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View Structure Prediction Details

Protein: KRT8
Organism: Homo sapiens
Length: 483 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for KRT8.

Description E-value Query
Range
Subject
Range
gi|114625886 - gi|114625886|ref|XP_520149.2| PREDICTED: similar to OTTHUMP00000021786 [Pan troglodytes]
7.0E-70 [4..483] [283..762]
gi|109481333 - gi|109481333|ref|XP_001064779.1| PREDICTED: similar to keratin Kb40 [Rattus norvegicus]
2.0E-69 [1..405] [149..569]
gi|73996557 - gi|73996557|ref|XP_850166.1| PREDICTED: similar to keratin, hair, basic, 3 [Canis familiaris]
4.0E-69 [13..404] [124..515]
gi|109096771 - gi|109096771|ref|XP_001093676.1| PREDICTED: keratin, hair, basic, 4 [Macaca mulatta]
2.0E-67 [4..404] [57..478]
gi|42760016 - gi|42760016|emb|CAF31524.1| type II hair keratin 4 [Homo sapiens]
1.0E-65 [11..404] [78..476]

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Predicted Domain #1
Region A:
Residues: [1-73]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSIRVTQKSY KVSTSGPRAF SSRSYTSGPG SRISSSSFSR VGSSNFRGGL GGGYGGASGM  60
   61 GGITAVTVNQ SLL

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [74-152]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SPLVLEVDPN IQAVRTQEKE QIKTLNNKFA SFIDKVRFLE QQNKMLETKW SLLQQQKTAR  60
   61 SNMDNMFESY INNLRRQLE

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 10.69897
Match: 1c1gA
Description: Tropomyosin
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [153-483]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TLGQEKLKLE AELGNMQGLV EDFKNKYEDE INKRTEMENE FVLIKKDVDE AYMNKVELES  60
   61 RLEGLTDEIN FLRQLYEEEI RELQSQISDT SVVLSMDNSR SLDMDSIIAE VKAQYEDIAN 120
  121 RSRAEAESMY QIKYEELQSL AGKHGDDLRR TKTEISEMNR NISRLQAEIE GLKGQRASLE 180
  181 AAIADAEQRG ELAIKDANAK LSELEAALQR AKQDMARQLR EYQELMNVKL ALDIEIATYR 240
  241 KLLEGEESRL ESGMQNMSIH TKTTSGYAGG LSSAYGGLTS PGLSYSLGSS FGSGAGSSSF 300
  301 SRTSSSRAVV VKKIETRDGK LVSESSDVLP K

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 15.0
Match: 1i84S
Description: Heavy meromyosin subfragment
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle