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View Structure Prediction Details

Protein: PLD1
Organism: Homo sapiens
Length: 1074 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PLD1.

Description E-value Query
Range
Subject
Range
PLD1_RAT - Phospholipase D1 OS=Rattus norvegicus GN=Pld1 PE=1 SV=3
957.0 [0..1] [1074..1]
PLD1_MOUSE - Phospholipase D1 OS=Mus musculus GN=Pld1 PE=2 SV=1
948.0 [0..1] [1074..1]
gi|109044279 - gi|109044279|ref|XP_001085464.1| PREDICTED: phospholipase D1, phophatidylcholine-specific [Macaca mu...
943.0 [0..1] [1074..1]
gi|114590416 - gi|114590416|ref|XP_526380.2| PREDICTED: phospholipase D1, phophatidylcholine-specific [Pan troglody...
934.0 [0..1] [1074..90]
gi|62089400 - gi|62089400|dbj|BAD93144.1| phospholipase D1 variant [Homo sapiens]
931.0 [0..1] [1074..24]

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Predicted Domain #1
Region A:
Residues: [1-78]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSLKNEPRVN TSALQKIAAD MSNIIENLDT RELHFEGEEV DYDVSPSDPK IQEVYIPFSA  60
   61 IYNTQGFKEP NIQTYLSG

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [79-230]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 CPIKAQVLEV ERFTSTTRVP SINLYTIELT HGEFKWQVKR KFKHFQEFHR ELLKYKAFIR  60
   61 IPIPTRRHTF RRQNVREEPR EMPSLPRSSE NMIREEQFLG RRKQLEDYLT KILKMPMYRN 120
  121 YHATTEFLDI SQLSFIHDLG PKGIEGMIMK RS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 24.30103
Match: 1xteA
Description: crystal structure of CISK-PX domain
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [231-339]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GGHRIPGLNC CGQGRACYRW SKRWLIVKDS FLLYMKPDSG AIAFVLLVDK EFKIKVGKKE  60
   61 TETKYGIRID NLSRTLILKC NSYRHARWWG GAIEEFIQKH GTNFLKDHR

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 4.69897
Match: 2dn6A
Description: No description for 2dn6A was found.

Predicted Domain #4
Region A:
Residues: [340-529]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FGSYAAIQEN ALAKWYVNAK GYFEDVANAM EEANEEIFIT DWWLSPEIFL KRPVVEGNRW  60
   61 RLDCILKRKA QQGVRIFIML YKEVELALGI NSEYTKRTLM RLHPNIKVMR HPDHVSSTVY 120
  121 LWAHHEKLVI IDQSVAFVGG IDLAYGRWDD NEHRLTDVGS VKRVTSGPSL GSLPPAAMES 180
  181 MESLRLKDKN 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 10.39794
Match: 1byrA
Description: Nuclease Nuc
Matching Structure (courtesy of the PDB):

Predicted Domain #5
Region A:
Residues: [530-966]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EPVQNLPIQK SIDDVDSKLK GIGKPRKFSK FSLYKQLHRH HLHDADSISS IDSTSSYFNH  60
   61 YRSHHNLIHG LKPHFKLFHP SSESEQGLTR PHADTGSIRS LQTGVGELHG ETRFWHGKDY 120
  121 CNFVFKDWVQ LDKPFADFID RYSTPRMPWH DIASAVHGKA ARDVARHFIQ RWNFTKIMKS 180
  181 KYRSLSYPFL LPKSQTTAHE LRYQVPGSVH ANVQLLRSAA DWSAGIKYHE ESIHAAYVHV 240
  241 IENSRHYIYI ENQFFISCAD DKVVFNKIGD AIAQRILKAH RENQKYRVYV VIPLLPGFEG 300
  301 DISTGGGNAL QAIMHFNYRT MCRGENSILG QLKAELGNQW INYISFCGLR THAELEGNLV 360
  361 TELIYVHSKL LIADDNTVII GSANINDRSM LGKRDSEMAV IVQDTETVPS VMDGKEYQAG 420
  421 RFARGLRLQC FRVVLGY

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 17.39794
Match: 1f0iA
Description: Phospholipase D
Matching Structure (courtesy of the PDB):

Predicted Domain #6
Region A:
Residues: [967-1074]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LDDPSEDIQD PVSDKFFKEV WVSTAARNAT IYDKVFRCLP NDEVHNLIQL RDFINKPVLA  60
   61 KEDPIRAEEE LKKIRGFLVQ FPFYFLSEES LLPSVGTKEA IVPMEVWT

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.883 a.8.4 Description not found.


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