YRC Public Data Repository - Protein Structure Prediction

Protein:	PFKFB2
Organism:	Homo sapiens
Length:	505 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PFKFB2.

Description	E-value	Query Range	Subject Range
gi\|3090419 - gi\|3090419\|emb\|CAA06605.1\| 6-phosphofructo-2-kinase [Homo sapiens]	0.0	[1..505]	[1..504]
gi\|56403556 - gi\|56403556\|emb\|CAI29582.1\| hypothetical protein [Pongo abelii] F262_PONAB - 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 OS=Pongo abelii GN=PFKFB2 PE=2 SV=1	0.0	[1..503]	[1..503]
gi\|73960683 - gi\|73960683\|ref\|XP_537134.2\| PREDICTED: similar to 6-phosphofructo-2-kinase/fructose-2,6-biphosphata...	0.0	[1..505]	[1..507]
gi\|148707789, gi... - gi\|74145062\|dbj\|BAE27404.1\| unnamed protein product [Mus musculus], gi\|34147045\|ref\|NP_032851.2\| 6-p...	0.0	[2..505]	[4..507]
gi\|8307716, gi\|1... - gi\|8307722\|dbj\|BAA96498.1\| RH2K6 [Rattus norvegicus], gi\|8307716\|dbj\|BAA96495.1\| RH2K1 [Rattus norve...	0.0	[14..505]	[17..508]
F262_BOVIN - 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 OS=Bos taurus GN=PFKFB2 PE=1 SV=2	0.0	[1..505]	[1..506]

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Predicted Domain #1

Region A:
Residues: [1-505]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSGASSSEQN NNSYETKTPN LRMSEKKCSW ASYMTNSPTL IVMIGLPARG KTYVSKKLTR  60
   61 YLNWIGVPTK VFNLGVYRRE AVKSYKSYDF FRHDNEEAMK IRKQCALVAL EDVKAYLTEE 120
  121 NGQIAVFDAT NTTRERRDMI LNFAEQNSFK VFFVESVCDD PDVIAANILE VKVSSPDYPE 180
  181 RNRENVMEDF LKRIECYKVT YRPLDPDNYD KDLSFIKVIN VGQRFLVNRV QDYIQSKIVY 240
  241 YLMNIHVQPR TIYLCRHGES EFNLLGKIGG DSGLSVRGKQ FAQALRKFLE EQEITDLKVW 300
  301 TSQLKRTIQT AESLGVPYEQ WKILNEIDAG VCEEMTYAEI EKRYPEEFAL RDQEKYLYRY 360
  361 PGGESYQDLV QRLEPVIMEL ERQGNVLVIS HQAVMRCLLA YFLDKGADEL PYLRCPLHTI 420
  421 FKLTPVAYGC KVETIKLNVE AVNTHRDKPT NNFPKNQTPV RMRRNSFTPL SSSNTIRRPR 480
  481 NYSVGSRPLK PLSPLRAQDM QEGAD

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	144.0
Match:	2axnA
Description:	Crystal structure of the human inducible form 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits