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View Structure Prediction Details

Protein: ERCC1
Organism: Homo sapiens
Length: 297 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ERCC1.

Description E-value Query
Range
Subject
Range
gi|61367243, gi|... - gi|61367243|gb|AAX42971.1| excision repair cross-complementing rodent repair deficiency complementat...
2.0E-78 [1..297] [1..297]
gi|114677849, gi... - gi|114677849|ref|XP_001164706.1| PREDICTED: excision repair cross-complementing 1 isoform 6 [Pan tro...
2.0E-76 [1..297] [1..300]
gi|109458301, gi... - ref|XP_214833.1| similar to excision repair cross-complementing rodent repair deficiency, complement...
3.0E-72 [1..297] [1..297]
gi|42544169, gi|... - gi|42544169|ref|NP_973730.1| excision repair cross-complementing 1 isoform 1 [Homo sapiens], gi|3112...
8.0E-72 [1..285] [1..285]
ERCC1_MOUSE - DNA excision repair protein ERCC-1 OS=Mus musculus GN=Ercc1 PE=2 SV=2
2.0E-71 [1..297] [1..297]

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Predicted Domain #1
Region A:
Residues: [1-93]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDPGKDKEGV PQPSGPPARK KFVIPLDEDE VPPGVAKPLF RSTQSLPTVD TSAQAAPQTY  60
   61 AEYAISQPLE GAGATCPTGS EPLAGETPNQ ALK

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [94-147]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PGAKSNSIIV SPRQRGNPVL KFVRNVPWEF GDVIPDYVLG QSTCALFLSL RYHN

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 26.522879
Match: 2a1iA
Description: Crystal Structure of the Central Domain of Human ERCC1
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [148-219]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LHPDYIHGRL QSLGKNFALR VLLVQVDVKD PQQALKELAK MCILADCTLI LAWSPEEAGR  60
   61 YLETYKAYEQ KP

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 4.81
Match: 2a1iA
Description: Crystal Structure of the Central Domain of Human ERCC1
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [220-297]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ADLLMEKLEQ DFVSRVTECL TTVKSVNKTD SQTLLTTFGS LEQLIAASRE DLALCPGLGP  60
   61 QKARRLFDVL HEPFLKVP

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 20.0
Match: 1z00A
Description: Solution structure of the C-terminal domain of ERCC1 complexed with the C-terminal domain of XPF
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle