YRC Public Data Repository - Protein Structure Prediction

Protein:	mts4
Organism:	Schizosaccharomyces pombe
Length:	891 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for mts4.

Description	E-value	Query Range	Subject Range
gi\|76607529 - gi\|76607529\|ref\|XP_589444.2\| PREDICTED: similar to proteasome 26S non-ATPase subunit 2 [Bos taurus]	797.0	[0..1]	[886..129]
gi\|114590784 - gi\|114590784\|ref\|XP_001147528.1\| PREDICTED: proteasome 26S non-ATPase subunit 2 isoform 3 [Pan trogl...	793.0	[0..1]	[886..91]
gi\|74003415 - gi\|74003415\|ref\|XP_535824.2\| PREDICTED: similar to proteasome 26S non-ATPase subunit 2 [Canis famili...	789.0	[0..1]	[886..83]
gi\|114590788 - gi\|114590788\|ref\|XP_516913.2\| PREDICTED: proteasome 26S non-ATPase subunit 2 isoform 4 [Pan troglody... PSD2, PSMD2 - proteasome (prosome, macropain) 26S subunit, non-ATPase, 2, pleckstrin and Sec7 domain containing 2	784.0	[0..1]	[886..11]
gi\|60653295, gi\|... - gi\|60653297\|gb\|AAX29343.1\| proteasome 26S subunit 2 [synthetic construct], gi\|60653295\|gb\|AAX29342.1...	783.0	[0..1]	[886..11]
gi\|74198664 - gi\|74198664\|dbj\|BAE39806.1\| unnamed protein product [Mus musculus]	781.0	[0..1]	[886..11]

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Predicted Domain #1

Region A:
Residues: [1-200]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSKDISSKS PSGNDALNDK KGTKTSETND RNSTNNTKER DELEDLSEED LQLKNDLELL  60
   61 VQAVQDATPE LVGSSLTQLK EIIRTSTSSM TAVPKPLKFL RPHYFTLVKI YDSWPQSPQK 120
  121 TQLADILSVL GMSYSNTSKH ESLKYRLQGV TTDPSLWGHE YVRHLASEIE EEFASRQEEE 180
  181 APTDDLMELA LTIVPFFLTH

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	5.39794
Match:	1pwuA
Description:	Crystal Structure of Anthrax Lethal Factor complexed with (3-(N-hydroxycarboxamido)-2-isobutylpropanoyl-Trp-methylamide), a known small molecule inhibitor of matrix metalloproteases.
Matching Structure (courtesy of the PDB):

Predicted Domain #2

Region A:
Residues: [201-716]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NAEADAIDLL QELGAIEKVV PFVELDNASR VCLYITSCVN LLPFPEDVAM LRTAHAIYRK  60
   61 FDQLTQALNV AIRLDDMSLI KEDCEAATDP LLKKQMSYML ARQQIPMDMG DEELNDALNN 120
  121 THLSDHFHYL GKELNLMDPK VPEDIFKTHL EVARTGLGAS GVYSAKQNLA NTFVNALVNA 180
  181 GYSNDRLILV DDEKTSWIYK NKESGLISAT ASIGLLQLWN VDMGLSLLDK YLYSSEENTK 240
  241 AGALLGIGVT NVAVRNEADP AMAILSEYLE TGSVKLRASA ILGLGLAYSG ANREDLLDML 300
  301 SPIVTDTDCP MQLSCLAALS LGLIFVGTCN GDVASTILQT LMEREESAQN DQWGRFMALG 360
  361 LALLFNGKQD LADATVETLK AIEGKIARQA EILVDICSYA GTGNVLHIQK LLHICSEPPS 420
  421 DDAKESETTI QTFAALGVAT IAMGEDIGAE MVLRHFDHMM HYGEPSIRKA IPLALGLLSA 480
  481 SNPQMRIFDT LSRYSHDNDL DVAYNAIFAM GLVGAG

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	59.39794
Match:	2pkgA
Description:	No description for 2pkgA was found.

Predicted Domain #3

Region A:
Residues: [717-785]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TSNARLAQLL RQLASYYHKE SNALFMVRIA QGLLYLGKGT MTLNPYHTER QILGQTAFAG  60
   61 LMTVVLAML

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	20.0
Match:	1q1sC
Description:	Mouse Importin alpha- phosphorylated SV40 CN peptide complex
Matching Structure (courtesy of the PDB):

Predicted Domain #4

Region A:
Residues: [786-891]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DANTFVLDTS HWLLYAITLA IRPRMLITLG EDGQYLPVSV RVGQAVDVVG QAGRPKVITG  60
   61 WVTHTTPVLL HHNERAELAT EAYTPLTSLE GIVILKKNTE DIEMTA

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits