YRC Public Data Repository - Protein Structure Prediction

Protein:	PRP18
Organism:	Saccharomyces cerevisiae
Length:	251 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PRP18.

Description	E-value	Query Range	Subject Range
PRP18_YEAST - Pre-mRNA-splicing factor 18 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=PRP18 PE=1 S... PRP18 - Splicing factor involved in the positioning of the 3' splice site during the second catalytic step o... gi\|151943293 - gi\|151943293\|gb\|EDN61606.1\| RNA splicing factor [Saccharomyces cerevisiae YJM789]	3.0E-94	[1..251]	[1..251]
gi\|46441380, gi\|... - gi\|68472986\|ref\|XP_719558.1\| hypothetical protein CaO19.2112 [Candida albicans SC5314], gi\|68472729\|... gi\|238881834 - gi\|238881834\|gb\|EEQ45472.1\| hypothetical protein CAWG_03800 [Candida albicans WO-1] orf19.9660, orf1... - orf19.2112 CGDID:CAL0005277 Assembly 19, Contig19-10139 (209044, 208232) CDS, reverse complemented, ...	4.0E-69	[3..246]	[1..267]
gi\|15221867, gi\|... - gi\|3776560\|gb\|AAC64877.1\| Similar to gb\|U51990 hPrp18 (splicing factor) gene from Homo sapiens. [Ara...	1.0E-56	[59..245]	[1..207]
PRP18_RAT - Pre-mRNA-splicing factor 18 OS=Rattus norvegicus GN=Prpf18 PE=2 SV=1	1.0E-54	[51..246]	[146..332]
PRP18_MOUSE - Pre-mRNA-splicing factor 18 OS=Mus musculus GN=Prpf18 PE=1 SV=1	1.0E-54	[51..246]	[146..332]
gi\|114629422, gi... - gi\|114629424\|ref\|XP_001142558.1\| PREDICTED: PRP18 pre-mRNA processing factor 18 homolog isoform 6 [P... PRPF18 - PRP18 pre-mRNA processing factor 18 homolog (S. cerevisiae) gi\|109088233 - gi\|109088233\|ref\|XP_001086905.1\| PREDICTED: PRP18 pre-mRNA processing factor 18 homolog isoform 5 [M...	2.0E-54	[51..246]	[146..332]
gi\|42544920, gi\|... - gi\|46111303\|ref\|XP_382709.1\| hypothetical protein FG02533.1 [Gibberella zeae PH-1], gi\|42544920\|gb\|E...	1.0E-49	[67..246]	[167..341]

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Predicted Domain #1

Region A:
Residues: [1-251]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDLDLASILK GEISKKKKEL ANSKGVQPPC TEKFQPHESA NIDETPRQVE QESTDEENLS  60
   61 DNQSDDIRTT ISKLENRPER IQEAIAQDKT ISVIIDPSQI GSTEGKPLLS MKCNLYIHEI 120
  121 LSRWKASLEA YHPELFLDTK KALFPLLLQL RRNQLAPDLL ISLATVLYHL QQPKEINLAV 180
  181 QSYMKLSIGN VAWPIGVTSV GIHARSAHSK IQGGRNAANI MIDERTRLWI TSIKRLITFE 240
  241 EWYTSNHDSL A

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	63.39794
Match:	1dvkA_
Description:	Functional domain of the splicing factor Prp18
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
	8.4933513491836	bayes_pls_golite062009
second spliceosomal transesterification activity	6.08743179391779	bayes_pls_golite062009
catalytic activity	0.60409960326459	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: