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View Structure Prediction Details

Protein: MED25-PA
Organism: Drosophila melanogaster
Length: 863 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for MED25-PA.

Description E-value Query
Range
Subject
Range
MED25_XENLA - Mediator of RNA polymerase II transcription subunit 25 OS=Xenopus laevis GN=med25 PE=2 SV=1
302.0 [0..8] [776..11]

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Predicted Domain #1
Region A:
Residues: [1-245]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEVDQIPLAD VVFVIEGSAI NGAYINELKT NYILPTLEHF TTGSIDEREY LIAERFATLY  60
   61 GIVVYRTAAN LLEPVCSTYG PFLQPQKVME TIERLPLVGG GMESCAHMAE GFAAAHGCFD 120
  121 DISERRQLLD QTSVQRHCIL ICNSPPYQMP TTESWKYPGK SCEQLAALFN ERKINLSIIA 180
  181 PRKMPVLFKL FMKADGDQPI TSKNYAKNIR HLVLLKGYSL KERAPSPNSM AAQMAAPNAA 240
  241 QATVQ

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 1.02
Match: 2iueA
Description: No description for 2iueA was found.

Predicted Domain #2
Region A:
Residues: [246-402]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QQQQQQQNQA GQQQQGQGMP MDTTPAQQQQ QQQQQQQQQQ QQGNPQQQVM NMNTMQQQQP  60
   61 GPNPPAGLLN PQQQQQLLQQ QQQNQFVSNQ MQNQNFQQNV GPGQNRWMYP NQPGQARPPF 120
  121 MQGAGNVGGV GQGGGMQQNP NSALISRINA PPPNQTV

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [403-564]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TSLQQQQQQQ AQQQQQQQQQ AQQQQQQRMQ MLSQQQMLNH QQLQQQQQLA QQQQQQQQGQ  60
   61 QQQQVNPNAG NNMMPASNAG NMSNPQQQQQ QVGQQSNPQQ QGNPQQQQQG NSQQEQASLR 120
  121 EKIWTGVLEW SEKPKSDQQK IPHTLQCTVC TNIKDGEPEI KA

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [565-786]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ENWPPKLLMQ LMPKHLVGNI GGQFLKDSKM VVFRPTPGEA LDSLAKMMTS GYAGCVHFSS  60
   61 IPNSPACDLK VLILLYTPDR NAFLGFIPNN QAMFVERLRK VIQQKQHGNM QQQQQQQQMM 120
  121 QQQGKSPMEL QQQQQQQQQQ QQMQQDNSQQ QHYNQFQLNM QMGGGGPGGG PGPGPGGMPM 180
  181 QQNQMQMNMM QQQRMPLGVG VGVGVGPGGV PNPNLQQQLQ QV

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 5.0
Match: 1m2vB
Description: Sec24
Matching Structure (courtesy of the PDB):

Predicted Domain #5
Region A:
Residues: [787-863]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 APNVAAMQQQ QAQQQQQRMV RPMMSNNNPG LRQLLQHQTT PGNQFRPQMG GQNPNQMGAG  60
   61 GPMVGNRNFD DGNYEFM

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


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