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View Structure Prediction Details

Protein: Mlh1-PA
Organism: Drosophila melanogaster
Length: 664 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for Mlh1-PA.

Description E-value Query
Range
Subject
Range
MUTL_PSEE4 - DNA mismatch repair protein MutL OS=Pseudomonas entomophila (strain L48) GN=mutL PE=3 SV=1
gi|95112861 - gi|95112861|emb|CAK17589.1| DNA mismatch repair protein MutL [Pseudomonas entomophila L48]
468.0 [0..8] [639..5]

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Predicted Domain #1
Region A:
Residues: [1-348]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAEYLQPGVI RKLDEVVVNR IAAGEIIQRP ANALKELLEN SLDAQSTHIQ VQVKAGGLKL  60
   61 LQIQDNGTGI RREDLAIVCE RFTTSKLTRF EDLSQIATFG FRGEALASIS HVAHLSIQTK 120
  121 TAKEKCGYKA TYADGKLQGQ PKPCAGNQGT IICIEDLFYN MPQRRQALRS PAEEFQRLSE 180
  181 VLARYAVHNP RVGFTLRKQG DAQPALRTPV ASSRSENIRI IYGAAISKEL LEFSHRDEVY 240
  241 KFEAECLITQ VNYSAKKCQM LLFINQRLVE STALRTSVDS IYATYLPRGH HPFVYMSLTL 300
  301 PPQNLDVNVH PTKHEVHFLY QEEIVDSIKQ QVEARLLGSN ATRTFYKQ

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 85.69897
Match: 1bknA
Description: DNA mismatch repair protein MutL
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [349-459]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LRLPGAPDLD ETQLADKTQR IYPKEMVRTD STEQKLDKFL APLVKSDSGV SSSSSQEASR  60
   61 LPEESFRVTA AKKSREVRLS SVLDMRKRVE RQCSVQLRST LKNLVYVGCV D

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 30.09691
Match: 2gq0A
Description: No description for 2gq0A was found.

Predicted Domain #3
Region A:
Residues: [460-584]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ERRALFQHET RLYMCNTRSF SEELFYQRMI YEFQNCSEIT ISPPLPLKEL LILSLESEAA  60
   61 GWTPEDGDKA ELADGAADIL LKKAPIMREY FGLRISEDGM LESLPSLLHQ HRPCVAHLPV 120
  121 YLLRL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 7.30103
Match: 1x9zA
Description: Crystal structure of the MutL C-terminal domain
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [585-664]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ATEVDWEQET RCFETFCRET ARFYAQLDWR EGATAGFSRW TMEHVLFPAF KKYLLPPPRI  60
   61 KDQIYELTNL PTLYKVFERC 

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle