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View Structure Prediction Details

Protein: MSC2
Organism: Saccharomyces cerevisiae
Length: 724 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for MSC2.

Description E-value Query
Range
Subject
Range
MSC2 - Member of the cation diffusion facilitator family, localizes to the endoplasmic reticulum and nucleu...
MSC2_YEAST - Probable zinc transporter MSC2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=MSC2 PE=1...
0.0 [1..724] [1..724]
gi|45200995, gi|... - gi|45200995|ref|NP_986565.1| AGL102Wp [Ashbya gossypii ATCC 10895], gi|44985765|gb|AAS54389.1| AGL10...
gi|44985765 - gi|44985765|gb|AAS54389.1| AGL102Wp [Ashbya gossypii ATCC 10895]
0.0 [1..719] [2..690]
CE32233 - status:Partially_confirmed UniProt:Q8WQB6 protein_id:CAD21657.2
2.0E-87 [20..664] [1..696]
gi|39580740, gi|... - gi|39580740|emb|CAE64126.1| Hypothetical protein CBG08742 [Caenorhabditis briggsae], gi|187032406|em...
gi|157748505 - gi|157748505|ref|XP_001669347.1| Hypothetical protein CBG08742 [Caenorhabditis briggsae AF16]
4.0E-87 [51..664] [41..690]
ZNT5_MOUSE - Zinc transporter 5 OS=Mus musculus GN=Slc30a5 PE=1 SV=1
3.0E-78 [87..696] [93..725]
gi|68481192, gi|... - gi|68481333|ref|XP_715441.1| likely cation efflux pump [Candida albicans SC5314], gi|68481192|ref|XP...
orf19.10644, orf... - orf19.3132 CGDID:CAL0002286 Assembly 19, Contig19-10166 (93673, 91793) CDS, reverse complemented, tr...
3.0E-76 [98..703] [8..625]
gi|22325475 - gi|22325475|ref|NP_178539.2| cation efflux family protein [Arabidopsis thaliana]
8.0E-74 [28..506] [39..537]
SLC30A5 - solute carrier family 30 (zinc transporter), member 5
HGNC:19089|MIM:6... - carrier family 30 (zinc transporter), member 5
gi|157169762, gi... - gi|190689809|gb|ACE86679.1| solute carrier family 30 (zinc transporter), member 5 protein [synthetic...
8.0E-74 [87..696] [95..729]

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Predicted Domain #1
Region A:
Residues: [1-282]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNLQELLAKV PLLLSYPTII LSSNLIVPSH NDLISRAAST SAAEYADEKL IFFSTDHAIR  60
   61 LIFLPTFVAS SFNLFAHYFN FINYSSRRKY YVLFTAIYFL SILTAIFHPI QSTCITLLII 120
  121 KLLTTADESS PKIALNFKTI LKTFVPFITL TLVILRWDPS FDASSGDVNK ISTSLAAYAL 180
  181 LILTLRYASP LILSTLSSSI GVVSKDTSVA QHSISRNKRF PLILVLPIFS FVLLYLMTIV 240
  241 NKTYNIQLLM VFVFFGCLSI FFLSLKDLFT EDGNQKKGGQ ED

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [283-372]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EYCRMFDIKY MISYLWLTRF TILLTGIMAI VVHFLSFNEI TSSIKTDLLS LLFVVVAEYV  60
   61 SSFSNKQPDS HSHNHAHHHS HLTDSLPLEN 

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.846 a.4.9 Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3

Predicted Domain #3
Region A:
Residues: [373-502]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ESMFKQMALN KDTRSIFSFL LLNTAFMFVQ LLYSFRSKSL GLLSDSLHMA LDCTSLLLGL  60
   61 IAGVLTKKPA SDKFPFGLNY LGTLAGFTNG VLLLGIVCGI FVEAIERIFN PIHLHATNEL 120
  121 LVVATLGLLV 

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted functions:

Term Confidence Notes
transporter activity 4.27173462293249 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [503-724]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NLVGLFAFDH GAHDHGGTDN ENMKGIFLHI LADTLGSVGV VISTLLIKLT HWPIFDPIAS  60
   61 LLIGSLILLS ALPLLKSTSA NILLRLDDKK HNLVKSALNQ ISTTPGITGY TTPRFWPTES 120
  121 GSSGHSHAHT HSHAENHSHE HHHDQKNGSQ EHPSLVGYIH VQYVDGENST IIKKRVEKIF 180
  181 ENVSIKAWVQ VEPQNSTCWC RATSMNTISA NPNSLPLQPI AN

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle