YRC Public Data Repository - Protein Structure Prediction

Protein:	AURKB
Organism:	Homo sapiens
Length:	344 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for AURKB.

Description	E-value	Query Range	Subject Range
gi\|109113312 - gi\|109113312\|ref\|XP_001118154.1\| PREDICTED: aurora kinase B [Macaca mulatta]	315.0	[0..1]	[344..219]
gi\|115749607, gi... - gi\|115749607\|ref\|NP_898907.2\| aurora kinase B [Bos taurus], gi\|115304919\|gb\|AAI23651.1\| Aurora kinas...	314.0	[0..1]	[343..1]
gi\|114669324 - gi\|114669324\|ref\|XP_511856.2\| PREDICTED: aurora kinase B [Pan troglodytes]	312.0	[0..1]	[344..52]
gi\|61365596, gi\|... - gi\|61365596\|gb\|AAX42733.1\| aurora kinase B [synthetic construct], gi\|54695936\|gb\|AAV38340.1\| serine/...	311.0	[0..1]	[344..1]
gi\|83776600, gi\|... - gi\|83776600\|ref\|NP_004208.2\| aurora kinase B [Homo sapiens], gi\|14602490\|gb\|AAH09751.1\| Aurora kinas...	311.0	[0..1]	[344..1]
PK2_DICDI - Protein kinase 2 - Dictyostelium discoideum (Slime mold)	309.0	[0..3]	[335..74]
gi\|66804103, gi\|... - gi\|66804103\|ref\|XP_635853.1\| protein kinase 2 [Dictyostelium discoideum AX4], gi\|60464191\|gb\|EAL6235... PK2_DICDI - Protein kinase 2 OS=Dictyostelium discoideum GN=pkgB PE=1 SV=2	309.0	[0..3]	[335..74]
gi\|47522646, gi\|... - gi\|47522646\|ref\|NP_999084.1\| aurora kinase B [Sus scrofa], gi\|33355450\|gb\|AAQ16150.1\| serine/threoni...	308.0	[0..1]	[343..1]

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Predicted Domain #1

Region A:
Residues: [1-344]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAQKENSYPW PYGRQTAPSG LSTLPQRVLR KEPVTPSALV LMSRSNVQPT AAPGQKVMEN  60
   61 SSGTPDILTR HFTIDDFEIG RPLGKGKFGN VYLAREKKSH FIVALKVLFK SQIEKEGVEH 120
  121 QLRREIEIQA HLHHPNILRL YNYFYDRRRI YLILEYAPRG ELYKELQKSC TFDEQRTATI 180
  181 MEELADALMY CHGKKVIHRD IKPENLLLGL KGELKIADFG WSVHAPSLRR KTMCGTLDYL 240
  241 PPEMIEGRMH NEKVDLWCIG VLCYELLVGN PPFESASHNE TYRRIVKVDL KFPASVPTGA 300
  301 QDLISKLLRH NPSERLPLAQ VSAHPWVRAN SRRVLPPSAL QSVA

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	67.69897
Match:	2bfxA
Description:	Mechanism of Aurora-B activation by INCENP and inhibition by Hesperadin.
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits