YRC Public Data Repository - Protein Structure Prediction

Protein:	hmg1
Organism:	Schizosaccharomyces pombe
Length:	1053 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for hmg1.

Description	E-value	Query Range	Subject Range
gi\|1374961, gi\|7... - pir\|\|S72194 hydroxymethylglutaryl-CoA reductase (EC 1.1.1.88) - fission yeast (Schizosaccharomyces p...	982.0	[0..1]	[1053..1]
gi\|42554194, gi\|... - gi\|46134115\|ref\|XP_389373.1\| hypothetical protein FG09197.1 [Gibberella zeae PH-1], gi\|42554194\|gb\|E...	838.0	[0..2]	[1044..36]
gi\|49092986, gi\|... - gi\|67526719\|ref\|XP_661421.1\| hypothetical protein AN3817.2 [Aspergillus nidulans FGSC A4], ref\|XP_40...	818.0	[0..2]	[1049..34]
gi\|85113573 - gi\|85113573\|ref\|XP_964546.1\| 3-hydroxy-3-methylglutaryl-coenzyme A reductase [Neurospora crassa OR74... gi\|28926332, gi\|... - gi\|32408825\|ref\|XP_324892.1\| hypothetical protein [Neurospora crassa], gi\|28926332\|gb\|EAA35310.1\| 3-...	808.0	[0..2]	[1028..37]
HMG1 - One of two isozymes of HMG-CoA reductase that catalyzes the conversion of HMG-CoA to mevalonate, whi... HMDH1_YEAST - 3-hydroxy-3-methylglutaryl-coenzyme A reductase 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / ...	808.0	[0..2]	[1024..18]
gi\|119188881, gi... - gi\|90303833\|gb\|EAS33464.1\| hypothetical protein CIMG_04488 [Coccidioides immitis RS], gi\|119188881\|r...	803.0	[0..1]	[1034..35]
HMDH_RABIT - 3-hydroxy-3-methylglutaryl-coenzyme A reductase OS=Oryctolagus cuniculus GN=HMGCR PE=3 SV=1	801.0	[0..198]	[1039..55]
gi\|76626437 - gi\|76626437\|ref\|XP_605365.2\| PREDICTED: similar to 3-hydroxy-3-methylglutaryl-coenzyme A reductase (...	799.0	[0..198]	[1039..145]
gi\|60688087 - gi\|60688087\|gb\|AAH91631.1\| Unknown (protein for IMAGE:7197923) [Xenopus laevis]	799.0	[0..198]	[1039..49]
HMGCR - 3-hydroxy-3-methylglutaryl-CoA reductase	799.0	[0..198]	[1038..55]

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Predicted Domain #1

Region A:
Residues: [1-528]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MIYKLAARYP IQVIAIVGIL VSMAYFSFLE ALTQEDFPVL IRALKRFGIL DGFPNTRLPN  60
   61 EMILKLSSVQ GEDASVWEQI PAAELGGEGF VDFDITQWYY PANAKVDVAQ LVEPYRNDCI 120
  121 FHDASGACHF FFKEVGNWTV SSIALPSNLA NPPIDYFLDS SSTVIQRILP AIREHGISWS 180
  181 WLLQLIARTW MNTLKIASQA SKTELLIVGT AYACMLISIV SLYLKMRRLG SKFWLFFSVL 240
  241 LSTLFSVQFA MTLVRASGVR ISLVSLIESL PFLINVVALD KAAELTRQVI TRCSVSDSHS 300
  301 PMHEDIAKAC RNAAPPILRH FSFGIVVLAI FSYCNFGIKQ FFLFAAVMIY DLLLLFSFFV 360
  361 AILTLKLEMR RYNAKDDVRK VLIEEGLSES TARHVADGND SSATTSAGSR YFKVRYGTKI 420
  421 ILFIFIAFNL FELCSIPFKH YAATSAAAAR LIPLVRSQYP DFKSQRLLDD GVFDDVLSAI 480
  481 SSMSNIESPS VRLLPAVFYG AELSSTSFLS TIHSFINNWS HYISASFL

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	64.154902
Match:	1oy6A
Description:	Multidrug efflux transporter AcrB pore domain; PN1, PN2, PC1 and PC2 subdomains; Multidrug efflux transporter AcrB TolC docking domain; DN and DC subdomains; Multidrug efflux transporter AcrB transmembrane domain
Matching Structure (courtesy of the PDB):

Predicted Domain #2

Region A:
Residues: [529-1053]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SKWIVCALSL SIAVNVFLLN AARLNSIKEE PEKKVVEKVV EVVKYIPSSN SSSIDDIQKD  60
   61 EIAQESVVRS LEECITLYNN GQISTLNDEE VVQLTLAKKI PLYALERVLK DVTRAVVIRR 120
  121 TVVSRSSRTK TLESSNCPVY HYDYSRVLNA CCENVIGYMP LPLGVAGPLI IDGKPFYIPM 180
  181 ATTEGALVAS TMRGCKAINA GGGAVTVLTR DQMSRGPCVA FPNLTRAGRA KIWLDSPEGQ 240
  241 EVMKKAFNST SRFARLQHIK TALAGTRLFI RFCTSTGDAM GMNMISKGVE HALVVMSNDA 300
  301 GFDDMQVISV SGNYCTDKKP AAINWIDGRG KSVIAEAIIP GDAVKSVLKT TVEDLVKLNV 360
  361 DKNLIGSAMA GSVGGFNAHA ANIVTAVYLA TGQDPAQNVE SSNCITLMDN VDGNLQLSVS 420
  421 MPSIEVGTIG GGTVLEPQGA MLDLLGVRGA HMTSPGDNSR QLARVVAAAV MAGELSLCSA 480
  481 LASGHLVKSH IGLNRSALNT PAMDSSAKKP ATDALKSVNS RVPGR

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	1000.0
Match:	1dq8A
Description:	NAD-binding domain of HMG-CoA reductase; Substrate-binding domain of HMG-CoA reductase
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits