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View Structure Prediction Details

Protein: ADAM33
Organism: Homo sapiens
Length: 813 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ADAM33.

Description E-value Query
Range
Subject
Range
gi|109459525, gi... - gi|109463065|ref|XP_001055685.1| PREDICTED: similar to ADAM 12 precursor (A disintegrin and metallop...
416.0 [0..30] [808..107]
gi|18030088 - gi|18030088|gb|AAL56617.1|AF456466_1 ADAM 12 [Coturnix coturnix]
410.0 [0..31] [810..51]
gi|45220004, gi|... - gi|47564064|ref|NP_001001156.1| ADAM metallopeptidase domain 12 [Bos taurus], gi|45220004|dbj|BAD122...
409.0 [0..28] [808..43]
gi|21908028, gi|... - gi|21908030|gb|AAM80483.1| a disintegrin and metalloprotease domain 33 [Homo sapiens], gi|21908028|g...
405.0 [0..1] [813..1]
gi|28972033 - gi|28972033|dbj|BAC65470.1| mKIAA0021 protein [Mus musculus]
405.0 [0..1] [804..9]
gi|114603120 - gi|114603120|ref|XP_001137770.1| PREDICTED: ADAM metallopeptidase domain 19 isoform 3 [Pan troglodyt...
404.0 [0..10] [780..6]

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Predicted Domain #1
Region A:
Residues: [1-72]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGWRPRRARG TPLLLLLLLL LLWPVPGAGV LQGHIPGQPV TPHWVLDGQP WRTVSLEEPV  60
   61 SKPDMGLVAL EA

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [73-198]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EGQELLLELE KNHRLLAPGY IETHYGPDGQ PVVLAPNHTD HCHYQGRVRG FPDSWVVLCT  60
   61 CSGMSGLITL SRNASYYLRP WPPRGSKDFS THEIFRMEQL LTWKGTCGHR DPGNKAGMTS 120
  121 LPGGPQ

[Run NCBI BLAST on this sequence.]

Detection Method: Pfam
Confidence: 31.769551
Match: PF01562.8
Description: No description for PF01562.8 was found.

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [199-333]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SRGRREARRT RKYLELYIVA DHTLFLTRHR NLNHTKQRLL EVANYVDQLL RTLDIQVALT  60
   61 GLEVWTERDR SRVTQDANAT LWAFLQWRRG LWAQRPHDSA QLLTGRAFQG ATVGLAPVEG 120
  121 MCRAESSGGV STDHS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 34.522879
Match: 1dthA
Description: Snake venom metalloprotease
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [334-734]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ELPIGAAATM AHEIGHSLGL SHDPDGCCVE AAAESGGCVM AAATGHPFPR VFSACSRRQL  60
   61 RAFFRKGGGA CLSNAPDPGL PVPPALCGNG FVEAGEECDC GPGQECRDLC CFAHNCSLRP 120
  121 GAQCAHGDCC VRCLLKPAGA LCRQAMGDCD LPEFCTGTSS HCPPDVYLLD GSPCARGSGY 180
  181 CWDGACPTLE QQCQQLWGPG SHPAPEACFQ VVNSAGDAHG NCGQDSEGHF LPCAGRDALC 240
  241 GKLQCQGGKP SLLAPHMVPV DSTVHLDGQE VTCRGALALP SAQLDLLGLG LVEPGTQCGP 300
  301 RMVCQSRRCR KNAFQELQRC LTACHSHGVC NSNHNCHCAP GWAPPFCDKP GFGGSMDSGP 360
  361 VQAENHDTFL LAMLLSVLLP LLPGAGLAWC CYRLPGAHLQ R

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 12.30103
Match: 1n7dA
Description: Low density lipoprotein (LDL) receptor YWTD domain; Low density lipoprotein (LDL) receptor, different EGF domains; Ligand-binding domain of low-density lipoprotein receptor
Matching Structure (courtesy of the PDB):

Predicted Domain #5
Region A:
Residues: [735-813]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 CSWGCRRDPA CSGPKDGPHR DHPLGGVHPM ELGPTATGQP WPLDPENSHE PSSHPEKPLP  60
   61 AVSPDPQADQ VQMPRSCLW

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle