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View Structure Prediction Details

Protein: VPS5
Organism: Saccharomyces cerevisiae
Length: 675 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for VPS5.

Description E-value Query
Range
Subject
Range
VPS5_YEAST - Vacuolar protein sorting-associated protein 5 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288...
VPS5 - Nexin-1 homolog required for localizing membrane proteins from a prevacuolar/late endosomal compartm...
0.0 [1..675] [1..675]
vps5 - retromer complex subunit Vps5
VPS5_SCHPO - Vacuolar protein sorting-associated protein vps5 OS=Schizosaccharomyces pombe (strain 972 / ATCC 248...
2.0E-69 [82..671] [4..574]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
2.0E-69 [46..675] [216..837]
SNX1_RAT - Sorting nexin-1 OS=Rattus norvegicus GN=Snx1 PE=1 SV=1
4.0E-69 [151..671] [23..515]
gi|12248793 - gi|12248793|dbj|BAB20283.1| sorting nexin 1 [Mus musculus]
7.0E-68 [151..671] [23..514]
gi|3152940 - gi|3152940|gb|AAC17182.1| sorting nexin 1 [Homo sapiens]
7.0E-67 [149..671] [21..515]

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Predicted Domain #1
Region A:
Residues: [1-198]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDYEDNLEAP VWDELNHEGD KTQSLVSNSI ESIGQISTNE ERKDNELLET TASFADKIDL  60
   61 DSAPEWKDPG LSVAGNPQLE EHDNSKADDL INSLAPEQDP IADLKNSTTQ FIATRESGGA 120
  121 LFTGNANSPL VFDDTIYDAN TSPNTSKSIS GRRSGKPRIL FDSARAQRNS KRNHSLKAKR 180
  181 TTASDDTIKT PFTDPLKK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 33.0
Match: 1bg2__
Description: Kinesin
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [199-432]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AEKENEFVEE PLDDRNERRE NNEGKFTASV EKNILEQVDR PLYNLPQTGA NISSPAEVEE  60
   61 NSEKFGKTKI GSKVPPTEKA VAFKVEVKDP VKVGELTSIH VEYTVISESS LLELKYAQVS 120
  121 RRYRDFRWLY RQLQNNHWGK VIPPPPEKQS VGSFKENFIE NRRFQMESML KKICQDPVLQ 180
  181 KDKDFLLFLT SDDFSSESKK RAFLTGSGAI NDSNDLSEVR ISEIQLLGAE DAAE

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 35.522879
Match: 1i84S_
Description: Heavy meromyosin subfragment
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [433-675]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VLKNGGIDAE SHKGFMSISF SSLPKYNEAD EFFIEKKQKI DELEDNLKKL SKSLEMVDTS  60
   61 RNTLAASTEE FSSMVETLAS LNVSEPNSEL LNNFADVHKS IKSSLERSSL QETLTMGVML 120
  121 DDYIRSLASV KAIFNQRSKL GYFLVVIEND MNKKHSQLGK LGQNIHSEKF REMRKEFQTL 180
  181 ERRYNLTKKQ WQAVGDKIKD EFQGFSTDKI REFRNGMEIS LEAAIESQKE CIELWETFYQ 240
  241 TNL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 35.522879
Match: 1i84S_
Description: Heavy meromyosin subfragment
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [345-675]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EKQSVGSFKE NFIENRRFQM ESMLKKICQD PVLQKDKDFL LFLTSDDFSS ESKKRAFLTG  60
   61 SGAINDSNDL SEVRISEIQL LGAEDAAEVL KNGGIDAESH KGFMSISFSS LPKYNEADEF 120
  121 FIEKKQKIDE LEDNLKKLSK SLEMVDTSRN TLAASTEEFS SMVETLASLN VSEPNSELLN 180
  181 NFADVHKSIK SSLERSSLQE TLTMGVMLDD YIRSLASVKA IFNQRSKLGY FLVVIENDMN 240
  241 KKHSQLGKLG QNIHSEKFRE MRKEFQTLER RYNLTKKQWQ AVGDKIKDEF QGFSTDKIRE 300
  301 FRNGMEISLE AAIESQKECI ELWETFYQTN L

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 41.0
Match: 1i84S
Description: Heavy meromyosin subfragment
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle