YRC Public Data Repository - Protein Structure Prediction

Protein:	RISB_STAA9
Organism:	Staphylococcus aureus subsp. aureus JH9
Length:	154 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for RISB_STAA9.

Description	E-value	Query Range	Subject Range
gi\|126699303, gi... - gi\|126699303\|ref\|YP_001088200.1\| riboflavin synthase beta chain (6,7-dimethyl-8-ribityllumazine synt... gi\|255100828 - gi\|255100828\|ref\|ZP_05329805.1\| riboflavin synthase beta chain (6,7-dimethyl-8-ribityllumazine synth... gi\|255306717 - gi\|255306717\|ref\|ZP_05350888.1\| riboflavin synthase beta chain (6,7-dimethyl-8-ribityllumazine synth...	236.0	[0..1]	[152..1]
gi\|255314462 - gi\|255314462\|ref\|ZP_05356045.1\| riboflavin synthase beta chain (6,7-dimethyl-8-ribityllumazine synth... gi\|255517139 - gi\|255517139\|ref\|ZP_05384815.1\| riboflavin synthase beta chain (6,7-dimethyl-8-ribityllumazine synth... gi\|255650244 - gi\|255650244\|ref\|ZP_05397146.1\| riboflavin synthase beta chain (6,7-dimethyl-8-ribityllumazine synth... gi\|254975333 - gi\|254975333\|ref\|ZP_05271805.1\| riboflavin synthase beta chain (6,7-dimethyl-8-ribityllumazine synth... gi\|255092724 - gi\|255092724\|ref\|ZP_05322202.1\| riboflavin synthase beta chain (6,7-dimethyl-8-ribityllumazine synth... gi\|145954563, gi... - gi\|90574741\|ref\|ZP_01231233.1\| hypothetical protein CdifQ_02001808 [Clostridium difficile QCD-32g58]...	236.0	[0..1]	[152..1]
RISB_CALS8 - 6,7-dimethyl-8-ribityllumazine synthase OS=Caldicellulosiruptor saccharolyticus (strain ATCC 43494 /...	227.0	[0..2]	[152..3]
RISB_CLOB8 - 6,7-dimethyl-8-ribityllumazine synthase OS=Clostridium beijerinckii (strain ATCC 51743 / NCIMB 8052)...	227.0	[0..3]	[153..4]
RISB_BACSK - 6,7-dimethyl-8-ribityllumazine synthase OS=Bacillus clausii (strain KSM-K16) GN=ribH PE=3 SV=1	227.0	[0..2]	[153..4]
RISB_STAAE - 6,7-dimethyl-8-ribityllumazine synthase OS=Staphylococcus aureus (strain Newman) GN=ribH PE=3 SV=1 gi\|87126687\|gb\|A... - riboflavin synthase, beta subunit [Staphylococcus aureus subsp. aureus USA300], riboflavin synthase,... RISB_STAA8 - 6,7-dimethyl-8-ribityllumazine synthase OS=Staphylococcus aureus (strain NCTC 8325) GN=ribH PE=3 SV=... gi\|221140250 - gi\|221140250\|ref\|ZP_03564743.1\| riboflavin synthase subunit beta [Staphylococcus aureus subsp. aureu... RISB_STAAB - 6,7-dimethyl-8-ribityllumazine synthase OS=Staphylococcus aureus (strain bovine RF122 / ET3-1) GN=ri... RISB_STAA3 - 6,7-dimethyl-8-ribityllumazine synthase OS=Staphylococcus aureus (strain USA300) GN=ribH PE=3 SV=1 gi\|221137181 - gi\|221137181\|ref\|ZP_03561992.1\| riboflavin synthase subunit beta [Staphylococcus aureus subsp. aureu... RISB_STAAT - 6,7-dimethyl-8-ribityllumazine synthase OS=Staphylococcus aureus (strain USA300 / TCH1516) GN=ribH P... RISB_STAAC - 6,7-dimethyl-8-ribityllumazine synthase OS=Staphylococcus aureus (strain COL) GN=ribH PE=3 SV=1 gi\|253732419, gi... - gi\|253732419\|ref\|ZP_04866584.1\| riboflavin synthase, beta subunit [Staphylococcus aureus subsp. aure... gi\|253726664, gi... - gi\|253735375\|ref\|ZP_04869540.1\| riboflavin synthase, beta subunit [Staphylococcus aureus subsp. aure...	227.0	[0..1]	[154..1]
gi\|255270243, gi... - gi\|255339106\|ref\|ZP_05379952.1\| 6,7-dimethyl-8-ribityllumazine synthase [Thermoanaerobacter mathrani... gi\|242232021, gi... - gi\|242256428\|ref\|ZP_04801319.1\| 6,7-dimethyl-8-ribityllumazine synthase [Thermoanaerobacter sp. X513... RISB_THEPX - 6,7-dimethyl-8-ribityllumazine synthase OS=Thermoanaerobacter sp. (strain X514) GN=ribH PE=3 SV=1	226.0	[0..3]	[153..4]
RISB_THEP3 - 6,7-dimethyl-8-ribityllumazine synthase OS=Thermoanaerobacter pseudethanolicus (strain ATCC 33223 / ... gi\|241903097, gi... - gi\|241903097\|ref\|ZP_04787825.1\| 6,7-dimethyl-8-ribityllumazine synthase [Thermoanaerobacter brockii ...	225.0	[0..3]	[153..4]
gi\|148992756, gi... - gi\|148992756\|ref\|ZP_01822399.1\| 6,7-dimethyl-8-ribityllumazine synthase [Streptococcus pneumoniae SP... gi\|147926377, gi... - gi\|148987913\|ref\|ZP_01819376.1\| 6,7-dimethyl-8-ribityllumazine synthase [Streptococcus pneumoniae SP... gi\|148983577, gi... - gi\|148983577\|ref\|ZP_01816896.1\| 6,7-dimethyl-8-ribityllumazine synthase [Streptococcus pneumoniae SP... RISB_STRPN - 6,7-dimethyl-8-ribityllumazine synthase OS=Streptococcus pneumoniae GN=ribH PE=3 SV=1 RISB_STRPN - 6,7-dimethyl-8-ribityllumazine synthase OS=Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 ... RISB_STRR6 - 6,7-dimethyl-8-ribityllumazine synthase OS=Streptococcus pneumoniae (strain ATCC BAA-255 / R6) GN=ri... gi\|183570838, gi... - gi\|183570838\|gb\|EDT91366.1\| 6,7-dimethyl-8-ribityllumazine synthase [Streptococcus pneumoniae CDC108... gi\|172042822, gi... - gi\|172042822\|gb\|EDT50868.1\| 6,7-dimethyl-8-ribityllumazine synthase [Streptococcus pneumoniae CDC187... gi\|183573595, gi... - gi\|183573595\|gb\|EDT94123.1\| 6,7-dimethyl-8-ribityllumazine synthase [Streptococcus pneumoniae CDC028... gi\|168490359, gi... - gi\|183571316\|gb\|EDT91844.1\| 6,7-dimethyl-8-ribityllumazine synthase [Streptococcus pneumoniae SP195]... gi\|168576393, gi... - gi\|183577842\|gb\|EDT98370.1\| 6,7-dimethyl-8-ribityllumazine synthase [Streptococcus pneumoniae MLV-01... gi\|168493873, gi... - gi\|183576061\|gb\|EDT96589.1\| 6,7-dimethyl-8-ribityllumazine synthase [Streptococcus pneumoniae CDC305... RISB_STRPS - 6,7-dimethyl-8-ribityllumazine synthase OS=Streptococcus pneumoniae (strain CGSP14) GN=ribH PE=3 SV=... RISB_STRPI - 6,7-dimethyl-8-ribityllumazine synthase OS=Streptococcus pneumoniae (strain Hungary19A-6) GN=ribH PE... RISB_STRPJ - 6,7-dimethyl-8-ribityllumazine synthase OS=Streptococcus pneumoniae (strain ATCC 700669 / Spain 23F-... RISB_STRP2 - 6,7-dimethyl-8-ribityllumazine synthase OS=Streptococcus pneumoniae serotype 2 (strain D39 / NCTC 74... RISB_STRP4 - 6,7-dimethyl-8-ribityllumazine synthase OS=Streptococcus pneumoniae serotype 19F (strain G54) GN=rib... gi\|147764683, gi... - gi\|149011047\|ref\|ZP_01832352.1\| 6,7-dimethyl-8-ribityllumazine synthase [Streptococcus pneumoniae SP... gi\|147762284, gi... - gi\|149005928\|ref\|ZP_01829657.1\| 6,7-dimethyl-8-ribityllumazine synthase [Streptococcus pneumoniae SP... gi\|149001720, gi... - gi\|149001720\|ref\|ZP_01826693.1\| 6,7-dimethyl-8-ribityllumazine synthase [Streptococcus pneumoniae SP... gi\|148996601, gi... - gi\|148996601\|ref\|ZP_01824319.1\| 6,7-dimethyl-8-ribityllumazine synthase [Streptococcus pneumoniae SP... RISB_STRZJ - 6,7-dimethyl-8-ribityllumazine synthase OS=Streptococcus pneumoniae (strain JJA) GN=ribH PE=3 SV=1 RISB_STRZP - 6,7-dimethyl-8-ribityllumazine synthase OS=Streptococcus pneumoniae (strain P1031) GN=ribH PE=3 SV=1 RISB_STRP7 - 6,7-dimethyl-8-ribityllumazine synthase OS=Streptococcus pneumoniae (strain 70585) GN=ribH PE=3 SV=1 RISB_STRZT - 6,7-dimethyl-8-ribityllumazine synthase OS=Streptococcus pneumoniae (strain Taiwan19F-14) GN=ribH PE... gi\|237649751 - gi\|237649751\|ref\|ZP_04524003.1\| riboflavin synthase subunit beta [Streptococcus pneumoniae CCRI 1974... gi\|237821449 - gi\|237821449\|ref\|ZP_04597294.1\| riboflavin synthase subunit beta [Streptococcus pneumoniae CCRI 1974... gi\|242246256, gi... - gi\|242246256\|ref\|ZP_04800693.1\| riboflavin synthase, beta subunit [Streptococcus pneumoniae TCH8431/...	225.0	[0..2]	[154..3]
RISB_GEOSL - 6,7-dimethyl-8-ribityllumazine synthase OS=Geobacter sulfurreducens GN=ribH PE=3 SV=1 RISB_GEOSL - 6,7-dimethyl-8-ribityllumazine synthase OS=Geobacter sulfurreducens (strain ATCC 51573 / DSM 12127 /...	224.0	[0..3]	[153..5]

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Predicted Domain #1

Region A:
Residues: [1-154]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNFEGKLIGK DLKVAIVVSR FNDFITGRLL EGAKDTLIRH DVNEDNIDVA FVPGAFEIPL  60
   61 VAKKLASSGN YDAIITLGCV IRGATSHYDY VCNEVAKGVS KVNDQTNVPV IFGILTTESI 120
  121 EQAVERAGTK AGNKGAEAAV SAIEMANLLK SIKA

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	57.0
Match:	1rvvA
Description:	Lumazine synthase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
6,7-dimethyl-8-ribityllumazine synthase activity	5.61825642183907	bayes_pls_golite062009
intramolecular transferase activity, transferring acyl groups	4.02275160603209	bayes_pls_golite062009
catalytic activity	1.78070169551865	bayes_pls_golite062009
riboflavin synthase activity	1.72639804812167	bayes_pls_golite062009
isomerase activity	0.268840799327499	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: