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View Structure Prediction Details

Protein: Pak-PC, Pak-PA, ...
Organism: Drosophila melanogaster
Length: 704 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for Pak-PC, Pak-PA, ....

Description E-value Query
Range
Subject
Range
gi|1335890 - gi|1335890|gb|AAC47094.1| serine/threonine kinase PAK homolog DPAK
501.0 [0..1] [704..1]

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Predicted Domain #1
Region A:
Residues: [1-146]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSEEDKPPA PPVRLTSNRG GNERSGGGVG VGGGGLGGGG MGDVPPDMRP LPKEPDDSDR  60
   61 KKKTLKSKIK GSKPSHTDSK PNISYPTNFE HTVHVGFDAV TGEFTGMPEA WARLLMNSNI 120
  121 SKQEQKKNPQ AVLDVLKWFD NTTKQR

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 21.0
Match: 1f3mA
Description: pak1 autoregulatory domain
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [147-275]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PSSKYMTNAI TTHSGSSLSR VSSSSPSSTP TDSELHGSNS GGNLIGVQLG SMTLGPNANN  60
   61 VAVAGQILGN HYQQQQQHLL QQQQPLLHQN HNQHHMGISQ SHSYNFVGHT VSSSTSQHSS 120
  121 ANEDDMLGP

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [276-402]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QHPQQQPPPP PVASRPERTK SIYTRPIEDL QPAIIPMPVA PATTPATPLQ NHRTPGGISA  60
   61 PAASPMMHNN ATTTLDKNKN NANLYTPEPT VAQVSAGGPS SQVAGNQIAV PQAAVAPAAT 120
  121 PNTRAAN

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 1.09
Match: 2j63A
Description: No description for 2j63A was found.

Predicted Domain #4
Region A:
Residues: [403-704]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AKKKKMSDEE ILEKLRTIVS VGDPNRKYTK MEKIGQGASG TVYTAIESST GMEVAIKQMN  60
   61 LSQQPKKELI INEILVMREN KHPNVVNYLD SYLVSEELWV VMEYLPGGSL TDVVTETCMD 120
  121 EGQIAAVCRE VLQALEFLHA NQVIHRDIKS DNILLGLDGS VKLTDFGFCA QISPEQSKRT 180
  181 TMVGTPYWMA PEVVTRKQYG PKVDLWSLGI MAIEMVEGEP PYLNENPLKA LYLIATNGKP 240
  241 EIKEKDKLSS AFQDFLDQCL EVEVDRRASA LDLLKHPFLK LARPLASLTP LIMAAKEATK 300
  301 GN

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 88.154902
Match: 1f3mC
Description: pak1
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle