YRC Public Data Repository - Protein Structure Prediction

Protein:	gpi8
Organism:	Schizosaccharomyces pombe
Length:	380 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gpi8.

Description	E-value	Query Range	Subject Range
GPI8_PONPY - GPI-anchor transamidase precursor - Pongo pygmaeus (Orangutan) GPI8_PONAB - GPI-anchor transamidase OS=Pongo abelii GN=PIGK PE=2 SV=1	498.0	[0..4]	[380..12]
gi\|114557239 - gi\|114557239\|ref\|XP_001168438.1\| PREDICTED: phosphatidylinositol glycan anchor biosynthesis, class K... sp\|Q92643\|GPI8_H... - GPI-anchor transamidase OS=Homo sapiens GN=PIGK PE=1 SV=2 VAR_051518, GPI-anchor transamidase OS=Hom...	498.0	[0..4]	[380..12]
PIGK - phosphatidylinositol glycan anchor biosynthesis, class K	497.0	[0..4]	[380..12]
gi\|73959812 - gi\|73959812\|ref\|XP_853775.1\| PREDICTED: similar to GPI-anchor transamidase precursor (GPI transamida...	496.0	[0..4]	[380..13]
gi\|109008530 - gi\|109008530\|ref\|XP_001102474.1\| PREDICTED: phosphatidylinositol glycan, class K [Macaca mulatta]	494.0	[0..20]	[380..39]
gi\|54035423, gi\|... - gi\|58865476\|ref\|NP_001011953.1\| phosphatidylinositol glycan anchor biosynthesis, class K [Rattus nor...	494.0	[0..3]	[380..11]
GPI8_PIG - GPI-anchor transamidase OS=Sus scrofa GN=PIGK PE=2 SV=1	491.0	[0..1]	[380..17]

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Predicted Domain #1

Region A:
Residues: [1-305]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MIVQFVALLL LNLLQIIAAE SSHTNNWAVL ISTSRFWFNY RHTANVLGIY RSVKRLGIPD  60
   61 SQIILMIADD YACNSRNLFP GTVFDNADRA LDLYGEEIEI DYKGYEVTVE AFIRLLTERV 120
  121 PENTPASKRL LTNERSNILI YMTGHGGDGF IKFQDAEELS SEDLADAIEQ IHQHKRYNEI 180
  181 LFMVDTCQAN SLYTKIYSPN VLAIGSSEVG TSSYSHHADI DIGVAVIDRF TFSNLEFLEN 240
  241 RVDSKSKLTM QDLINSYNPY EIHSTPGVQP INLRRSPDDI LITDFFGNVR DIELHSEKIN 300
  301 WMLPG

[Run NCBI BLAST on this sequence.]

Detection Method:	FFAS03
Confidence:	2.11
Match:	1i4eB
Description:	Caspase-8
Matching Structure (courtesy of the PDB):

Predicted Domain #2

Region A:
Residues: [306-380]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ENTTKPSIKR NSFVFQAQND MQDDGKGFGI SNLKSFLPPT RELKYKKHPI SRIISAVVCI  60
   61 SFSIGFPYYA SKYLK

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

		MCM Score	GO Score	GO Term	SCOP Match	SCOP Description
View	Download	0.483	0.672	cysteine-type endopeptidase activity	a.39.1	EF-hand
View	Download	0.500	0.003	cysteine-type endopeptidase activity	a.27.1	Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
View	Download	0.621	0.001	cysteine-type endopeptidase activity	a.130.1	Chorismate mutase II
View	Download	0.583	0.000	cysteine-type endopeptidase activity	a.46.1	Methionine synthase domain
View	Download	0.444	N/A	N/A	a.39.1	EF-hand

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits