IHMLDYFNFR NHKCITFELL SINLYELIKR NKFQGFSLML VRKFAYSMLL 240
  241 CLDLLQKNRL IHCDLKPENV LLKQQGRSGI KVIDFGSSCF DDQRIYTYIQ SRFYRAPEVI 300
  301 LGTKYGMPID MWSLGCILAE LLTGYPLLPG EDENDQLALI IELLGMPPPK SLETAKRART 360
  361 FITSKGYPRY CTATSMPDGS VVLAGARS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 42.09691
Match: 2ozoA
Description: No description for 2ozoA was found.

Predicted Domain #4
Region A:
Residues: [722-796]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KRGKMRGPPA SRSWSTALKN MGDELFVDFL KRCLDWDPET RMTPAQALKH KWLRRRLPNP  60
   61 PRDGLESMGG LADHE

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 64.154902
Match: 1z57A
Description: Crystal structure of human CLK1 in complex with 10Z-Hymenialdisine
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle