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View Structure Prediction Details

Protein: DPB2
Organism: Saccharomyces cerevisiae
Length: 689 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for DPB2.

Description E-value Query
Range
Subject
Range
DPB2 - Second largest subunit of DNA polymerase II (DNA polymerase epsilon), required for normal yeast chro...
0.0 [1..689] [4..692]
DPB2_ASHGO - DNA polymerase epsilon subunit B OS=Ashbya gossypii GN=DPB2 PE=3 SV=1
DPB2_ASHGO - DNA polymerase epsilon subunit B OS=Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NR...
0.0 [5..689] [4..677]
gi|40742829, gi|... - gi|67900904|ref|XP_680708.1| hypothetical protein AN7439.2 [Aspergillus nidulans FGSC A4], ref|XP_41...
0.0 [6..673] [33..725]
gi|28950027 - gi|28950027|emb|CAD70782.1| related to DNA directed DNA polymerase II chain B [Neurospora crassa]
0.0 [7..675] [75..831]
gi|42547282, gi|... - gi|46136767|ref|XP_390075.1| hypothetical protein FG09899.1 [Gibberella zeae PH-1], gi|42547282|gb|E...
0.0 [7..682] [48..769]
orf19.7564 - DPB2 CGDID:CAL0000130 Assembly 19, Contig19-2518 (46094, 43968) CDS, reverse complemented, translate...
gi|46441139, gi|... - gi|68473041|ref|XP_719326.1| potential DNA polymerase epsilon subunit [Candida albicans SC5314], gi|...
0.0 [8..688] [6..707]
POLE2 - polymerase (DNA directed), epsilon 2 (p59 subunit)
0.0 [89..687] [4..524]

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Predicted Domain #1
Region A:
Residues: [1-235]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MFGSGNVLPV KIQPPLLRPL AYRVLSRKYG LSIKSDGLSA LAEFVGTNIG ANWRQGPATI  60
   61 KFLEQFAAVW KQQERGLFID QSGVKEVIQE MKEREKVEWS HEHPIQHEEN ILGRTDDDEN 120
  121 NSDDEMPIAA DSSLQNVSLS SPMRQPTERD EYKQPFKPES SKALDWRDYF KVINASQQQR 180
  181 FSYNPHKMQF IFVPNKKQNG LGGIAGFLPD IEDKVQMFLT RYYLTNDRVM RNENF

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [236-361]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QNSDMFNPLS SMVSLQNELS NTNRQQQSSS MSITPIKNLL GRDAQNFLLL GLLNKNFKGN  60
   61 WSLEDPSGSV EIDISQTIPT QGHYYVPGCM VLVEGIYYSV GNKFHVTSMT LPPGERREIT 120
  121 LETIGN

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [362-587]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LDLLGIHGIS NNNFIARLDK DLKIRLHLLE KELTDHKFVI LGANLFLDDL KIMTALSKIL  60
   61 QKLNDDPPTL LIWQGSFTSV PVFASMSSRN ISSSTQFKNN FDALATLLSR FDNLTENTTM 120
  121 IFIPGPNDLW GSMVSLGASG TLPQDPIPSA FTKKINKVCK NVVWSSNPTR IAYLSQEIVI 180
  181 FRDDLSGRFK RHRLEFPFNE SEDVYTENDN MMSKDTDIVP IDELVK

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted functions:

Term Confidence Notes
transferase activity, transferring phosphorus-containing groups 3.253873361615 bayes_pls_golite062009
transferase activity 2.86536343515876 bayes_pls_golite062009
protein serine/threonine phosphatase activity 2.60559887605086 bayes_pls_golite062009
phosphatase activity 2.32143054924462 bayes_pls_golite062009
phosphoric ester hydrolase activity 2.29895042460743 bayes_pls_golite062009
phosphoprotein phosphatase activity 2.25451947416972 bayes_pls_golite062009
hydrolase activity, acting on ester bonds 1.69489536786659 bayes_pls_golite062009
binding 1.50157839850353 bayes_pls_golite062009
catalytic activity 1.30037658165549 bayes_pls_golite062009
structural molecule activity 0.371786873304259 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 0.33393888611713 bayes_pls_golite062009
kinase activity 0.308698487135154 bayes_pls_golite062009
protein binding 0.30363127120976 bayes_pls_golite062009
protein kinase activity 0.108241336192419 bayes_pls_golite062009
hydrolase activity 0.070797330694107 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [588-689]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EPDQLPQKVQ ETRKLVKTIL DQGHLSPFLD SLRPISWDLD HTLTLCPIPS TMVLCDTTSA  60
   61 QFDLTYNGCK VINPGSFIHN RRARYMEYVP SSKKTIQEEI YI

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle