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View Structure Prediction Details

Protein: Med-PB
Organism: Drosophila melanogaster
Length: 697 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for Med-PB.

Description E-value Query
Range
Subject
Range
gi|3599950 - gi|3599950|gb|AAC35436.1| Medea-B [Drosophila melanogaster]
520.0 [0..1] [697..1]

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Predicted Domain #1
Region A:
Residues: [1-166]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGGGSGACPP AHMYGAVAPQ DIIVRDMVQM PPPPSNAPTS ADACLSIVHS LMCHRQGGES  60
   61 EGFAKRAIES LVKKLKEKRD ELDSLITAIT TNGAHPSKCV TIQRTLDGRL QVAGRKGFPH 120
  121 VIYARIWRWP DLHKNELKHV KYCAFAFDLK CDSVCVNPYH YERVVS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 47.045757
Match: 1mhdA
Description: SMAD MH1 domain
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [167-399]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PGIDLSGLSL QSGPSRLVKD EYSAGPLVGS MDIDGNDIGT IQHHPTQMVG PGGYGYPQGP  60
   61 SEYAVPHGMP GMPGPMNPGP VMAPPPPPQQ AQNPQGNGVH HTQANSPTDP ASALAMQQQQ 120
  121 QQQQQQQQQQ QQQQQQSGGV PNGSVNAGGG AAAGGQYYGQ PPPVSQMQGA GGGGTSVAPS 180
  181 VHAQQNGYVS QPGSAGSAPV GGGGVFGTAQ PTPQQPQQPP TGVQANTGSA GAQ

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 5.0
Match: 1m2vB
Description: Sec24
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [400-456]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AGAGGGAAGT WTGPNTLTYT QSMQPPDPRS LPGGFWNSSL SGDLGSPQQT PPQQQQQ

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [457-697]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QQQPRLLSRQ PPPEYWCSIA YFELDTQVGE TFKVPSAKPN VIIDGYVDPS GGNRFCLGAL  60
   61 SNVHRTEQSE RARLHIGKGV QLDLRGEGDV WLRCLSDNSV FVQSYYLDRE AGRTPGDAVH 120
  121 KIYPAACIKV FDLRQCHQQM HSLATNAQAA AAAQAAAVAG VANQQMGGGG RSMTAAAGIG 180
  181 VDDLRRLCIL RLSFVKGWGP DYPRQSIKET PCWIEVHLHR ALQLLDEVLH AMPIDGPRAA 240
  241 A

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 83.522879
Match: 1ygsA
Description: CRYSTAL STRUCTURE OF THE SMAD4 TUMOR SUPPRESSOR C-TERMINAL DOMAIN
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle