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View Structure Prediction Details

Protein: nhr-25
Organism: Caenorhabditis elegans
Length: 572 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for nhr-25.

Description E-value Query
Range
Subject
Range
gi|7677116 - gi|7677116|gb|AAF67038.1|AF179214_1 NHR-25 alpha [Caenorhabditis elegans]
266.0 [0..7] [572..3]

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Predicted Domain #1
Region A:
Residues: [1-163]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTDVERMVLR PNHEGEMCPV CGDRVSGYHY GLLTCESCKG FFKRTVQNKK QYQCSAEANC  60
   61 HVDRTCRKRC PSCRFQKCLT MGMKMEAVRA DRMRGGRNKF GSFYKKDRAH RMQRNAMRVS 120
  121 TVQVPAVLGA QSQAQTFYQP PEHQVSSSTT DQNNQINYFD QTK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 25.39794
Match: 2a66A
Description: Human Liver Receptor Homologue DNA-Binding Domain (hLRH-1 DBD) in Complex with dsDNA from the hCYP7A1 Promoter
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [164-230]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IKTEYIKTEY DAHLQSPTLS SSTNQQLSVS DFIMRPGYLV DPQDSLAVLL GSTIDDPLLR  60
   61 HTFPAAY

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [231-572]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QLNEVKQEPF DYSEQFIHHS LHDYPTYTSN TTNYATMMPM TTVSSTQSLV TSTSSTTTGR  60
   61 MTEASSTSPI LPLCPAPTEK TVDHFYNSSI AEMCKTLPDD AQIARIFTSV KGTSKPEKHA 120
  121 FSIQVAEENL KDIVIWAKND QLFSKLSLDD QMILLQTSWT TVHIVDITNA MVHGNLLSQY 180
  181 KMSNGDEVPV GLVALLGNQT FVSSWNDVVI RLRNMGFTNF DYCAFRFLAL FDQSMDSFPA 240
  241 VSTARSRVLQ SWREVRCTTA FLEIFEQIRR LAYDSLRYLW NLHSNCPTNW EQFFPEASLV 300
  301 LEMIRTTVNR SASSSVTAIT QVPAIQLPTP QATYTAVPYM AS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 30.69897
Match: 1z5xE
Description: hemipteran ecdysone receptor ligand-binding domain complexed with ponasterone A
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle