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View Structure Prediction Details

Protein: trt-1
Organism: Caenorhabditis elegans
Length: 561 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for trt-1.

Description E-value Query
Range
Subject
Range
gi|74422303 - gi|74422303|gb|ABA06434.1| telomerase reverse transcriptase [Caenorhabditis remanei]
272.0 [0..8] [558..18]

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Predicted Domain #1
Region A:
Residues: [1-209]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAPTIKSSLT TLHEEIRKYD KRRHWNTIIR KSAHLSLVRN IFKKKRRQKL NYRHMSTFLA  60
   61 SSENISNIRD TVVLLEINKL SQSILSSRNI FELRKLKPTR KMVEIEHCFV SKNDTFVACS 120
  121 KLISMFHLEK YIGSTNCANI LEWITKMLNN GGYHKMKPFV YKEAPFTRAF RASKVMKNVD 180
  181 PNVKRNIQTS IVNNLKSGVH WWALMALRQ

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [210-274]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VMIPIVIKEE RVLLWRDGYL NILTKEIKDF KQRYIVQKAP HFIRPNVATF KLSISRQKLR  60
   61 PLFKR

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [275-561]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KAIDKKTETM QWKRLNSMLS WCLERSGVYR HTIRDSCKKV SDFLKKNSQN SKIIGYTADV  60
   61 SKCFSTVNHD VLISIIDRLF SQEHDIYTVC GKGRNHGGFH KLIFCSAGTE LNAHEALRRK 120
  121 MELKGVFNFE VCYREMSSST TLYSVIRTTL STYYYKRGPT SWRITKGVPQ GHPISSNLAH 180
  181 MYLNNFEQKY WSNEKEDSRI VFCRYEDDFI FITTENSLFE KMMKPLSTGN NTHFLTANPK 240
  241 KFKKSERCGA SQVLQWCGVK LDFQSGNCFI RRRCKDGVAR QFLIKLQ

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 12.045757
Match: 1rw3A
Description: The crystal structure of the monomeric reverse transcriptase from Moloney murine leukemia virus
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
catalytic activity 0.518931870161593 bayes_pls_golite062009
transferase activity 0.35636561630516 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 0.32441153240842 bayes_pls_golite062009
nucleotidyltransferase activity 0.29860211454192 bayes_pls_golite062009
DNA polymerase activity 0.0603497936698201 bayes_pls_golite062009
DNA-directed DNA polymerase activity 0.0602875211585996 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle