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View Structure Prediction Details

Protein: PLK1
Organism: Homo sapiens
Length: 603 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PLK1.

Description E-value Query
Range
Subject
Range
gi|74195187 - gi|74195187|dbj|BAE28328.1| unnamed protein product [Mus musculus]
0.0 [1..603] [1..603]
gi|53734301 - gi|53734301|gb|AAH83926.1| Plk1 protein [Rattus norvegicus]
0.0 [1..603] [1..603]
gi|60652559, gi|... - gi|60652561|gb|AAX28975.1| polo-like kinase 1 [synthetic construct], gi|60652559|gb|AAX28974.1| polo...
0.0 [1..603] [1..603]
gi|109103744 - gi|109103744|ref|XP_001092070.1| PREDICTED: polo-like kinase [Macaca mulatta]
0.0 [1..603] [1..603]
gi|67969022 - gi|67969022|dbj|BAE00866.1| unnamed protein product [Macaca fascicularis]
0.0 [1..603] [1..603]
gi|114661622 - gi|114661622|ref|XP_001163623.1| PREDICTED: polo-like kinase isoform 2 [Pan troglodytes]
0.0 [1..603] [1..603]
gi|403458 - gi|403458|gb|AAA36659.1| protein kinase
0.0 [1..603] [1..603]

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Predicted Domain #1
Region A:
Residues: [1-344]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSAAVTAGKL ARAPADPGKA GVPGVAAPGA PAAAPPAKEI PEVLVDPRSR RRYVRGRFLG  60
   61 KGGFAKCFEI SDADTKEVFA GKIVPKSLLL KPHQREKMSM EISIHRSLAH QHVVGFHGFF 120
  121 EDNDFVFVVL ELCRRRSLLE LHKRRKALTE PEARYYLRQI VLGCQYLHRN RVIHRDLKLG 180
  181 NLFLNEDLEV KIGDFGLATK VEYDGERKKT LCGTPNYIAP EVLSKKGHSF EVDVWSIGCI 240
  241 MYTLLVGKPP FETSCLKETY LRIKKNEYSI PKHINPVAAS LIQKMLQTDP TARPTINELL 300
  301 NDEFFTSGYI PARLPITCLT IPPRFSIAPS SLDPSNRKPL TVLN

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 68.221849
Match: 2ou7A
Description: No description for 2ou7A was found.

Predicted Domain #2
Region A:
Residues: [345-508]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KGLENPLPER PREKEEPVVR ETGEVVDCHL SDMLQQLHSV NASKPSERGL VRQEEAEDPA  60
   61 CIPIFWVSKW VDYSDKYGLG YQLCDNSVGV LFNDSTRLIL YNDGDSLQYI ERDGTESYLT 120
  121 VSSHPNSLMK KITLLKYFRN YMSEHLLKAG ANITPREGDE LARL

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 8.7
Match: 1q4kB
Description: The polo-box domain of Plk1 in complex with a phospho-peptide
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [509-603]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PYLRTWFRTR SAIILHLSNG SVQINFFQDH TKLILCPLMA AVTYIDEKRD FRTYRLSLLE  60
   61 EYGCCKELAS RLRYARTMVD KLLSSRSASN RLKAS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 69.221849
Match: 1q4kB
Description: The polo-box domain of Plk1 in complex with a phospho-peptide
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle