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View Structure Prediction Details

Protein: CG5214-PA
Organism: Drosophila melanogaster
Length: 468 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CG5214-PA.

Description E-value Query
Range
Subject
Range
gi|84667992, gi|... - gi|84684239|ref|ZP_01012141.1| Dihydrolipoamide transsuccinylase [Rhodobacterales bacterium HTCC2654...
425.0 [0..3] [468..47]

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Predicted Domain #1
Region A:
Residues: [1-73]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTGIISIVTR RLPQTLGMRA LRSNEVKRCI RQYSRLVACA AQQQQLLRQD GSNRCQEATR  60
   61 LLTWQGIHTT SSL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 13.30103
Match: 2qf7A
Description: No description for 2qf7A was found.

Predicted Domain #2
Region A:
Residues: [74-235]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 WSEQTVNVPP FADSIAEGDI KFTCKVGDSF AADEAVMEIE TDKTTVAVPA PFSGTLTDIL  60
   61 VKDGDTVKPG QALFKIKPGA APAKAAAPAA APAPAAPKAA PAPAAAPKPA PPPPAAGAPK 120
  121 PPPPPPPKAA PRPPPPAPVA ALKPAVAQVK VPPADGSRQI LG

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 19.09691
Match: 1zy8K
Description: The crystal structure of dihydrolipoamide dehydrogenase and dihydrolipoamide dehydrogenase-binding protein (didomain) subcomplex of human pyruvate dehydrogenase complex.
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [236-468]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TRSEQRVKMN RMRLKIAARL KDAQNTCAML TTFNEVDMSY AMDFRKQNLD AFTKKYGIKF  60
   61 GFMSIFAKAS AYALQDQPVV NAVIDGTDIV YRDYVDISVA VATPRGLVVP VIRNVEGMNY 120
  121 ADIEIALAGL ADKARRDAIT VEDMDGGTFT ISNGGVFGSL MGTPIINPPQ SAILGMHGIF 180
  181 ERPIAVKGEV KIRPMMYIAL TYDHRIIDGR EAVLFLRKIK AAVENPAIIV AGL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 89.522879
Match: 1c4tA
Description: Dihydrolipoamide succinyltransferase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
catalytic activity 0.985567717478902 bayes_pls_golite062009
transferase activity 0.65532722795675 bayes_pls_golite062009
transferase activity, transferring acyl groups 0.590907147191141 bayes_pls_golite062009
transferase activity, transferring acyl groups other than amino-acyl groups 0.589573845516701 bayes_pls_golite062009
acyltransferase activity 0.58932324215015 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle