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View Structure Prediction Details

Protein: PTP-ER-PA
Organism: Drosophila melanogaster
Length: 1377 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PTP-ER-PA.

Description E-value Query
Range
Subject
Range
gi|54635762|gb|E... - GA22077-PA [Drosophila pseudoobscura], GA22077 [Drosophila pseudoobscura pseudoobscura]
gi|125807989, gi... - gi|54635762|gb|EAL25165.1| GA22077 [Drosophila pseudoobscura pseudoobscura], gi|125807989|ref|XP_001...
1045.0 [0..1] [1377..1]

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Predicted Domain #1
Region A:
Residues: [1-162]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDKLRNNNKE NAPIEYPYPQ TPRPTHAAPS DTTPLEAGED AESNKSTPYF TPLEYLQTSF  60
   61 EFPSPTVEVG GGVPGFPEHE DQEEEVFTPR QFTITSPHPA AHVHHPSSSQ SPTLGRKFKR 120
  121 LSQYDRRSCS PHINTSSGEE RVSGRGIDKE NTMPKGGSVD QD

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [163-296]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LENSLYLSKS EHNSPTILFK DESSTTPGLE ASRLSYSPKL LSSINNLNVS GSPLNIINSA  60
   61 GYKNGNFFRF PEIDHVVQDA PMDTVCLEEA TRRDRSPALA EPPEQQQQKS EGRKNRKNKN 120
  121 NLTIRITDVP IKNS

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [297-566]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SQPSPLPKPK TPTIKSTKEK ARSLDSAANE SELSIVVHNI TESHGSCDDM ETGQSQPSTS  60
   61 VIHHHLHLQQ PASAIHSTSL SRLDSHLSLA NQRRTPRRKS PGINTTDWLM YHRKQNPYQV 120
  121 QPTHCSSTTQ SSLDSDASLT PSLGDFELKS ACSVDGGSKF GIGASLAPRS AHKHNQLLHS 180
  181 SSTNLKTLPE CLTLVEFSSS GGGPKESPFK QKSMDLPMPT LQAKTTVSTS SMNLLQRRGS 240
  241 NHSLTLNLHS SCGNLMNSGL SHSNYSLGSI 

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [567-695]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LNSKSSCNLD AGTASQIRAD QLPQSHLLGS SQGSRQGLFR RRGSNHSITL KTGHTTTSCG  60
   61 DLNSMQQLQQ QQAMLSAEKY NRLNMRTNST GSGSGSGSNV PTPKRGLLER RGSNQSLTLN 120
  121 MGSILGGAA

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [696-1211]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GTEIQMTDIV QPKVTVCSCA AANQAPHQRK FFSTENLNSS KANSQKFFGQ VCFGSASDLQ  60
   61 PNPQQDSVRE DQAIGATCTC AGTVRNIMTR PLSPQTTSEE FKIYLASIQM LQSASNPLNQ 120
  121 FDLIRLNYVF DHSYQTNRNI IEQPPVLGSN ARDVETPTDM VPPSSEDSEL LASYQTVVSR 180
  181 MAQPIPELKE NEQKRIFRDL HKEFWDLPLN HQEKPMVFGS QTKNRYKTIL PNENSRVLLE 240
  241 SESSELTSLL GEIKRTSSVT ASEDLPYINA NYIKGPDYVS KCYVATQGPL PNTIFEFWLM 300
  301 IYQNTQRYIR RCVDGGSSSS PHVDREQILQ QYFQKIVMLT NFTEANRQKC AVYFPIELNE 360
  361 IFAVAAKCEV FQLSAAARDY FDRYLTPTFV PDTVVASSDA IDYEISGRHI GVESVKVTLE 420
  421 GDLLEALPAQ GSFFLIKNVG IVRRNGYSVR KLVLLYCIRV PQSASYHLQK IYCYHYWYPD 480
  481 WPDHHSPRDI NTLLDTCLHV LNLGKCESEF DIYDDT

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 90.30103
Match: 2b3oA
Description: Crystal structure of human tyrosine phosphatase SHP-1
Matching Structure (courtesy of the PDB):

Predicted Domain #6
Region A:
Residues: [1212-1278]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RSERNAHLAA QRLEIYQQDI FNAVQPLPVI HCSAGIGRTG CFTAILNAVR QLRQSLAYSL  60
   61 TGMLTKS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 89.39794
Match: 1ygrA
Description: Crystal structure of the tandem phosphatase domain of RPTP CD45
Matching Structure (courtesy of the PDB):

Predicted Domain #7
Region A:
Residues: [1279-1377]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LTSSSTEEYH NPTDSDSSFT CNTIRHISHI LDHRDAEAVK TPPSFDRLPK MPDIFVDVLG  60
   61 IVCNLRLQRG GMVQNSEQYE LIHRAICLYL KRTLALRRF

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 122.0
Match: 2fh7A
Description: Crystal structure of the phosphatase domains of human PTP SIGMA
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle