YRC Public Data Repository - Protein Structure Prediction

Protein:	SPCC1739.06c
Organism:	Schizosaccharomyces pombe
Length:	496 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SPCC1739.06c.

Description	E-value	Query Range	Subject Range
gi\|30248547, gi\|... - gi\|30248547\|ref\|NP_840617.1\| cysG_2; uroporphyrinogen-III methylase [Nitrosomonas europaea ATCC 1971...	422.0	[0..1]	[496..30]
CYSG_PSEF5 - Siroheme synthase OS=Pseudomonas fluorescens (strain Pf-5 / ATCC BAA-477) GN=cysG PE=3 SV=1	411.0	[0..1]	[496..4]
CYSG_PSEU2 - Siroheme synthase OS=Pseudomonas syringae pv. syringae (strain B728a) GN=cysG PE=3 SV=1	409.0	[0..1]	[496..4]
CYSG_PSE14 - Siroheme synthase OS=Pseudomonas savastanoi pv. phaseolicola (strain 1448A / Race 6) GN=cysG PE=3 SV...	408.0	[0..1]	[496..4]
CYSG2_YERPS - Siroheme synthase 2 OS=Yersinia pseudotuberculosis GN=cysG2 PE=3 SV=1 CYSG2_YERPS - Siroheme synthase 2 OS=Yersinia pseudotuberculosis serotype I (strain IP32953) GN=cysG2 PE=3 SV=1 gi\|170022493, gi... - gi\|170022493\|ref\|YP_001718998.1\| siroheme synthase [Yersinia pseudotuberculosis YPIII], gi\|169749027... CYSG2_YERP3 - Siroheme synthase 2 OS=Yersinia pseudotuberculosis serotype O:1b (strain IP 31758) GN=cysG2 PE=3 SV=...	408.0	[0..2]	[495..5]
CYSG_NITEC - Siroheme synthase OS=Nitrosomonas eutropha (strain C91) GN=cysG PE=3 SV=1	407.0	[0..2]	[496..5]
CYSG_PSESM - Siroheme synthase OS=Pseudomonas syringae pv. tomato GN=cysG PE=3 SV=1 CYSG_PSESM - Siroheme synthase OS=Pseudomonas syringae pv. tomato (strain DC3000) GN=cysG PE=3 SV=1 gi\|213925160, gi... - gi\|213970056\|ref\|ZP_03398188.1\| siroheme synthase [Pseudomonas syringae pv. tomato T1], gi\|213925160...	405.0	[0..1]	[496..4]
CYSG_PSEHT - Siroheme synthase OS=Pseudoalteromonas haloplanktis (strain TAC 125) GN=cysG PE=3 SV=1	405.0	[0..1]	[495..4]
CYSG_PSEPF - Siroheme synthase OS=Pseudomonas fluorescens (strain Pf0-1) GN=cysG PE=3 SV=1	404.0	[0..1]	[496..4]
gi\|229706429, gi... - gi\|229836361\|ref\|ZP_04456528.1\| siroheme synthase / precorrin-2 oxidase /sirohydrochlorin ferrochela... gi\|21960942, gi\|... - gi\|22127811\|ref\|NP_671234.1\| uroporphyrinogen III methylase [Yersinia pestis KIM], gi\|21960942\|gb\|AA...	404.0	[0..2]	[495..17]

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Predicted Domain #1

Region A:
Residues: [1-496]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MIVSWSLKDA VVVVVGSGKN AYRRVNLCLS ENSSKIFWFC RSSADGGFDV GHLQLDAKKS  60
   61 DAIEILPISE FDPVRSLTTL GKEETDFLVD AVFVSESNHH EKEILHRTCK RYRIPLNIID 120
  121 NPSLCSFTLP ATWSEPPLQI SLSTSSNGCR LAQRLLRHVV SSLPSGMPEA IERFGRVRAI 180
  181 TKTPEKKQWI NHVSDFWPLE KLVRMTEDDL LAIVSDNFSL PLSSSQSSSL ANSYESLSTT 240
  241 LDKPSLTLDP EAFPTHKRGS IALIGSGPGS PDLLTVAARK AIMKADYVLA DKLVPEAVLQ 300
  301 LIPRHTPLFI ARKFPGNADK AQDELHQVAF DALSRGDYVV RLKQGDPYIY GRGGEEYLFF 360
  361 TQHGYVPTVI PGISSALMAP ISAGIPVTHR GVADQFLVCT GTGQKGSMPK IPSFVPTQTT 420
  421 VFLMALHRLE ILVQALIESG WPRVLPVCIA ERVSCPDQRF IFSTLEDVVE EYNKYESLPP 480
  481 GLLITGYSCN TLRNTA

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	109.0
Match:	1pjqA
Description:	Structure and function of CysG, the multifunctional methyltransferase/dehydrogenase/ferrochelatase for siroheme synthesis
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
uroporphyrin-III C-methyltransferase activity	3.573271502205	bayes_pls_golite062009
C-methyltransferase activity	3.35393353163232	bayes_pls_golite062009
precorrin-2 dehydrogenase activity	2.63318043162058	bayes_pls_golite062009
precorrin-4 C11-methyltransferase activity	2.18371138649366	bayes_pls_golite062009
catalytic activity	1.48349578618275	bayes_pls_golite062009
transferase activity	0.912524944496351	bayes_pls_golite062009
transferase activity, transferring one-carbon groups	0.463693177369635	bayes_pls_golite062009
methyltransferase activity	0.454156823400351	bayes_pls_golite062009
oxidoreductase activity, acting on CH-OH group of donors	0.418775403210681	bayes_pls_golite062009
S-adenosylmethionine-dependent methyltransferase activity	0.323461631906645	bayes_pls_golite062009
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	0.32207755075663	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: