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View Structure Prediction Details

Protein: STE11
Organism: Saccharomyces cerevisiae
Length: 738 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for STE11.

Description E-value Query
Range
Subject
Range
STE11 - Signal transducing MEK kinase involved in pheromone response and pseudohyphal/invasive growth pathwa...
0.0 [1..738] [1..738]
gi|189491751, gi... - gi|57284082|emb|CAI43167.1| p21 protein (Cdc42/Rac)-activated kinase 3 [Homo sapiens], gi|57284006|e...
gi|157170250 - gi|157170250|gb|AAI52762.1| P21 protein (Cdc42/Rac)-activated kinase 3 [synthetic construct]
ENSPTRT00000049237 - null
0.0 [106..734] [10..520]
PAK3_RAT - Serine/threonine-protein kinase PAK 3 OS=Rattus norvegicus GN=Pak3 PE=1 SV=1
0.0 [106..734] [10..520]
gi|3420949 - gi|3420949|gb|AAC31969.1| Cdc42/Rac effector kinase; PAK-3 [Mus musculus]
0.0 [106..734] [10..520]
gi|1168176 - gi|1168176|gb|AAB35358.1| mPAK-3=p21Cdc42/Rac activated kinase [mice, fibroblast, Peptide, 543 aa]
0.0 [106..734] [10..520]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
0.0 [108..734] [18..521]

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Predicted Domain #1
Region A:
Residues: [1-136]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MHKERPLNKA SMIRSPVDEI YMEQTQTAEG TDLLIGDEKT NDLPFVQLFL EEIGCTQYLD  60
   61 SFIQCNLVTE EEIKYLDKDI LIALGVNKIG DRLKILRKSK SFQRDKRIEQ VNRLKNLMEK 120
  121 VSSLSTATLS MNSELI

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 9.89
Match: 1b0xA
Description: EphA4 receptor tyrosine kinases
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [137-232]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PEKHCVIFIL NDGSAKKVNV NGCFNADSIK KRLIRRLPHE LLATNSNGEV TKMVQDYDVF  60
   61 VLDYTKNVLH LLYDVELVTI CHANDRVEKN RLIFVS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 13.69897
Match: 1f3mA_
Description: pak1 autoregulatory domain
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [233-369]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KDQTPSDKAI STSKKLYLRT LSALSQVGPS SSNLLAQNKG ISHNNAEGKL RIDNTEKDRI  60
   61 RQIFNQRPPS EFISTNLAGY FPHTDMKRLQ KTMRESFRHS ARLSIAQRRP LSAESNNIGD 120
  121 ILLKHSNAVD MALLQGL

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [370-556]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DQTRLSSKLD TTKIPKLAHK RPEDNDAISN QLELLSVESG EEEDHDFFGE DSDIVSLPTK  60
   61 IATPKNWLKG ACIGSGSFGS VYLGMNAHTG ELMAVKQVEI KNNNIGVPTD NNKQANSDEN 120
  121 NEQEEQQEKI EDVGAVSHPK TNQNIHRKMV DALQHEMNLL KELHHENIVT YYGASQEGGN 180
  181 LNIFLEY

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 480.457575
Match: 1f3mC_
Description: pak1
Matching Structure (courtesy of the PDB):

Predicted Domain #5
Region A:
Residues: [557-738]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VPGGSVSSML NNYGPFEESL ITNFTRQILI GVAYLHKKNI IHRDIKGANI LIDIKGCVKI  60
   61 TDFGISKKLS PLNKKQNKRA SLQGSVFWMS PEVVKQTATT AKADIWSTGC VVIEMFTGKH 120
  121 PFPDFSQMQA IFKIGTNTTP EIPSWATSEG KNFLRKAFEL DYQYRPSALE LLQHPWLDAH 180
  181 II

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 480.457575
Match: 1f3mC_
Description: pak1
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle