YRC Public Data Repository - Protein Structure Prediction

Protein:	PDX1
Organism:	Homo sapiens
Length:	283 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PDX1.

Description	E-value	Query Range	Subject Range
gi\|50838802, gi\|... - gi\|50838802\|ref\|NP_074043.3\| pancreatic and duodenal homeobox 1 [Rattus norvegicus], gi\|454392\|gb\|AA...	8.0E-31	[1..283]	[1..283]
PDX1_PANTR - Pancreas/duodenum homeobox protein 1 OS=Pan troglodytes GN=PDX1 PE=3 SV=1	1.0E-30	[1..283]	[1..283]
PDX1_MESAU - Pancreas/duodenum homeobox protein 1 OS=Mesocricetus auratus GN=PDX1 PE=1 SV=1	8.0E-30	[1..283]	[1..283]
gi\|2935557 - gi\|2935557\|gb\|AAC05157.1\| insulin upstream factor 1 [Homo sapiens]	1.0E-29	[1..283]	[1..283]
gi\|109120277 - gi\|109120277\|ref\|XP_001096758.1\| PREDICTED: insulin promoter factor 1, homeodomain transcription fac...	2.0E-28	[1..283]	[1..281]
PDX1_MOUSE - Pancreas/duodenum homeobox protein 1 OS=Mus musculus GN=Pdx1 PE=1 SV=1	3.0E-28	[1..283]	[1..284]
HXC6A_TAKRU - Homeobox protein Hox-C6a OS=Takifugu rubripes GN=hoxc6a PE=3 SV=1	4.0E-27	[1..204]	[1..198]
PDX1_XENLA - Pancreas/duodenum homeobox protein 1 OS=Xenopus laevis GN=pdx1 PE=2 SV=2	9.0E-27	[1..260]	[1..261]

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Predicted Domain #1

Region A:
Residues: [1-102]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNGEEQYYAA TQLYKDPCAF QRGPAPEFSA SPPACLYMGR QPPPPPPHPF PGALGALEQG  60
   61 SPPDISPYEV PPLADDPAVA HLHHHLPAQL ALPHPPAGPF PE

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2

Region A:
Residues: [103-283]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GAEPGVLEEP NRVQLPFPWM KSTKAHAWKG QWAGGAYAAE PEENKRTRTA YTRAQLLELE  60
   61 KEFLFNKYIS RPRRVELAVM LNLTERHIKI WFQNRRMKWK KEEDKKRGGG TAVGGGGVAE 120
  121 PEQDCAVTSG EELLALPPPP PPGGAVPPAA PVAAREGRLP PGLSASPQPS SVAPRRPQEP 180
  181 R

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	24.39794
Match:	2h1kA
Description:	No description for 2h1kA was found.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits