YRC Public Data Repository - Protein Structure Prediction

Protein:	SPAC57A7.07c
Organism:	Schizosaccharomyces pombe
Length:	308 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SPAC57A7.07c.

Description	E-value	Query Range	Subject Range
gi\|84394376, gi\|... - gi\|84394376\|ref\|ZP_00993096.1\| 5-methyltetrahydrofolate--homocysteine methyltransferase [Vibrio sple...	332.0	[0..1]	[307..17]
gi\|88713214, gi\|... - gi\|88713214\|ref\|ZP_01107298.1\| 5-methyltetrahydrofolate--homocysteine methyltransferase [Flavobacter...	332.0	[0..1]	[308..12]
METH_VIBPA - Methionine synthase OS=Vibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633) GN=metH PE=3 SV=... gi\|153840028, gi... - gi\|153840028\|ref\|ZP_01992695.1\| methionine synthase [Vibrio parahaemolyticus AQ3810], gi\|149746415\|g... METH_VIBPA - Methionine synthase OS=Vibrio parahaemolyticus GN=metH PE=3 SV=1	332.0	[0..1]	[307..17]
gi\|28279621, gi\|... - gi\|37620202\|ref\|NP_932338.1\| 5-methyltetrahydrofolate-homocysteine methyltransferase [Danio rerio], ...	330.0	[0..1]	[308..28]
gi\|120557905, gi... - gi\|82741988\|ref\|ZP_00904695.1\| 5-methyltetrahydrofolate--homocysteine methyltransferase [Shewanella ...	330.0	[0..1]	[307..23]
gi\|90435681, gi\|... - gi\|90588039\|ref\|ZP_01243691.1\| Homocysteine S-methyltransferase [Flavobacterium johnsoniae UW101], g...	330.0	[0..1]	[308..13]
METH_ALIFS - Methionine synthase OS=Aliivibrio fischeri GN=metH PE=3 SV=1	330.0	[0..1]	[304..18]
gi\|58198673\|gb\|A... - B12-dependent homocysteine-N5-methyltetrahydrofolate transmethylase [Escherichia blattae] gi\|58198673 - gi\|58198673\|gb\|AAW65980.1\| B12-dependent homocysteine-N5-methyltetrahydrofolate transmethylase [Esch...	330.0	[0..1]	[307..16]
gi\|67155919 - gi\|67155919\|ref\|ZP_00417546.1\| Dihydropteroate synthase, DHPS:Homocysteine S-methyltransferase:Cobal... gi\|67086863, gi\|... - gi\|67155919\|ref\|ZP_00417546.1\| Dihydropteroate synthase, DHPS:Homocysteine S-methyltransferase:Cobal...	329.0	[0..1]	[307..64]
gi\|30138951, gi\|... - gi\|30249588\|ref\|NP_841658.1\| B12-dependent methionine synthase [Nitrosomonas europaea ATCC 19718], g...	329.0	[0..1]	[308..18]

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Predicted Domain #1

Region A:
Residues: [1-308]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLMLDGGSTA ILPKLPESIS ESRLWTSEAL VRYPEIVVKH HEEFLKVCDI ISTFTYQLDA  60
   61 SIYDEKVEGV PLKQVYANSI GLPVYAREHL GLPNKYIALC LGSHAATIPG CMEYKMIYDK 120
  121 PTDFEMLYNF HKNRIEAIQA SNPKAFEKID FIAFESLPHV TEAEVVCQLI QDMKGWSKRC 180
  181 WITCTCPERS TIERVSSIIS KILSINHDSI WGIGVNCFHL SLLEPIAKML SSLLPSNITA 240
  241 ILYPDGRGLY QNPDGTFSPG STDHPAPSPE EWSTITAKYS NLHNGNLILG GCCETNYNHL 300
  301 SLLREKTK

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	71.045757
Match:	1q7mA
Description:	Cobalamin-dependent methionine synthase (MetH) from Thermotoga maritima (Oxidized, Monoclinic)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
S-methyltransferase activity	3.53817178180686	bayes_pls_golite062009
homocysteine S-methyltransferase activity	2.53321380120921	bayes_pls_golite062009
catalytic activity	1.41033217274476	bayes_pls_golite062009
transferase activity	0.499011632852061	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: