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View Structure Prediction Details

Protein: LYPLA1
Organism: Homo sapiens
Length: 230 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for LYPLA1.

Description E-value Query
Range		 Subject
Range
gi|109086409 - gi|109086409|ref|XP_001083287.1| PREDICTED: lysophospholipase I isoform 2 [Macaca mulatta]
 2.0E-42 [1..230] [1..230]
LYPA1_PONPY - Acyl-protein thioesterase 1 - Pongo pygmaeus (Orangutan)
LYPA1_PONAB - Acyl-protein thioesterase 1 OS=Pongo abelii GN=LYPLA1 PE=2 SV=1
 3.0E-42 [1..230] [1..230]
gi|114620143 - gi|114620143|ref|XP_519760.2| PREDICTED: hypothetical protein isoform 4 [Pan troglodytes]
 4.0E-42 [1..230] [1..230]
LYPA1_RABIT - Acyl-protein thioesterase 1 OS=Oryctolagus cuniculus GN=LYPLA1 PE=1 SV=1
LYPA1_MOUSE - Acyl-protein thioesterase 1 OS=Mus musculus GN=Lypla1 PE=1 SV=1
 6.0E-41 [1..230] [1..230]
LYPA1_BOVIN - Acyl-protein thioesterase 1 OS=Bos taurus GN=LYPLA1 PE=2 SV=1
 8.0E-41 [1..230] [1..230]
gi|49118340, gi|... - gi|49118340|gb|AAH73342.1| MGC80756 protein [Xenopus laevis], gi|148232361|ref|NP_001085785.1| MGC80...
 2.0E-40 [1..230] [1..230]
gi|50737613 - gi|50737613|ref|XP_419203.1| PREDICTED: similar to Acyl-protein thioesterase 1 (Lysophospholipase I)...
 3.0E-40 [1..230] [1..229]
gi|89266935 - gi|89266935|emb|CAJ81346.1| lysophospholipase I [Xenopus tropicalis]
 3.0E-40 [1..230] [1..230]

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Predicted Domain #1
Region A:
Residues: [1-230] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MCGNNMSTPL PAIVPAARKA TAAVIFLHGL GDTGHGWAEA FAGIRSSHIK YICPHAPVRP  60
   61 VTLNMNVAMP SWFDIIGLSP DSQEDESGIK QAAENIKALI DQEVKNGIPS NRIILGGFSQ 120
  121 GGALSLYTAL TTQQKLAGVT ALSCWLPLRA SFPQGPIGGA NRDISILQCH GDCDPLVPLM 180
  181 FGSLTVEKLK TLVNPANVTF KTYEGMMHSS CQQEMMDVKQ FIDKLLPPID

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 40.221849
Match: 1fj2A
Description: Acyl protein thioesterase 1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
hydrolase activity 2.24106351016868 bayes_pls_golite062009
catalytic activity 1.39629727416851 bayes_pls_golite062009
hydrolase activity, acting on ester bonds 1.09488027320166 bayes_pls_golite062009
lipase activity 0.849473630399459 bayes_pls_golite062009
carboxylesterase activity 0.424330502936163 bayes_pls_golite062009
palmitoyl-(protein) hydrolase activity 0.277033874372149 bayes_pls_golite062009
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle