YRC Public Data Repository - Protein Structure Prediction

Protein:	LYPA2_MOUSE
Organism:	Mus musculus
Length:	231 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for LYPA2_MOUSE.

Description	E-value	Query Range	Subject Range
gi\|41152185, gi\|... - gi\|41152185\|ref\|NP_957043.1\| lysophospholipase II [Danio rerio], gi\|37748063\|gb\|AAH59556.1\| Zgc:7321...	177.0	[0..1]	[231..1]
gi\|39795561, gi\|... - gi\|45361419\|ref\|NP_989287.1\| hypothetical protein LOC394905 [Xenopus (Silurana) tropicalis], gi\|3979...	175.0	[0..1]	[231..1]
gi\|119936523, gi... - gi\|122692349\|ref\|NP_001073831.1\| lysophospholipase II [Bos taurus], gi\|119936523\|gb\|ABM06143.1\| lyso...	175.0	[0..1]	[231..1]
LYPA2_RAT - Acyl-protein thioesterase 2 OS=Rattus norvegicus GN=Lypla2 PE=1 SV=1	174.0	[0..1]	[231..1]
gi\|194207906 - gi\|194207906\|ref\|XP_001501400.2\| PREDICTED: similar to Acyl-protein thioesterase 2 (Lysophospholipas... ENSPTRT00000000662 - null ENSMMUT000000274... - null, null LYPLA2 - lysophospholipase II gi\|124000629, gi... - gi\|157928894\|gb\|ABW03732.1\| lysophospholipase II [synthetic construct], gi\|124000629\|gb\|ABM87823.1\| ... tr\|G1T5V8\|G1T5V8... - pep:novel chromosome:oryCun2:13:129490763:129492747:-1 gene:ENSOCUG00000013660 transcript:ENSOCUT000... tr\|M3X9W1\|M3X9W1... - Lysophospholipase II OS=Felis catus GN=LYPLA2 PE=4 SV=1	174.0	[0..1]	[231..1]
gi\|50737613 - gi\|50737613\|ref\|XP_419203.1\| PREDICTED: similar to Acyl-protein thioesterase 1 (Lysophospholipase I)...	171.0	[0..1]	[231..1]
gi\|148225532, gi... - gi\|27881717\|gb\|AAH44315.1\| MGC52664 protein [Xenopus laevis], gi\|148225532\|ref\|NP_001079559.1\| simil...	170.0	[0..1]	[230..1]

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Predicted Domain #1

Region A:
Residues: [1-231]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MCGNTMSVPL LTDAATVSGA ERETAAVIFL HGLGDTGHSW ADALSTIRLP HVKYICPHAP  60
   61 RIPVTLNMKM VMPSWFDLMG LSPDAPEDEA GIKKAAENIK ALIEHEMKNG IPANRIVLGG 120
  121 FSQGGALSLY TALTCPHPLA GIVALSCWLP LHRNFPQAAN GSAKDLAILQ CHGELDPMVP 180
  181 VRFGALTAEK LRTVVTPARV QFKTYPGVMH SSCPQEMAAV KEFLEKLLPP V

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	38.0
Match:	1fj2A
Description:	Acyl protein thioesterase 1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
hydrolase activity	2.24106351016868	bayes_pls_golite062009
catalytic activity	1.39629727416851	bayes_pls_golite062009
hydrolase activity, acting on ester bonds	1.09488027320166	bayes_pls_golite062009
lipase activity	0.849473630399459	bayes_pls_golite062009
carboxylesterase activity	0.424330502936163	bayes_pls_golite062009
palmitoyl-(protein) hydrolase activity	0.277033874372149	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: