YRC Public Data Repository - Protein Structure Prediction

Protein:	LETM1
Organism:	Homo sapiens
Length:	739 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for LETM1.

Description	E-value	Query Range	Subject Range
gi\|68388302 - gi\|68388302\|ref\|XP_696268.1\| PREDICTED: similar to slow myosin heavy chain 1 [Danio rerio]	8.0E-56	[133..734]	[1583..2185]
MYH4_PIG - Myosin-4 OS=Sus scrofa GN=MYH4 PE=2 SV=1	1.0E-52	[119..734]	[570..1183]
gi\|76643971 - gi\|76643971\|ref\|XP_882945.1\| PREDICTED: similar to Myosin-8 (Myosin heavy chain, skeletal muscle, pe...	3.0E-52	[119..734]	[570..1178]
gi\|73955718 - gi\|73955718\|ref\|XP_861205.1\| PREDICTED: similar to Myosin heavy chain, skeletal muscle, perinatal (M...	4.0E-52	[119..734]	[461..1072]
MYH1_HORSE - Myosin-1 OS=Equus caballus GN=MYH1 PE=2 SV=1	2.0E-51	[119..734]	[570..1184]
gi\|109491001, gi... - gi\|149052972\|gb\|EDM04789.1\| rCG34493 [Rattus norvegicus], gi\|109491001\|ref\|XP_001078064.1\| PREDICTED...	3.0E-51	[119..734]	[570..1184]
MYH8_MOUSE - Myosin-8 OS=Mus musculus GN=Myh8 PE=2 SV=2	3.0E-51	[119..734]	[570..1184]
gi\|109113271 - gi\|109113271\|ref\|XP_001113877.1\| PREDICTED: myosin, heavy polypeptide 2, skeletal muscle, adult [Mac...	4.0E-51	[119..734]	[570..1185]

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Predicted Domain #1

Region A:
Residues: [1-112]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MASILLRSCR GRAPARLPPP PRYTVPRGSP GDPAHLSCAS TLGLRNCLNV PFGCCTPIHP  60
   61 VYTSSRGDHL GCWALRPECL RIVSRAPWTS TSVGFVAVGP QCLPVRGWHS SR

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2

Region A:
Residues: [113-739]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PVRDDSVVEK SLKSLKDKNK KLEEGGPVYS PPAEVVVKKS LGQRVLDELK HYYHGFRLLW  60
   61 IDTKIAARML WRILNGHSLT RRERRQFLRI CADLFRLVPF LVFVVVPFME FLLPVAVKLF 120
  121 PNMLPSTFET QSLKEERLKK ELRVKLELAK FLQDTIEEMA LKNKAAKGSA TKDFSVFFQK 180
  181 IRETGERPSN EEIMRFSKLF EDELTLDNLT RPQLVALCKL LELQSIGTNN FLRFQLTMRL 240
  241 RSIKADDKLI AEEGVDSLNV KELQAACRAR GMRALGVTED RLRGQLKQWL DLHLHQEIPT 300
  301 SLLILSRAMY LPDTLSPADQ LKSTLQTLPE IVAKEAQVKV AEVEGEQVDN KAKLEATLQE 360
  361 EAAIQQEHRE KELQKRSEVA KDFEPERVVA APQRPGTEPQ PEMPDTVLQS ETLKDTAPVL 420
  421 EGLKEEEITK EEIDILSDAC SKLQEQKKSL TKEKEELELL KEDVQDYSED LQEIKKELSK 480
  481 TGEEKYVEES KASKRLTKRV QQMIGQIDGL ISQLEMDQQA GKLAPANGMP TGENVISVAE 540
  541 LINAMKQVKH IPESKLTSLA AALDENKDGK VNIDDLVKVI ELVDKEDVHI STSQVAEIVA 600
  601 TLEKEEKVEE KEKAKEKAEK EVAEVKS

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	44.30103
Match:	1i84S
Description:	Heavy meromyosin subfragment
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits