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View Structure Prediction Details

Protein: NDC80
Organism: Homo sapiens
Length: 642 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for NDC80.

Description E-value Query
Range
Subject
Range
MYH2_PIG - Myosin-2 OS=Sus scrofa GN=MYH2 PE=2 SV=1
gi|55741490 - ref|NP_999301.1| myosin heavy chain 2a [Sus scrofa]
1.0E-47 [84..642] [841..1391]
MYH2_BOVIN - Myosin-2 OS=Bos taurus GN=MYH2 PE=2 SV=1
5.0E-47 [84..642] [842..1392]
MYH2_HORSE - Myosin-2 OS=Equus caballus GN=MYH2 PE=2 SV=1
5.0E-47 [84..642] [839..1389]
gi|42476190, gi|... - gi|42476190|ref|NP_060004.2| myosin, heavy polypeptide 2, skeletal muscle, adult [Homo sapiens], gi|...
6.0E-47 [84..642] [843..1393]
gi|109113271 - gi|109113271|ref|XP_001113877.1| PREDICTED: myosin, heavy polypeptide 2, skeletal muscle, adult [Mac...
7.0E-47 [84..642] [841..1391]
gi|109488222 - gi|109488222|ref|XP_001077587.1| PREDICTED: similar to Myosin heavy chain, skeletal muscle, adult 2 ...
1.0E-46 [84..642] [833..1383]

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Predicted Domain #1
Region A:
Residues: [1-83]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKRSSVSSGG AGRLSMQELR SQDVNKQGLY TPQTKEKPTF GKLSINKPTS ERKVSLFGKR  60
   61 TSGHGSRNSQ LGIFSSSEKI KDP

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [84-398]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RPLNDKAFIQ QCIRQLCEFL TENGYAHNVS MKSLQAPSVK DFLKIFTFLY GFLCPSYELP  60
   61 DTKFEEEVPR IFKDLGYPFA LSKSSMYTVG APHTWPHIVA ALVWLIDCIK IHTAMKESSP 120
  121 LFDDGQPWGE ETEDGIMHNK LFLDYTIKCY ESFMSGADSF DEMNAELQSK LKDLFNVDAF 180
  181 KLESLEAKNR ALNEQIARLE QEREKEPNRL ESLRKLKASL QGDVQKYQAY MSNLESHSAI 240
  241 LDQKLNGLNE EIARVELECE TIKQENTRLQ NIIDNQKYSV ADIERINHER NELQQTINKL 300
  301 TKDLEAEQQK LWNEE

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 20.045757
Match: 1i84S
Description: Heavy meromyosin subfragment
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [399-461]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LKYARGKEAI ETQLAEYHKL ARKLKLIPKG AENSKGYDFE IKFNPEAGAN CLVKYRAQVY  60
   61 VPL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 10.522879
Match: 1c1gA
Description: Tropomyosin
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [462-642]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KELLNETEEE INKALNKKMG LEDTLEQLNA MITESKRSVR TLKEEVQKLD DLYQQKIKEA  60
   61 EEEDEKCASE LESLEKHKHL LESTVNQGLS EAMNELDAVQ REYQLVVQTT TEERRKVGNN 120
  121 LQRLLEMVAT HVGSVEKHLE EQIAKVDREY EECMSEDLSE NIKEIRDKYE KKATLIKSSE 180
  181 E

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 1.51
Match: 1jchA
Description: Ribonuclease domain of colicin E3; Colicin E3 translocation domain; Colicin E3 receptor domain
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle