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View Structure Prediction Details

Protein: NTH1_MOUSE, NTHL...
Organism: Mus musculus
Length: 300 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for NTH1_MOUSE, NTHL....

Description E-value Query
Range
Subject
Range
gi|149052032, gi... - gi|34870522|ref|XP_213228.2| PREDICTED: similar to Endonuclease III-like protein 1 [Rattus norvegicu...
254.0 [0..1] [300..1]
gi|116129783, gi... - gi|118782892|ref|XP_312566.3| ENSANGP00000014971 [Anopheles gambiae str. PEST], gi|116129783|gb|EAA0...
239.0 [0..1] [297..1]
NTHL1 - nth endonuclease III-like 1 (E. coli)
237.0 [0..6] [300..15]
gi|109127234 - gi|109127234|ref|XP_001082772.1| PREDICTED: nth endonuclease III-like 1 [Macaca mulatta]
232.0 [0..6] [300..15]
gi|28202547, gi|... - gi|28210111|ref|NP_781055.1| endonuclease III [Clostridium tetani E88], gi|28202547|gb|AAO34992.1| e...
228.0 [0..91] [297..3]
gi|20808188 - gi|20808188|ref|NP_623359.1| predicted EndoIII-related endonuclease [Thermoanaerobacter tengcongensi...
gi|20808188, gi|... - gi|20808188|ref|NP_623359.1| EndoIII-related endonuclease [Thermoanaerobacter tengcongensis MB4], gi...
226.0 [0..87] [298..1]

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Predicted Domain #1
Region A:
Residues: [1-74]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNSGVRMVTR SRSRATRIAS EGCREELAPR EAAAEGRKSH RPVRHPRRTQ KTHVAYEAAN  60
   61 GEEGEDAEPL KVPV

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [75-300]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 WEPQNWQQQL ANIRIMRSKK DAPVDQLGAE HCYDASAPPK VRRYQVLLSL MLSSQTKDQV  60
   61 TAGAMQRLRA RGLTVESILQ TDDDTLGRLI YPVGFWRNKV KYIKQTTAIL QQRYEGDIPA 120
  121 SVAELVALPG VGPKMAHLAM AVAWGTISGI AVDTHVHRIA NRLRWTKKMT KTPEETRKNL 180
  181 EEWLPRVLWS EVNGLLVGFG QQICLPVHPR CQACLNKALC PAAQDL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 58.09691
Match: 2abkA
Description: REFINEMENT OF THE NATIVE STRUCTURE OF ENDONUCLEASE III TO A RESOLUTION OF 1.85 ANGSTROM
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
DNA N-glycosylase activity 4.8124964619976 bayes_pls_golite062009
hydrolase activity, hydrolyzing N-glycosyl compounds 4.26870112679392 bayes_pls_golite062009
DNA-(apurinic or apyrimidinic site) lyase activity 3.71152530486175 bayes_pls_golite062009
oxidized base lesion DNA N-glycosylase activity 2.49872706126491 bayes_pls_golite062009
hydrolase activity 2.39042189031819 bayes_pls_golite062009
8-oxo-7,8-dihydroguanine DNA N-glycosylase activity 2.21048599823382 bayes_pls_golite062009
hydrolase activity, acting on glycosyl bonds 2.18053745735048 bayes_pls_golite062009
catalytic activity 2.13345932727422 bayes_pls_golite062009
damaged DNA binding 2.00388798014411 bayes_pls_golite062009
alkylbase DNA N-glycosylase activity 1.5832578018127 bayes_pls_golite062009
DNA binding 1.44394874535958 bayes_pls_golite062009
nucleic acid binding 1.36800347239439 bayes_pls_golite062009
oxidized purine base lesion DNA N-glycosylase activity 1.32985950765371 bayes_pls_golite062009
oxidized pyrimidine base lesion DNA N-glycosylase activity 1.2016453685638 bayes_pls_golite062009
binding 1.15752946565805 bayes_pls_golite062009
DNA-3-methyladenine glycosylase I activity 1.06383943982125 bayes_pls_golite062009
uracil DNA N-glycosylase activity 0.879508131574476 bayes_pls_golite062009
structure-specific DNA binding 0.85419760398899 bayes_pls_golite062009
purine-specific mismatch base pair DNA N-glycosylase activity 0.68578837518217 bayes_pls_golite062009
mismatch base pair DNA N-glycosylase activity 0.661651574677137 bayes_pls_golite062009
double-stranded DNA binding 0.57099109384393 bayes_pls_golite062009
transcription regulator activity 0.493252955870142 bayes_pls_golite062009
protein binding 0.0921713980805489 bayes_pls_golite062009
carbon-oxygen lyase activity 0.0676784802238829 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle